Differential Inhibition of APOBEC3 DNA‐Mutator Isozymes by Fluoro‐ and Non‐Fluoro‐Substituted 2′‐Deoxyzebularine Embedded in Single‐Stranded DNA

Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

(2018) S Venkatesan et al.   ANNALS OF ONCOLOGY

Treatment resistance in urothelial carcinoma: an evolutionary perspective

(2018) Panagiotis J. Vlachostergios et al.   Nature Reviews Clinical Oncology

Evaluation of APOBEC3B Recognition Motifs by NMR Reveals Preferred Substrates

(2018) Manjuan Liu et al.   ACS Chemical Biology

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues

(2018) Maksim V. Kvach et al.   BIOCHEMISTRY

Family-Wide Comparative Analysis of Cytidine and Methylcytidine Deamination by Eleven Human APOBEC Proteins

(2017) Fumiaki Ito et al.   JOURNAL OF MOLECULAR BIOLOGY

APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA

(2017) Emily K. Schutsky et al.   NUCLEIC ACIDS RESEARCH

Driving to Cancer on a Four-Lane Expressway

(2017) Lorenzo Galluzzi et al.   TRENDS IN GENETICS

APOBEC3B, a molecular driver of mutagenesis in human cancers

(2017) Jun Zou et al.   Cell and Bioscience

Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity

(2016) In-Ja L. Byeon et al.   BIOCHEMISTRY

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

(2016) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

(2016) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer

(2016) E. K. Law et al.   Science Advances

DNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B

(2015) Y. Fu et al.   BIOCHEMICAL JOURNAL

Characterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine

(2015) Sachini U. Siriwardena et al.   JOURNAL OF MOLECULAR BIOLOGY

APOBECs and virus restriction

(2015) Reuben S. Harris et al.   VIROLOGY

Catalytic Analysis of APOBEC3G Involving Real-Time NMR Spectroscopy Reveals Nucleic Acid Determinants for Deamination

(2015) Keisuke Kamba et al.   PLoS One

Efficient synthesis of 2′-deoxyzebularine and its α-anomer by the silyl method of N-glycosylation. Crystal structures and conformational study in solution

(2014) Katarzyna Ebenryter-Olbinska et al.   CARBOHYDRATE RESEARCH

Elevated APOBEC3B Correlates with Poor Outcomes for Estrogen-Receptor-Positive Breast Cancers

(2014) Anieta M. Sieuwerts et al.   Hormones & Cancer

Increased CDA Expression/Activity in Males Contributes to Decreased Cytidine Analog Half-Life and Likely Contributes to Worse Outcomes with 5-Azacytidine or Decitabine Therapy

(2013) R. Z. Mahfouz et al.   CLINICAL CANCER RESEARCH

The Local Dinucleotide Preference of APOBEC3G Can Be Altered from 5′-CC to 5′-TC by a Single Amino Acid Substitution

(2013) Anurag Rathore et al.   JOURNAL OF MOLECULAR BIOLOGY

Impact of H216 on the DNA Binding and Catalytic Activities of the HIV Restriction Factor APOBEC3G

(2013) S. Harjes et al.   JOURNAL OF VIROLOGY

Efficient Deamination of 5-Methylcytidine and 5-Substituted Cytidine Residues in DNA by Human APOBEC3A Cytidine Deaminase

(2013) Rodolphe Suspène et al.   PLoS One

Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase

(2013) C. S. Nabel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV Restriction Factors and Mechanisms of Evasion

(2013) M. H. Malim et al.   Cold Spring Harbor Perspectives in Medicine

Synthesis and Evaluation of 6-Aza-2′-deoxyuridine Monophosphate Analogs as Inhibitors of Thymidylate Synthases, and as Substrates or Inhibitors of Thymidine Monophosphate Kinase in Mycobacterium tuberculosis

(2012) Martin Kögler et al.   CHEMISTRY & BIODIVERSITY

Methylcytosine and Normal Cytosine Deamination by the Foreign DNA Restriction Enzyme APOBEC3A

(2012) Michael A. Carpenter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation

(2012) Christopher S Nabel et al.   Nature Chemical Biology

Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G

(2012) Priyanga Wijesinghe et al.   NUCLEIC ACIDS RESEARCH

AID Enzymatic Activity Is Inversely Proportional to the Size of Cytosine C5 Orbital Cloud

(2012) Gopinath Rangam et al.   PLoS One

First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G

(2011) Ming Li et al.   ACS Chemical Biology

Determinants of sequence-specificity within human AID and APOBEC3G

(2010) Michael A. Carpenter et al.   DNA REPAIR

Local Sequence Targeting in the AID/APOBEC Family Differentially Impacts Retroviral Restriction and Antibody Diversification

(2010) Rahul M. Kohli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

(2010) Mark D Stenglein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Herpes Simplex Virus-1 DNA Primase: A Remarkably Inaccurate yet Selective Polymerase

(2009) Milan Urban et al.   BIOCHEMISTRY

Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G

(2009) Ayako Furukawa et al.   EMBO JOURNAL

A Portable Hot Spot Recognition Loop Transfers Sequence Preferences from APOBEC Family Members to Activation-induced Cytidine Deaminase

(2009) Rahul M. Kohli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY