Structural determinants of human APOBEC3A enzymatic and nucleic acid binding properties

APOBEC3 Cytidine Deaminases in Double-Strand DNA Break Repair and Cancer Promotion

(2013) R. Nowarski et al.   CANCER RESEARCH

Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination

(2013) Lela Lackey et al.   CELL CYCLE

Endogenous APOBEC3A DNA Cytosine Deaminase Is Cytoplasmic and Nongenotoxic

(2013) Allison M. Land et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Local Dinucleotide Preference of APOBEC3G Can Be Altered from 5′-CC to 5′-TC by a Single Amino Acid Substitution

(2013) Anurag Rathore et al.   JOURNAL OF MOLECULAR BIOLOGY

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid-binding protein

(2013) Kathy R. Chaurasiya et al.   Nature Chemistry

Evidence for APOBEC3B mutagenesis in multiple human cancers

(2013) Michael B Burns et al.   NATURE GENETICS

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

Binding of RNA by APOBEC3G controls deamination-independent restriction of retroviruses

(2013) Kasandra Bélanger et al.   NUCLEIC ACIDS RESEARCH

Efficient Deamination of 5-Methylcytidine and 5-Substituted Cytidine Residues in DNA by Human APOBEC3A Cytidine Deaminase

(2013) Rodolphe Suspène et al.   PLoS One

Retroviral Restriction Factor APOBEC3G Delays the Initiation of DNA Synthesis by HIV-1 Reverse Transcriptase

(2013) Madison B. Adolph et al.   PLoS One

Human APOBEC3A Isoforms Translocate to the Nucleus and Induce DNA Double Strand Breaks Leading to Cell Stress and Death

(2013) Bianka Mussil et al.   PLoS One

Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminase

(2013) C. S. Nabel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase

(2013) G. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity

(2013) In-Ja L. Byeon et al.   Nature Communications

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

(2013) Benjamin JM Taylor et al.   eLife

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

AID and Apobec3G haphazard deamination and mutational diversity

(2012) Malgorzata Jaszczur et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Methylcytosine and Normal Cytosine Deamination by the Foreign DNA Restriction Enzyme APOBEC3A

(2012) Michael A. Carpenter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Tribbles 3 Protects Nuclear DNA from Cytidine Deamination by APOBEC3A

(2012) Marie-Ming Aynaud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Analysis of Hypermutation by the Deoxycytidine Deaminase APOBEC3A

(2012) Robin P. Love et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APOBEC3A, APOBEC3B, and APOBEC3H Haplotype 2 Restrict Human T-Lymphotropic Virus Type 1

(2012) M. Ooms et al.   JOURNAL OF VIROLOGY

Suppression of HIV-1 Infection by APOBEC3 Proteins in Primary Human CD4+T Cells Is Associated with Inhibition of Processive Reverse Transcription as Well as Excessive Cytidine Deamination

(2012) Kieran Gillick et al.   JOURNAL OF VIROLOGY

Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions

(2012) Steven A. Roberts et al.   MOLECULAR CELL

The APOBEC3C crystal structure and the interface for HIV-1 Vif binding

(2012) Shingo Kitamura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G

(2012) Priyanga Wijesinghe et al.   NUCLEIC ACIDS RESEARCH

APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells

(2012) Masanobu Shinohara et al.   Scientific Reports

APOBEC3A can activate the DNA damage response and cause cell-cycle arrest

(2011) Sébastien Landry et al.   EMBO REPORTS

Deaminase Activity on Single-stranded DNA (ssDNA) Occursin Vitrowhen APOBEC3G Cytidine Deaminase Forms Homotetramers and Higher-order Complexes

(2011) William M. McDougall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein localization in disease and therapy

(2011) M.-C. Hung et al.   JOURNAL OF CELL SCIENCE

Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1

(2011) J. F. Hultquist et al.   JOURNAL OF VIROLOGY

Target Cell-Mediated Editing of HIV-1 cDNA by APOBEC3 Proteins in Human Macrophages

(2011) F. A. Koning et al.   JOURNAL OF VIROLOGY

Replication Protein A (RPA) Hampers the Processive Action of APOBEC3G Cytosine Deaminase on Single-Stranded DNA

(2011) Artem G. Lada et al.   PLoS One

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

(2011) R. Suspene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of HIV-1 nucleocapsid protein in HIV-1 reverse transcription

(2011) Judith G Levin et al.   RNA Biology

Requirements for efficient minus strand strong-stop DNA transfer in human immunodeficiency virus 1

(2011) Dorota Piekna-Przybylska et al.   RNA Biology

APOBEC3A Is a Specific Inhibitor of the Early Phases of HIV-1 Infection in Myeloid Cells

(2011) Gregory Berger et al.   PLoS Pathogens

Determinants of sequence-specificity within human AID and APOBEC3G

(2010) Michael A. Carpenter et al.   DNA REPAIR

Atomic Force Microscopy Studies Provide Direct Evidence for Dimerization of the HIV Restriction Factor APOBEC3G

(2010) Luda S. Shlyakhtenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate Immune Signaling Induces High Levels of TC-specific Deaminase Activity in Primary Monocyte-derived Cells through Expression of APOBEC3A Isoforms

(2010) Beth K. Thielen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local Sequence Targeting in the AID/APOBEC Family Differentially Impacts Retroviral Restriction and Antibody Diversification

(2010) Rahul M. Kohli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Analyses Point to a Polynucleotide-Accommodating Groove Essential for APOBEC3A Restriction Activities

(2010) Y. Bulliard et al.   JOURNAL OF VIROLOGY

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

(2010) Mark D Stenglein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

(2010) Eric W. Refsland et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces

(2010) Shivender M.D. Shandilya et al.   STRUCTURE

Crosstalk between genetic and epigenetic information through cytosine deamination

(2010) Richard Chahwan et al.   TRENDS IN GENETICS

Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: Biological implications

(2010) Tiyun Wu et al.   VIROLOGY

APOBEC3 Proteins Inhibit LINE-1 Retrotransposition in the Absence of ORF1p Binding

(2009) Nika Lovšin et al.   Annals of the New York Academy of Sciences

The current structural and functional understanding of APOBEC deaminases

(2009) Ronda Bransteitter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multiple human single-stranded DNA binding proteins function in genome maintenance: structural, biochemical and functional analysis

(2009) Derek J. Richard et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G

(2009) Ayako Furukawa et al.   EMBO JOURNAL

An Extended Structure of the APOBEC3G Catalytic Domain Suggests a Unique Holoenzyme Model

(2009) Elena Harjes et al.   JOURNAL OF MOLECULAR BIOLOGY

Defining APOBEC3 Expression Patterns in Human Tissues and Hematopoietic Cell Subsets

(2009) F. A. Koning et al.   JOURNAL OF VIROLOGY

Deaminase-Independent Inhibition of Parvoviruses by the APOBEC3A Cytidine Deaminase

(2009) Iñigo Narvaiza et al.   PLoS Pathogens

RNA-Dependent Oligomerization of APOBEC3G Is Required for Restriction of HIV-1

(2009) Hendrik Huthoff et al.   PLoS Pathogens

The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous Retroelements

(2008) Ya-Lin Chiu et al.   Annual Review of Immunology

A Model for Oligomeric Regulation of APOBEC3G Cytosine Deaminase-dependent Restriction of HIV

(2008) Linda Chelico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

(2008) Lauren G. Holden et al.   NATURE

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

(2008) Kuan-Ming Chen et al.   NATURE

APOBEC proteins and intrinsic resistance to HIV-1 infection

(2008) M. H Malim   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Evidence for Editing of Human Papillomavirus DNA by APOBEC3 in Benign and Precancerous Lesions

(2008) J.-P. Vartanian et al.   SCIENCE

APOBEC3G Inhibits Elongation of HIV-1 Reverse Transcripts

(2008) Kate N. Bishop et al.   PLoS Pathogens