Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

(2016) Yejie Shi et al.   Nature Communications

Intercellular cross-talk in intracerebral hemorrhage

(2015) Yusuke Egashira et al.   BRAIN RESEARCH

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke

(2015) Michael Gliem et al.   GLIA

Ultrastructural analysis of blood–brain barrier breakdown in the peri-infarct zone in young adult and aged mice

(2015) Patrick C Nahirney et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Attenuation of acute stroke injury in rat brain by minocycline promotes blood–brain barrier remodeling and alternative microglia/macrophage activation during recovery

(2015) Yirong Yang et al.   Journal of Neuroinflammation

Brain Vascular Pericytes Following Ischemia Have Multipotential Stem Cell Activity to Differentiate Into Neural and Vascular Lineage Cells

(2015) Takayuki Nakagomi et al.   STEM CELLS

2015 American Heart Association/American Stroke Association Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment

(2015) William J. Powers et al.   STROKE

Stroke Neurologist’s Perspective on the New Endovascular Trials

(2015) James C. Grotta et al.   STROKE

Critical Early Thrombolytic and Endovascular Reperfusion Therapy for Acute Ischemic Stroke Victims: a Call for Adjunct Neuroprotection

(2015) Paul A. Lapchak   Translational Stroke Research

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

The impact of microglial activation on blood-brain barrier in brain diseases

(2014) Anna Carolina Carvalho da Fonseca et al.   Frontiers in Cellular Neuroscience

Effect of Simvastatin on MMPs and TIMPs in Human Brain Endothelial Cells and Experimental Stroke

(2014) Björn Reuter et al.   Translational Stroke Research

Recombinant T Cell Receptor Ligand Treatment Improves Neurological Outcome in the Presence of Tissue Plasminogen Activator in Experimental Ischemic Stroke

(2014) Wenbin Zhu et al.   Translational Stroke Research

Evaluation of the Protective Potential of Brain Microvascular Endothelial Cell Autophagy on Blood–Brain Barrier Integrity During Experimental Cerebral Ischemia–Reperfusion Injury

(2014) Haiying Li et al.   Translational Stroke Research

Remote Ischemic Perconditioning is Effective After Embolic Stroke in Ovariectomized Female Mice

(2014) Md Nasrul Hoda et al.   Translational Stroke Research

Effect of Clot Aging and Cholesterol Content on Ultrasound-Assisted Thrombolysis

(2014) Yufeng Zhou et al.   Translational Stroke Research

Hyperglycemia, Acute Ischemic Stroke, and Thrombolytic Therapy

(2014) Sherif Hafez et al.   Translational Stroke Research

Longitudinal Assessment of Imatinib’s Effect on the Blood–Brain Barrier After Ischemia/Reperfusion Injury with Permeability MRI

(2014) Zamir Merali et al.   Translational Stroke Research

Blood-Brain Barrier Breakdown after Embolic Stroke in Rats Occurs without Ultrastructural Evidence for Disrupting Tight Junctions

(2013) Martin Krueger et al.   PLoS One

Thrombin-Induced Cerebral Hemorrhage: Role of Protease-Activated Receptor-1

(2013) Yingying Cheng et al.   Translational Stroke Research

Disruption of Ion Homeostasis in the Neurogliovascular Unit Underlies the Pathogenesis of Ischemic Cerebral Edema

(2013) Arjun Khanna et al.   Translational Stroke Research

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage

(2012) J. Liu et al.   JOURNAL OF NEUROSCIENCE

The vascular neural network—a new paradigm in stroke pathophysiology

(2012) John H. Zhang et al.   Nature Reviews Neurology

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE