Dysregulation of Complement System and CD4+ T Cell Activation Pathways Implicated in Allergic Response

Combined Multivariate and Pathway Analyses Show That Allergen-Induced Gene Expression Changes in CD4+ T Cells Are Reversed by Glucocorticoids

(2012) Yelin Zhao et al.   PLoS One

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

(2012) Adaikalavan Ramasamy et al.   PLoS One

Negative Regulation of Pulmonary Th17 Responses by C3a Anaphylatoxin during Allergic Inflammation in Mice

(2012) Hoyong Lim et al.   PLoS One

Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms

(2012) Fredrik Barrenäs et al.   GENOME BIOLOGY

HTSanalyzeR: an R/Bioconductor package for integrated network analysis of high-throughput screens

(2011) X. Wang et al.   BIOINFORMATICS

Decay-accelerating factor regulates T-cell immunity in the context of inflammation by influencing costimulatory molecule expression on antigen-presenting cells

(2011) C. Fang et al.   BLOOD

Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets

(2011) Q. Xiong et al.   GENOME RESEARCH

A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order

(2011) Adaikalavan Ramasamy et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

(2011) Lavinia Paternoster et al.   NATURE GENETICS

The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex

(2011) Gary M Hunninghake et al.   BMC Pulmonary Medicine

Pervasive Sharing of Genetic Effects in Autoimmune Disease

(2011) Chris Cotsapas et al.   PLoS Genetics

Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology

(2011) Elizabeth J. Rossin et al.   PLoS Genetics

A pathway-based approach to find novel markers of local glucocorticoid treatment in intermittent allergic rhinitis

(2010) H. Wang et al.   ALLERGY

Distinct characteristics of seasonal (Bet v 1) vs. perennial (Der p 1/Der p 2) allergen-specific CD4+T cell responses

(2010) E. Wambre et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation

(2010) H. Wang et al.   CLINICAL AND EXPERIMENTAL ALLERGY

A complex role for complement in allergic asthma

(2010) Xun Zhang et al.   Expert Review of Clinical Immunology

A functional complement system is required for normal T helper cell differentiation

(2010) Pirkka T. Pekkarinen et al.   IMMUNOBIOLOGY

Coordination between Cell Cycle Progression and Cell Fate Decision by the p53 and E2F1 Pathways in Response to DNA Damage

(2010) Xiao-Peng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lck Mediates Th2 Differentiation through Effects on T-bet and GATA-3

(2010) K. L. Kemp et al.   JOURNAL OF IMMUNOLOGY

Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma

(2010) Stephane Lajoie et al.   NATURE IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study

(2010) K. Zhang et al.   NUCLEIC ACIDS RESEARCH

Module Discovery by Exhaustive Search for Densely Connected, Co-Expressed Regions in Biomolecular Interaction Networks

(2010) Recep Colak et al.   PLoS One

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

(2010) Daniele Merico et al.   PLoS One

Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits

(2010) Ayellet V. Segrè et al.   PLoS Genetics

Using the ratio of means as the effect size measure in combining results of microarray experiments

(2009) Pingzhao Hu et al.   BMC Systems Biology

The complement system in systemic autoimmune disease

(2009) Min Chen et al.   JOURNAL OF AUTOIMMUNITY

Death receptor signal transducers: nodes of coordination in immune signaling networks

(2009) Nicholas S Wilson et al.   NATURE IMMUNOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Short communication: Analysis of CD4+ T-cell gene expression in allergic subjects using two different microarray platforms

(2008) N. N. Hansel et al.   ALLERGY

A comparison of meta-analysis methods for detecting differentially expressed genes in microarray experiments

(2008) Fangxin Hong et al.   BIOINFORMATICS

Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis

(2008) P. N. Lalli et al.   BLOOD

The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils

(2008) M. Kneidinger et al.   BLOOD

Protein networks in disease

(2008) T. Ideker et al.   GENOME RESEARCH

Overexpression of the anaphylatoxin receptors, complement anaphylatoxin 3a receptor and complement anaphylatoxin 5a receptor, in the nasal mucosa of patients with mild and severe persistent allergic rhinitis

(2008) Sung Whan Jun et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY