Review
Immunology
Ruiyi Zhang, V. Wee Yong, Mengzhou Xue
Summary: Intracerebral hemorrhage (ICH) is a subtype of stroke with a poor prognosis. Despite numerous pre-clinical studies and clinical trials, effective treatment for ICH patients is still lacking. Minocycline, a neuroprotective pharmaceutical, shows promise in alleviating secondary brain injury after ICH. This review discusses the protective mechanisms, limitations, and clinical trial perspectives of minocycline in ICH, aiming to facilitate further research.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Katherine Holste, Fan Xia, Hugh J. L. Garton, Shu Wan, Ya Hua, Richard F. Keep, Guohua Xi
Summary: Intracerebral hemorrhage (ICH) leads to activation of the complement cascade, resulting in brain edema/injury, but inhibition of specific components of the complement cascade can reduce edema and improve functional outcomes. Additionally, complement plays a significant role in neurologic recovery after ICH.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Ronda Lun, Vignan Yogendrakumar, Greg Walker, Michel Shamy, Robert Fahed, Adnan Qureshi, Dar Dowlatshahi
Summary: The study validates revised definitions of hematoma expansion incorporating intraventricular hemorrhage expansion for predicting poor outcome, outperforming conventional definitions even after accounting for care limitations.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Review
Immunology
Yuanyuan Li, Chenxi Tao, Na An, Haoqi Liu, Zhenhong Liu, Hongrui Zhang, Yikun Sun, Yanwei Xing, Yonghong Gao
Summary: Intracerebral hemorrhage (ICH) is a stroke subtype characterized by non-traumatic rupture of blood vessels in the brain, resulting in blood pooling in the brain parenchyma. ICH remains a significant contributor to stroke-related mortality and has various complex pathological damage including mechanical damage, inflammatory response, and complement activation. This review summarizes the pathological mechanisms of brain injury after ICH, particularly focusing on the role of complement and its related mechanisms, as well as provides an overview of complement-targeted therapies for ICH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Nils Schweingruber, Marius Mader, Anton Wiehe, Frank Roeder, Jennifer Goettsche, Stefan Kluge, Manfred Westphal, Patrick Czorlich, Christian Gerloff
Summary: The evolution of intracranial pressure in critically ill patients is difficult to predict. Machine learning models can assist in the clinical management of patients undergoing invasive ICP monitoring. A study used recurrent machine learning models to predict critical increases in ICP and validated the models in two independent datasets.
Article
Biochemistry & Molecular Biology
John C. O'Donnell, Kevin D. Browne, Svetlana Kvint, Leah Makaron, Michael R. Grovola, Saarang Karandikar, Todd J. Kilbaugh, D. Kacy Cullen, Dmitriy Petrov
Summary: Neurocritical care has significant impact on outcomes after brain injury, but is rarely used in preclinical studies. We created a neurointensive care unit for swine to account for neurocritical care, collect monitoring data, and validate therapeutics in this unique space. Our multidisciplinary team developed neurocritical care techniques and medical management for swine following brain injury. Incorporating neurocritical care in swine studies will improve translational research for brain injury.
Review
Clinical Neurology
Teodor M. Svedung Wettervik, Anders Lewen, Per Enblad
Summary: Neurointensive care plays a crucial role in preventing secondary insults and reducing secondary brain injury. Traditional management focuses on avoiding high intracranial pressure and maintaining adequate cerebral perfusion pressure, but traumatic brain injury is highly heterogeneous. Introduction of multimodality monitoring has enhanced understanding of complex pathophysiology.
FRONTIERS IN NEUROLOGY
(2021)
Review
Nutrition & Dietetics
Yuan Zhang, Wanpeng Yu, Christopher Flynn, Wenguang Chang, Lei Zhang, Man Wang, Wanhong Zheng, Peifeng Li
Summary: The pathophysiological process of intracerebral hemorrhage (ICH) involves complex mechanisms such as apoptosis, oxidative stress, and inflammation. Inflammatory response, as a key factor, plays a crucial role in the pathological process of acute brain injury and is associated with patient prognosis. Abnormal or dysregulated inflammatory responses can worsen cellular damage in the injured brain tissue. The NLRP3 inflammasome, a multiprotein complex in the cytosol, is activated after ICH, leading to neuroinflammation and aggravated brain edema. Additionally, the gut microbiota has been found to be essential in NLRP3 inflammasome activation. Changes in gut microbiota diversity and species influence neuroinflammation through NLRP3 inflammasome activation and the release of inflammatory cytokines. Conversely, the composition of the gut microbiota can be influenced by NLRP3 inflammasome activation. Therefore, targeting the microbe-gut-brain axis via NLRP3 inflammasome regulation could be a novel approach to protect against secondary brain injury in ICH patients.
Article
Clinical Neurology
Audrey C. Leasure, Lindsey R. Kuohn, Kevin N. Vanent, Matthew B. Bevers, W. Taylor Kimberly, Thorsten Steiner, Stephan A. Mayer, Charles C. Matouk, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth
Summary: Higher admission IL-6 levels in patients with spontaneous intracerebral hemorrhage are associated with worse 90-day functional outcome, larger ICH volume, and larger perihematomal edema volume.
Review
Clinical Neurology
Zhe Li, Suliman Khan, Yang Liu, Ruixue Wei, V. Wee Yong, Mengzhou Xue
Summary: Stroke is the second leading cause of death worldwide, and intracerebral hemorrhage (ICH) is a type of stroke associated with poor neurological outcomes and high mortality. Experimental therapies have shown potential in improving functional outcomes for ICH patients.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Lingui Gu, Mingjiang Sun, Ruihao Li, Yihao Tao, Xu Luo, Xingyu Zhang, Ye Yuan, Zongyi Xie
Summary: This review outlines the role of microglial pyroptosis in the pathological process of intracerebral hemorrhage (ICH) and highlights the potential of targeted strategies to inhibit microglial pyroptosis as a therapeutic approach.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Immunology
Lingui Gu, Mingjiang Sun, Ruihao Li, Xingyu Zhang, Yihao Tao, Ye Yuan, Xu Luo, Zongyi Xie
Summary: Didymin treatment significantly improved neurobehavioral performance, reduced BBB disruption and brain water content, and mitigated microglial activation and neutrophil infiltration in the peri-hematoma tissue after ICH. The upregulation of Rkip expression by Didymin may play a key role in alleviating microglial pyroptosis and neuroinflammation through the Asc/Caspase-1/GSDMD pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Josephine M. Thomas, Irene Louca, Faye Bolan, Oana-Roxana Sava, Stuart M. Allan, Catherine B. Lawrence, Emmanuel Pinteaux
Summary: Intracerebral hemorrhage (ICH) is a deadly type of stroke with no approved restorative interventions, highlighting an unmet need. Similar to ischemic stroke (IS) and traumatic brain injury (TBI), ICH shares pathological features such as brain tissue loss, disruption of the blood-brain barrier, and inflammatory response. New biomaterials like hydrogels have shown therapeutic potential in IS and TBI, but research on their use in ICH therapy is still in its early stages.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Neurosciences
Guoqiang Yang, Xuehui Fan, Maryam Mazhar, Sijin Yang, Houping Xu, Nathupakorn Dechsupa, Li Wang
Summary: Intracerebral hemorrhage (ICH), a subtype of stroke with high mortality and disability rates, has a major socioeconomic burden, affecting two million people worldwide. Mesenchymal stem cells (MSCs) have shown potential in ICH treatment due to their neuroprotective, anti-inflammatory, and angiogenesis properties. This research field is important for developing new therapeutic strategies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jingchen Li, Xiaoyun Wu, Yanbo He, Song Wu, Erkun Guo, Yan Feng, Jipeng Yang, Jianliang Li
Summary: The study found that in patients with intracerebral hemorrhage, PINK1 mRNA was upregulated while its protein expression was downregulated. PINK1 protects against intracerebral hemorrhage-induced brain injury by promoting mitochondrial autophagy in microglial cells. Overexpression of PINK1 can rescue behavioral disorders induced by intracerebral hemorrhage.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)