Inducible Pluripotent Stem Cell-Derived Small Extracellular Vesicles Rejuvenate Senescent Blood–Brain Barrier to Protect against Ischemic Stroke in Aged Mice

Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke

(2021) Zhongfei Zhang et al.   Aging-US

miR-31 from adipose stem cell-derived extracellular vesicles promotes recovery of neurological function after ischemic stroke by inhibiting TRAF6 and IRF5

(2021) Hui Lv et al.   EXPERIMENTAL NEUROLOGY

Embryonic Stem Cell Derived Small Extracellular Vesicles Modulate Regulatory T Cells to Protect against Ischemic Stroke

(2021) Yuguo Xia et al.   ACS Nano

Circulating Pro-Inflammatory Exosomes Worsen Stroke Outcomes in Aging

(2021) Hongxia Zhang et al.   CIRCULATION RESEARCH

Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?

(2021) Yan-mei Qiu et al.   Frontiers in Immunology

Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway

(2021) Lin Zhang et al.   Cell Death & Disease

Implicating endothelial cell senescence to dysfunction in the ageing and diseased brain

(2020) Sara I. Graves et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Endothelium-targeted overexpression of Krüppel-like factor 11 protects the blood-brain barrier function after ischemic brain injury

(2020) Xuejing Zhang et al.   BRAIN PATHOLOGY

Extracellular Vesicles Derived from Neural Progenitor Cells––a Preclinical Evaluation for Stroke Treatment in Mice

(2020) X. Zheng et al.   Translational Stroke Research

ESC‐sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia

(2020) Guowen Hu et al.   Advanced Science

Physiological blood–brain transport is impaired with age by a shift in transcytosis

(2020) Andrew C. Yang et al.   NATURE

Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke

(2020) Yuguo Xia et al.   Stem Cell Research & Therapy

Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke

(2020) Abolfazl Rahmani et al.   AGEING RESEARCH REVIEWS

ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the MYT1-Egln3-Sirt1 Axis

(2020) Guowen Hu et al.   MOLECULAR THERAPY

Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging

(2020) Nicholas E. Propson et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys

(2020) Veronica Go et al.   EXPERIMENTAL NEUROLOGY

Highly Purified Human Extracellular Vesicles Produced by Stem Cells Alleviate Aging Cellular Phenotypes of Senescent Human Cells

(2019) Senquan Liu et al.   STEM CELLS

Human embryonic stem cell-derived exosomes promote pressure ulcer healing in aged mice by rejuvenating senescent endothelial cells

(2019) Bi Chen et al.   Stem Cell Research & Therapy

The effect of aging on brain injury and recovery after stroke

(2019) Selva Baltan et al.   NEUROBIOLOGY OF DISEASE

Human bone marrow mesenchymal stem cell-derived extracellular vesicles attenuate neuroinflammation evoked by focal brain injury in rats

(2019) Sylwia Dabrowska et al.   Journal of Neuroinflammation

Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization

(2018) Mei Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Exosomes Derived from Human Induced Pluripotent Stem Cells Ameliorate the Aging of Skin Fibroblasts

(2018) Myeongsik Oh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Post-stroke administration of omega-3 polyunsaturated fatty acids promotes neurovascular restoration after ischemic stroke in mice: Efficacy declines with aging

(2018) Xiaoyan Jiang et al.   NEUROBIOLOGY OF DISEASE

Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging

(2018) Svetlana M. Stamatovic et al.   NEUROBIOLOGY OF DISEASE

Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM

(2018) Min Hee Park et al.   NEURON

In Vivo Expansion of Regulatory T Cells with IL-2/IL-2 Antibody Complex Protects against Transient Ischemic Stroke

(2018) Haiyue Zhang et al.   JOURNAL OF NEUROSCIENCE

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

The effect of age, sex and strains on the performance and outcome in animal models of stroke

(2018) Hongxia Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood–brain barrier disruption after ischemic brain injury

(2017) Yejie Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway

(2017) Ouyang Chen et al.   Scientific Reports

Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model

(2017) Robin L. Webb et al.   Translational Stroke Research

Sirtuins, Cell Senescence, and Vascular Aging

(2016) Yujiro Kida et al.   CANADIAN JOURNAL OF CARDIOLOGY

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

(2016) Yu Yamazaki et al.   STROKE

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

(2016) Yejie Shi et al.   Nature Communications

Sub-acute systemic erythropoietin administration reduces ischemic brain injury in an age-dependent manner

(2016) Peter Thériault et al.   Oncotarget

Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals

(2016) Yejie Shi et al.   Translational Stroke Research

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

The Redox-sensitive Induction of the Local Angiotensin System Promotes Both Premature and Replicative Endothelial Senescence: Preventive Effect of a StandardizedCrataegusExtract

(2015) Sonia Khemais-Benkhiat et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

SIRT1Overexpression Maintains Cell Phenotype and Function of Endothelial Cells Derived from Induced Pluripotent Stem Cells

(2015) Bin Jiang et al.   STEM CELLS AND DEVELOPMENT

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

(2015) Thorsten R. Doeppner et al.   Stem Cells Translational Medicine

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

(2014) M. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging aggravates ischemic stroke-induced brain damage in mice with chronic peripheral infection

(2013) Hiramani Dhungana et al.   AGING CELL

Thrombin-Induced Cerebral Hemorrhage: Role of Protease-Activated Receptor-1

(2013) Yingying Cheng et al.   Translational Stroke Research

eNOS activation and NO function: Structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity

(2011) Ruslan Rafikov et al.   JOURNAL OF ENDOCRINOLOGY

SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans

(2011) Anthony J. Donato et al.   JOURNAL OF PHYSIOLOGY-LONDON

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

(2008) Q.-j. Zhang et al.   CARDIOVASCULAR RESEARCH