Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity

(2016) In-Ja L. Byeon et al.   BIOCHEMISTRY

1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure

(2016) Nadine M. Shaban et al.   JOURNAL OF MOLECULAR BIOLOGY

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

(2016) Serena Nik-Zainal et al.   NATURE

Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity

(2016) Melissa M Matthews et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

(2016) Gabriel J. Starrett et al.   Nature Communications

Crystal structures of APOBEC3G N-domain alone and its complex with DNA

(2016) Xiao Xiao et al.   Nature Communications

Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity

(2016) Melissa M Matthews et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study

(2016) Shumei Yan et al.   Journal of Cancer

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer

(2016) E. K. Law et al.   Science Advances

DNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B

(2015) Y. Fu et al.   BIOCHEMICAL JOURNAL

Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain

(2015) Ke Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma

(2015) Brian A. Walker et al.   JOURNAL OF CLINICAL ONCOLOGY

Structural Insights into HIV-1 Vif-APOBEC3F Interaction

(2015) Masaaki Nakashima et al.   JOURNAL OF VIROLOGY

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

(2015) Kin Chan et al.   NATURE GENETICS

Intrinsic host restrictions to HIV-1 and mechanisms of viral escape

(2015) Viviana Simon et al.   NATURE IMMUNOLOGY

Molecular basis of the attenuated phenotype of human APOBEC3B DNA mutator enzyme

(2015) Vincent Caval et al.   NUCLEIC ACIDS RESEARCH

APOBEC3Bexpression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activation

(2015) David W. Cescon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization

(2015) Markus-Frederik Bohn et al.   STRUCTURE

APOBECs and virus restriction

(2015) Reuben S. Harris et al.   VIROLOGY

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

(2015) C. Swanton et al.   Cancer Discovery

Re-editing the paradigm of Cytidine (C) to Uridine (U) RNA editing

(2015) Nicolas Fossat et al.   RNA Biology

Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer

(2014) Serena Nik-Zainal et al.   NATURE GENETICS

Mechanisms underlying mutational signatures in human cancers

(2014) Thomas Helleday et al.   NATURE REVIEWS GENETICS

A DNA Sequence Recognition Loop on APOBEC3A Controls Substrate Specificity

(2014) Eric C. Logue et al.   PLoS One

A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3′UTR enhances chromosomal DNA damage

(2014) Vincent Caval et al.   Nature Communications

Human APOBEC3 Induced Mutation of Human Immunodeficiency Virus Type-1 Contributes to Adaptation and Evolution in Natural Infection

(2014) Eun-Young Kim et al.   PLoS Pathogens

Elevated APOBEC3B Correlates with Poor Outcomes for Estrogen-Receptor-Positive Breast Cancers

(2014) Anieta M. Sieuwerts et al.   Hormones & Cancer

A Biochemical Analysis Linking APOBEC3A to Disparate HIV-1 Restriction and Skin Cancer

(2013) Phuong Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Local Dinucleotide Preference of APOBEC3G Can Be Altered from 5′-CC to 5′-TC by a Single Amino Acid Substitution

(2013) Anurag Rathore et al.   JOURNAL OF MOLECULAR BIOLOGY

Impact of H216 on the DNA Binding and Catalytic Activities of the HIV Restriction Factor APOBEC3G

(2013) S. Harjes et al.   JOURNAL OF VIROLOGY

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Evidence for APOBEC3B mutagenesis in multiple human cancers

(2013) Michael B Burns et al.   NATURE GENETICS

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

Structural determinants of human APOBEC3A enzymatic and nucleic acid binding properties

(2013) M. Mitra et al.   NUCLEIC ACIDS RESEARCH

APOBEC3G cytosine deamination hotspots are defined by both sequence context and single-stranded DNA secondary structure

(2013) Colleen M. Holtz et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of the DNA Cytosine Deaminase APOBEC3F: The Catalytically Active and HIV-1 Vif-Binding Domain

(2013) Markus-Frederik Bohn et al.   STRUCTURE

NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity

(2013) In-Ja L. Byeon et al.   Nature Communications

HIV Restriction Factors and Mechanisms of Evasion

(2013) M. H. Malim et al.   Cold Spring Harbor Perspectives in Medicine

Chromosome Translocation, B Cell Lymphoma, and Activation-Induced Cytidine Deaminase

(2012) Davide F. Robbiani et al.   Annual Review of Pathology-Mechanisms of Disease

Conformational Free-Energy Landscapes for a Peptide in Saline Environments

(2012) Timothy J. Gaborek et al.   BIOPHYSICAL JOURNAL

Methylcytosine and Normal Cytosine Deamination by the Foreign DNA Restriction Enzyme APOBEC3A

(2012) Michael A. Carpenter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The APOBEC3C crystal structure and the interface for HIV-1 Vif binding

(2012) Shingo Kitamura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G

(2011) Ming Li et al.   ACS Chemical Biology

Phosphorylation Directly Regulates the Intrinsic DNA Cytidine Deaminase Activity of Activation-induced Deaminase and APOBEC3G Protein

(2011) Zachary L. Demorest et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experimental phasing withSHELXC/D/E: combining chain tracing with density modification

(2010) George M. Sheldrick   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Determinants of sequence-specificity within human AID and APOBEC3G

(2010) Michael A. Carpenter et al.   DNA REPAIR

Local Sequence Targeting in the AID/APOBEC Family Differentially Impacts Retroviral Restriction and Antibody Diversification

(2010) Rahul M. Kohli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID

(2010) Meng Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities

(2010) Y. Bulliard et al.   JOURNAL OF VIROLOGY

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

(2010) Mark D Stenglein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

(2010) Eric W. Refsland et al.   NUCLEIC ACIDS RESEARCH

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Dissecting APOBEC3G Substrate Specificity by Nucleoside Analog Interference

(2009) Jason W. Rausch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining APOBEC3 Expression Patterns in Human Tissues and Hematopoietic Cell Subsets

(2009) F. A. Koning et al.   JOURNAL OF VIROLOGY

Deaminase-Independent Inhibition of Parvoviruses by the APOBEC3A Cytidine Deaminase

(2009) Iñigo Narvaiza et al.   PLoS Pathogens

Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

(2008) Lauren G. Holden et al.   NATURE

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

(2008) Kuan-Ming Chen et al.   NATURE

Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif

(2008) Kotaro Shirakawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The tektin family of microtubule-stabilizing proteins

(2008) Linda A Amos   GENOME BIOLOGY