Efficient Synthesis of Light-Triggered Circular Antisense Oligonucleotides Targeting Cellular Protein Expression

Caged circular siRNAs for photomodulation of gene expression in cells and mice

(2018) Liangliang Zhang et al.   Chemical Science

Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice

(2018) Liangliang Zhang et al.   Molecular Therapy-Nucleic Acids

The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting

(2017) Dongming Liang et al.   MOLECULAR CELL

RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus

(2017) Xue-Hai Liang et al.   MOLECULAR THERAPY

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Oligonucleotide modifications enhance probe stability for single cell transcriptome in vivo analysis (TIVA)

(2017) S. B. Yeldell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice

(2017) Tina Lucas et al.   Nature Communications

Three-Dimensional Control of DNA Hybridization by Orthogonal Two-Color Two-Photon Uncaging

(2016) Manuela A. H. Fichte et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photo-Tethers for the (Multi-)Cyclic, Conformational Caging of Long Oligonucleotides

(2016) Patrick Seyfried et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors

(2016) Piyush K. Jain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RNA-targeted therapeutics in cancer clinical trials: Current status and future directions

(2016) Pedro Barata et al.   CANCER TREATMENT REVIEWS

Photochemical Regulation of Gene Expression Using Caged siRNAs with Single Terminal Vitamin E Modification

(2015) Yuzhuo Ji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Circular DNA by “Bis-Click” Ligation: Template-Independent Intramolecular Circularization of Oligonucleotides with Terminal Alkynyl Groups Utilizing Bifunctional Azides

(2015) Haozhe Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Caged oligonucleotides for studying biological systems

(2015) Brittani K. Ruble et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Optically triggered immune response through photocaged oligonucleotides

(2015) Jeane M. Govan et al.   TETRAHEDRON LETTERS

Ruthenium-caged antisense morpholinos for regulating gene expression in zebrafish embryos

(2015) Julianne C. Griepenburg et al.   Chemical Science

Nitroreductase-Activatable Morpholino Oligonucleotides for in Vivo Gene Silencing

(2014) Sayumi Yamazoe et al.   ACS Chemical Biology

Sequential Gene Silencing Using Wavelength-Selective Caged Morpholino Oligonucleotides

(2014) Sayumi Yamazoe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue

(2014) Ditte Lovatt et al.   NATURE METHODS

Circular RNAs: diversity of form and function

(2014) Erika Lasda et al.   RNA

Caged oligonucleotides for bidirectional photomodulation of let-7 miRNA in zebrafish embryos

(2013) Julianne C. Griepenburg et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Light-inducible molecular beacons for spatio-temporally highly defined activation

(2013) Jennifer S. Rinne et al.   CHEMICAL COMMUNICATIONS

The synthesis of tetra-modified RNA for the multidimensional control of gene expression via light-activated RNA interference

(2013) Ashish Kala et al.   Nature Protocols

Optochemical control of RNA interference in mammalian cells

(2013) Jeane M. Govan et al.   NUCLEIC ACIDS RESEARCH

Cyclic Caged Morpholinos: Conformationally Gated Probes of Embryonic Gene Function

(2012) Sayumi Yamazoe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Light-Controlled Tools

(2012) Clara Brieke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Caged circular antisense oligonucleotides for photomodulation of RNA digestion and gene expression in cells

(2012) Li Wu et al.   NUCLEIC ACIDS RESEARCH

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

(2011) Samir EL Andaloussi et al.   NUCLEIC ACIDS RESEARCH

Turning the 10-23 DNAzyme On and Off with Light

(2010) Julia L. Richards et al.   CHEMBIOCHEM

Analysis and Optimization of Copper-Catalyzed Azide–Alkyne Cycloaddition for Bioconjugation

(2009) Vu Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Caged siRNAs for Spatiotemporal Control of Gene Silencing

(2009) John P. Casey et al.   MOLECULAR PHARMACEUTICS