Animal models in epilepsy research: legacies and new directions

On the nature of seizure dynamics

(2014) Viktor K. Jirsa et al.   BRAIN

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

The hidden genetics of epilepsy—a clinically important new paradigm

(2014) Rhys H. Thomas et al.   Nature Reviews Neurology

Forecasting Seizures in Dogs with Naturally Occurring Epilepsy

(2014) J. Jeffry Howbert et al.   PLoS One

Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury

(2014) Akira Sakurai et al.   eLife

De Novo Loss-of-Function Mutations in CHD2 Cause a Fever-Sensitive Myoclonic Epileptic Encephalopathy Sharing Features with Dravet Syndrome

(2013) Arvid Suls et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Canine epilepsy as a translational model?

(2013) Heidrun Potschka et al.   EPILEPSIA

Hippocampal neuropathology of domoic acid-induced epilepsy in California sea lions (Zalophus californianus)

(2013) Paul S. Buckmaster et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Two-photon imaging of neural population activity in zebrafish

(2013) Sabine L. Renninger et al.   METHODS

Modeling Alzheimer’s disease in transgenic rats

(2013) Sonia Do Carmo et al.   Molecular Neurodegeneration

A systematic genome-wide analysis of zebrafish protein-coding gene function

(2013) Ross N. W. Kettleborough et al.   NATURE

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Epileptic baboons have lower numbers of neurons in specific areas of cortex

(2013) N. A. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrating anatomy and function for zebrafish circuit analysis

(2013) Aristides B. Arrenberg et al.   Frontiers in Neural Circuits

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment

(2013) Scott C. Baraban et al.   Nature Communications

A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors

(2012) Robert F. Hunt et al.   EXPERIMENTAL NEUROLOGY

A rat model for LGI1-related epilepsies

(2012) Stéphanie Baulac et al.   HUMAN MOLECULAR GENETICS

Painted Turtle Cortex is Resistant to an in Vitro Mimic of the Ischemic Mammalian Penumbra

(2012) Matthew Edward Pamenter et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Knock-In Model of Human Epilepsy in Drosophila Reveals a Novel Cellular Mechanism Associated with Heat-Induced Seizure

(2012) L. Sun et al.   JOURNAL OF NEUROSCIENCE

Post-Translational Oxidative Modification and Inactivation of Mitochondrial Complex I in Epileptogenesis

(2012) K. Ryan et al.   JOURNAL OF NEUROSCIENCE

Autistic-like behaviour in Scn1a +/− mice and rescue by enhanced GABA-mediated neurotransmission

(2012) Sung Han et al.   NATURE

Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy

(2012) Raymund Y.K. Pun et al.   NEURON

On the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools

(2012) V. Duranthon et al.   TRANSGENIC RESEARCH

Aberrant expression of genes necessary for neuronal development and notch signaling in an epileptic mind bomb zebrafish

(2011) Gabriela A. Hortopan et al.   DEVELOPMENTAL DYNAMICS

Expression and function of KCNQ channels in larval zebrafish

(2011) Sally W. Chege et al.   Developmental Neurobiology

The relevance of individual genetic background and its role in animal models of epilepsy

(2011) P. Elyse Schauwecker   EPILEPSY RESEARCH

Impaired neural development in a zebrafish model for Lowe syndrome

(2011) Irene Barinaga-Rementeria Ramirez et al.   HUMAN MOLECULAR GENETICS

A neuroprotective role for polyamines in a Xenopus tadpole model of epilepsy

(2011) Mark R Bell et al.   NATURE NEUROSCIENCE

Action potentials drive body wall muscle contractions in Caenorhabditis elegans

(2011) S. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs

(2011) Wolfgang Löscher   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Knockdown of zebrafish Lgi1a results in abnormal development, brain defects and a seizure-like behavioral phenotype

(2010) Y. Teng et al.   HUMAN MOLECULAR GENETICS

Introducing Songbirds as a Model System for Epilepsy Research

(2010) Daniel Margoliash et al.   JOURNAL OF CLINICAL NEUROPHYSIOLOGY

Spontaneous Seizures and Altered Gene Expression in GABA Signaling Pathways in a mind bomb Mutant Zebrafish

(2010) G. A. Hortopan et al.   JOURNAL OF NEUROSCIENCE

Adult-Born Hippocampal Neurons Are More Numerous, Faster Maturing, and More Involved in Behavior in Rats than in Mice

(2009) J. S. Snyder et al.   JOURNAL OF NEUROSCIENCE

A Primer for Morpholino Use in Zebrafish

(2009) Brent R. Bill et al.   Zebrafish

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex

(2008) Ling-Hui Zeng et al.   ANNALS OF NEUROLOGY

A catalog of SCN1A variants

(2008) Christoph Lossin   BRAIN & DEVELOPMENT