Structure-Guided Design of a Potent and Specific Inhibitor against the Genomic Mutator APOBEC3A

The Base-Editing Enzyme APOBEC3A Catalyzes Cytosine Deamination in RNA with Low Proficiency and High Selectivity

(2022) Aleksia Barka et al.   ACS Chemical Biology

Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination

(2022) Riccardo Pecori et al.   NATURE REVIEWS GENETICS

An extended APOBEC3A mutation signature in cancer

(2021) Adam Langenbucher et al.   Nature Communications

The current landscape of nucleic acid therapeutics

(2021) Jayesh A. Kulkarni et al.   Nature Nanotechnology

Photoactivatable Circular Caged Oligonucleotides for Transcriptome In Vivo Analysis (TIVA)

(2021) Linlin Yang et al.   ChemPhotoChem

Controllable genome editing with split-engineered base editors

(2021) Kiara N. Berríos et al.   Nature Chemical Biology

Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2

(2020) Salvatore Di Giorgio et al.   Science Advances

Oligonucleotide Probe for Transcriptome in Vivo Analysis (TIVA) of Single Neurons with Minimal Background

(2020) Sean B. Yeldell et al.   ACS Chemical Biology

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

(2020) Emily K. Law et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcription factor binding affinities and DNA shape readout

(2020) Max Schnepf et al.   iScience

Structure, stability and specificity of the binding of ssDNA and ssRNA with proteins

(2019) Arumay Pal et al.   PLoS Computational Biology

Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features

(2019) Rémi Buisson et al.   SCIENCE

APOBEC3A Loop 1 Is a Determinant for Single-Stranded DNA Binding and Deamination

(2019) Samantha J. Ziegler et al.   BIOCHEMISTRY

Differential Inhibition of APOBEC3 DNA‐Mutator Isozymes by Fluoro‐ and Non‐Fluoro‐Substituted 2′‐Deoxyzebularine Embedded in Single‐Stranded DNA

(2019) Maksim V. Kvach et al.   CHEMBIOCHEM

Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure

(2019) Yumeng Z McDaniel et al.   NUCLEIC ACIDS RESEARCH

APOBEC3A is a prominent cytidine deaminase in breast cancer

(2019) Luis M. Cortez et al.   PLoS Genetics

Efficient Synthesis of Light-Triggered Circular Antisense Oligonucleotides Targeting Cellular Protein Expression

(2018) Linlin Yang et al.   CHEMBIOCHEM

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

(2018) Tania V. Silvas et al.   Scientific Reports

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues

(2018) Maksim V. Kvach et al.   BIOCHEMISTRY

AID Recognizes Structured DNA for Class Switch Recombination

(2017) Qi Qiao et al.   MOLECULAR CELL

APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA

(2017) Emily K. Schutsky et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

(2017) Takahide Kouno et al.   Nature Communications

Stem-loop structure preference for site-specific RNA editing by APOBEC3A and APOBEC3G

(2017) Shraddha Sharma et al.   PeerJ

APOBEC3A damages the cellular genome during DNA replication

(2016) Abby M. Green et al.   CELL CYCLE

Advanced Design of Dumbbell-shaped Genetic Minimal Vectors Improves Non-coding and Coding RNA Expression

(2016) Xiaoou Jiang et al.   MOLECULAR THERAPY

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

(2016) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

(2016) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study

(2016) Shumei Yan et al.   Journal of Cancer

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

(2015) Kin Chan et al.   NATURE GENETICS

APOBECs and virus restriction

(2015) Reuben S. Harris et al.   VIROLOGY

APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma

(2015) Brian A. Walker et al.   Nature Communications

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

Structural determinants of human APOBEC3A enzymatic and nucleic acid binding properties

(2013) M. Mitra et al.   NUCLEIC ACIDS RESEARCH

Structural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3F

(2013) Karen K. Siu et al.   Nature Communications

NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity

(2013) In-Ja L. Byeon et al.   Nature Communications

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

(2013) Benjamin JM Taylor et al.   eLife

AID/APOBEC cytosine deaminase induces genome-wide kataegis

(2012) Artem G Lada et al.   Biology Direct

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Small-Molecule APOBEC3G DNA Cytosine Deaminase Inhibitors Based on a 4-Amino-1,2,4-triazole-3-thiol Scaffold

(2012) Margaret E. Olson et al.   ChemMedChem

First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G

(2011) Ming Li et al.   ACS Chemical Biology

Origins of Specificity in Protein-DNA Recognition

(2010) Remo Rohs et al.   Annual Review of Biochemistry

Human APOBEC3G-Mediated Editing Can Promote HIV-1 Sequence Diversification and Accelerate Adaptation to Selective Pressure

(2010) E.-Y. Kim et al.   JOURNAL OF VIROLOGY

Synthesis of DNA Dumbbell Based Inhibitors for the Human DNA Methyltransferase Dnmt1

(2008) David Kuch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins

(2008) R. S. LaRue et al.   JOURNAL OF VIROLOGY