Circulating Pro-Inflammatory Exosomes Worsen Stroke Outcomes in Aging

Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer’s disease

(2019) Lynn Pulliam et al.   JOURNAL OF NEUROVIROLOGY

Higher exosomal tau, amyloid-beta 42 and IL-10 are associated with mild TBIs and chronic symptoms in military personnel

(2018) Jessica Gill et al.   BRAIN INJURY

The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

(2018) Junichi Matsumoto et al.   CURRENT PHARMACEUTICAL DESIGN

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

(2018) Guo-Hong Cui et al.   FASEB JOURNAL

Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice

(2018) Ali Alawieh et al.   Science Translational Medicine

Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease

(2018) Mengke Qu et al.   JOURNAL OF CONTROLLED RELEASE

Microglial repopulation resolves inflammation and promotes brain recovery after injury

(2017) Rachel A. Rice et al.   GLIA

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs

(2017) Yalin Zhang et al.   NATURE

MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

(2017) Hongqi Xin et al.   STROKE

miRNA in Circulating Microvesicles as Biomarkers for Age-Related Cognitive Decline

(2017) Asha Rani et al.   Frontiers in Aging Neuroscience

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

Optimising Golgi–Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease

(2016) Zubeyde Bayram-Weston et al.   JOURNAL OF NEUROSCIENCE METHODS

Complement, a target for therapy in inflammatory and degenerative diseases

(2015) B. Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems

(2015) Ari Waisman et al.   TRENDS IN IMMUNOLOGY

Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation

(2015) Monica R. P. Elmore et al.   PLoS One

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Rapid Golgi Analysis Method for Efficient and Unbiased Classification of Dendritic Spines

(2014) W. Christopher Risher et al.   PLoS One

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination

(2013) Aya D. Pusic et al.   GLIA

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model

(2013) Wenjun Li et al.   NEUROBIOLOGY OF DISEASE

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

MicroRNAs in body fluids—the mix of hormones and biomarkers

(2011) Maria Angelica Cortez et al.   Nature Reviews Clinical Oncology

MicroRNAs in cardiac disease

(2011) Gerald W. Dorn   Translational Research

Ischemic stroke in the elderly: an overview of evidence

(2010) Ruo-Li Chen et al.   Nature Reviews Neurology

Targeting the Ischemic Penumbra

(2010) P. Ramos-Cabrer et al.   STROKE

Involvement of Notch1 Signaling in Neurogenesis in the Subventricular Zone of Normal and Ischemic Rat Brain in Vivo

(2009) XiaoMei Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Changes in Experimental Stroke Outcome across the Life Span

(2009) Fudong Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

(2009) Marc Fisher et al.   STROKE