HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease

Neuroinflammation in Alzheimer's Disease: Mechanisms, Pathologic Consequences, and Potential for Therapeutic Manipulation

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Anti-high mobility group box 1 antibody exerts neuroprotection in a rat model of Parkinson's disease

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Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease

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Altered Nrf2 Signaling Mediates Hypoglycemia-Induced Blood–Brain Barrier Endothelial Dysfunction In Vitro

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The neurovascular unit - concept review

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Role of high-mobility group box-1 protein in disruption of vascular barriers and regulation of leukocyte–endothelial interactions

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Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

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Pericyte loss influences Alzheimer-like neurodegeneration in mice

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HMGB1 in vascular diseases: Its role in vascular inflammation and atherosclerosis

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Does a Pro-Inflammatory Process Precede Alzheimers Disease and Mild Cognitive Impairment?

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HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

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Soluble thrombomodulin levels in plasma of multiple sclerosis patients and their implication

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HMGB1 in Development and Diseases of the Central Nervous System

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A breach in the blood–brain barrier

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Brain and Circulating Levels of Aβ1–40 Differentially Contribute to Vasomotor Dysfunction in the Mouse Brain

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The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

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High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products

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TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

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(2011) Edward M. Conway   Seminars in Immunopathology

Anti-high Mobility Group Box-1 Monoclonal Antibody Protects the Blood–Brain Barrier From Ischemia-Induced Disruption in Rats

(2011) Jiyong Zhang et al.   STROKE

Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy

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Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

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Potential biomarkers for vascular damage in ALzheimer’s disease: Thrombomodulin and von Willebrand factor

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HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption

(2010) Rachel K. Wolfson et al.   MICROVASCULAR RESEARCH

Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy

(2009) Justin Zaghi et al.   ACTA NEUROPATHOLOGICA

Coagulation and innate immune responses: can we view them separately?

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Plasma thrombomodulin activity, tissue factor activity and high levels of circulating procoagulant phospholipid as prognostic factors for acute myocardial infarction

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Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

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Soluble Forms of RAGE in Human Diseases: Clinical and Therapeutical Implications

(2009) Francesca Santilli et al.   CURRENT MEDICINAL CHEMISTRY

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(2009) Joe G.N. Garcia   MICROVASCULAR RESEARCH

Does neuroinflammation fan the flame in neurodegenerative diseases?

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Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)

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