Haemoglobin degradation underpins the sensitivity of early ring stagePlasmodium falciparumto artemisinins

Replication ofPlasmodiumin reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance

(2015) Jing-wen Lin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker

(2015) Kyaw M Tun et al.   LANCET INFECTIOUS DISEASES

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

Genetic architecture of artemisinin-resistant Plasmodium falciparum

(2015) Olivo Miotto et al.   NATURE GENETICS

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

(2015) Con Dogovski et al.   PLOS BIOLOGY

PTEX is an essential nexus for protein export in malaria parasites

(2014) Brendan Elsworth et al.   NATURE

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

(2014) S. Mok et al.   SCIENCE

Parasite maturation and host serum iron influence the labile iron pool of erythrocyte stagePlasmodium falciparum

(2013) Martha Clark et al.   BRITISH JOURNAL OF HAEMATOLOGY

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

(2013) Nectarios Klonis et al.   CURRENT OPINION IN MICROBIOLOGY

Malaria

(2013) Nicholas J White et al.   LANCET

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies

(2013) Benoit Witkowski et al.   LANCET INFECTIOUS DISEASES

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Inducible Knockdown of Plasmodium Gene Expression Using the glmS Ribozyme

(2013) Parichat Prommana et al.   PLoS One

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

(2013) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Antimalarial Natural Product Symplostatin 4 Is a Nanomolar Inhibitor of the Food Vacuole Falcipains

(2012) Sara Christina Stolze et al.   CHEMISTRY & BIOLOGY

Interactions between Artemisinins and other Antimalarial Drugs in Relation to the Cofactor Model-A Unifying Proposal for Drug Action

(2012) Richard K. Haynes et al.   ChemMedChem

Plasmodium falciparum resistance to cytocidal versus cytostatic effects of chloroquine

(2011) Michelle F. Paguio et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

(2011) S. A. Charman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular architecture of Plasmodium falciparum-infected erythrocytes

(2010) Eric Hanssen et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum

(2010) N. A. Bakar et al.   JOURNAL OF CELL SCIENCE

Biological Actions of Artemisinin: Insights from Medicinal Chemistry Studies

(2010) Jian Li et al.   MOLECULES

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

(2010) Juan Wang et al.   PLoS One

Malaria's Drug Miracle in Danger

(2010) M. Enserink   SCIENCE

Plasmodium Food Vacuole Plasmepsins Are Activated by Falcipains

(2008) Mark E. Drew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Highly Efficient Depletion Strategy for the Two Most Abundant Erythrocyte Soluble Proteins Improves Proteome Coverage Dramatically

(2008) Jeffrey H. Ringrose et al.   JOURNAL OF PROTEOME RESEARCH

Stage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopy

(2008) Bojana Gligorijevic et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Haemozoin formation

(2007) Timothy J. Egan   MOLECULAR AND BIOCHEMICAL PARASITOLOGY