Metabolic modeling of single bronchoalveolar macrophages reveals regulators of hyperinflammation in COVID-19

Glycolytic inhibitor 2-deoxy-d-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virions

(2022) Anant Narayan Bhatt et al.   LIFE SCIENCES

2-Deoxy-D-Glucose and its Derivatives for the COVID-19 Treatment: An Update

(2022) Zoufang Huang et al.   Frontiers in Pharmacology

A shift in lung macrophage composition is associated with COVID-19 severity and recovery

(2022) Steven T. Chen et al.   Science Translational Medicine

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

(2021) Els Wauters et al.   CELL RESEARCH

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

(2021) Xianwen Ren et al.   CELL

Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

(2021) Nan Xiao et al.   Nature Communications

Metabolic programs define dysfunctional immune responses in severe COVID-19 patients

(2021) Elizabeth A. Thompson et al.   Cell Reports

Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection

(2021) Piyush Nanda et al.   PLoS Computational Biology

Prescription of glucose-lowering therapies and risk of COVID-19 mortality in people with type 2 diabetes: a nationwide observational study in England

(2021) Kamlesh Khunti et al.   Lancet Diabetes & Endocrinology

Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

(2021) Allon Wagner et al.   CELL

Nutrition in the Actual COVID-19 Pandemic. A Narrative Review

(2021) Vicente Javier Clemente-Suárez et al.   Nutrients

Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1

(2021) Theodore J. Cory et al.   Frontiers in Immunology

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

(2020) Bo Shen et al.   CELL

Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients

(2020) Pierre Bost et al.   CELL

Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis

(2020) Katerina Rohlenova et al.   Cell Metabolism

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

(2020) Lihua Zhu et al.   Cell Metabolism

Immunometabolism: From basic mechanisms to translation

(2020) Liza Makowski et al.   IMMUNOLOGICAL REVIEWS

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

(2020) Jonas Schulte-Schrepping et al.   CELL

Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19

(2020) Aymeric Silvin et al.   CELL

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

(2020) Ana Campos Codo et al.   Cell Metabolism

Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis

(2020) Jin-Wen Song et al.   Cell Metabolism

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

(2020) Aaron J. Wilk et al.   NATURE MEDICINE

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

(2020) Divij Mathew et al.   SCIENCE

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

A dynamic COVID-19 immune signature includes associations with poor prognosis

(2020) Adam G. Laing et al.   NATURE MEDICINE

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

(2020) Prabhu S. Arunachalam et al.   SCIENCE

The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing

(2020) Gang Xu et al.   Cell Discovery

PPARγ Cistrome Repression during Activation of Lung Monocyte-Macrophages in Severe COVID-19

(2020) Christophe Desterke et al.   iScience

dittoSeq: universal user-friendly single-cell and bulk RNA sequencing visualization toolkit

(2020) Daniel G Bunis et al.   BIOINFORMATICS

FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2

(2020) Alina Renz et al.   BIOINFORMATICS

Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19

(2020) Yapeng Su et al.   CELL

Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies

(2020) Mirko Cortese et al.   Cell Host & Microbe

A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection

(2020) Peng Wang et al.   Cell Death & Disease

Integration of single-cell RNA-seq data into population models to characterize cancer metabolism

(2019) Chiara Damiani et al.   PLoS Computational Biology

The single-cell transcriptional landscape of mammalian organogenesis

(2019) Junyue Cao et al.   NATURE

PPAR-γ in macrophages limits pulmonary inflammation and promotes host recovery following respiratory viral infection

(2019) Su Huang et al.   JOURNAL OF VIROLOGY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis

(2019) Christina Morse et al.   EUROPEAN RESPIRATORY JOURNAL

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

In vivo Differentiation of Human Monocytes

(2019) Alice Coillard et al.   Frontiers in Immunology

Metabolic landscape of the tumor microenvironment at single cell resolution

(2019) Zhengtao Xiao et al.   Nature Communications

Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function

(2019) Alexander Lercher et al.   IMMUNITY

Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors

(2018) Laleh Haghverdi et al.   NATURE BIOTECHNOLOGY

Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization

(2018) Sujin Kang et al.   NATURE IMMUNOLOGY

An accurate and robust imputation method scImpute for single-cell RNA-seq data

(2018) Wei Vivian Li et al.   Nature Communications

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation

(2018) Feilong Wang et al.   Cell Metabolism

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

(2016) Tetsuya Kimura et al.   Nature Communications

Metabolic functions of FABPs—mechanisms and therapeutic implications

(2015) Gökhan S. Hotamisligil et al.   Nature Reviews Endocrinology

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

(2014) Nathalie Esser et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Improving metabolic flux predictions using absolute gene expression data

(2012) Dave Lee et al.   BMC Systems Biology

Human Dendritic Cell Subsets from Spleen and Blood Are Similar in Phenotype and Function but Modified by Donor Health Status

(2011) D. Mittag et al.   JOURNAL OF IMMUNOLOGY

Functional integration of a metabolic network model and expression data without arbitrary thresholding

(2010) Paul A. Jensen et al.   BIOINFORMATICS

What is flux balance analysis?

(2010) Jeffrey D Orth et al.   NATURE BIOTECHNOLOGY

Network-based prediction of human tissue-specific metabolism

(2008) Tomer Shlomi et al.   NATURE BIOTECHNOLOGY