Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease

TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau

(2021) Peter E. A. Ash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components

(2021) Evan Lester et al.   NEURON

Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer’s Disease

(2021) Qi Guo et al.   Frontiers in Molecular Neuroscience

Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes.

(2020) Rebecca L. Kow et al.   NEUROBIOLOGY OF DISEASE

RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction

(2020) Mauro Montalbano et al.   Nature Communications

SON and SRRM2 are essential for nuclear speckle formation

(2020) İbrahim Avşar Ilik et al.   eLife

Nuclear Transport Deficits in Tau-Related Neurodegenerative Diseases

(2020) Lisa Diez et al.   Frontiers in Neurology

The liquid nucleome – phase transitions in the nucleus at a glance

(2019) Amy R. Strom et al.   JOURNAL OF CELL SCIENCE

Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau

(2019) Sarah M. Waldherr et al.   Nature Communications

Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease

(2019) Yi-Chen Hsieh et al.   Cell Reports

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

(2019) Jeanna M. Wheeler et al.   Science Translational Medicine

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease

(2018) Isaac Bishof et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

(2018) Bahareh Eftekharzadeh et al.   NEURON

RNA binding proteins co-localize with small tau inclusions in tauopathy

(2018) Brandon F. Maziuk et al.   Acta Neuropathologica Communications

TIA1 regulates the generation and response to toxic tau oligomers

(2018) Lulu Jiang et al.   ACTA NEUROPATHOLOGICA

Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila

(2018) Garrett L. Cornelison et al.   AGING CELL

The intellectual disability gene PQBP1 rescues Alzheimer’s disease pathology

(2018) Hikari Tanaka et al.   MOLECULAR PSYCHIATRY

Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer’s disease

(2018) Urmi Sengupta et al.   Acta Neuropathologica Communications

RNA stores tau reversibly in complex coacervates

(2017) Xuemei Zhang et al.   PLOS BIOLOGY

Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression

(2016) Chadwick M. Hales et al.   PROTEOMICS

RNA Binds to Tau Fibrils and Sustains Template-Assisted Growth

(2015) Paul D. Dinkel et al.   BIOCHEMISTRY

Aggregates of Small Nuclear Ribonucleic Acids (snRNAs) in Alzheimer's Disease

(2014) Chadwick M. Hales et al.   BRAIN PATHOLOGY

Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation

(2013) J. F. Abisambra et al.   JOURNAL OF NEUROSCIENCE

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease

(2013) B. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RSR-2, the Caenorhabditis elegans Ortholog of Human Spliceosomal Component SRm300/SRRM2, Regulates Development by Influencing the Transcriptional Machinery

(2013) Laura Fontrodona et al.   PLoS Genetics

MSUT2 is a determinant of susceptibility to tau neurotoxicity

(2011) Chris R. Guthrie et al.   HUMAN MOLECULAR GENETICS

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies

(2011) Diana AT Nijholt et al.   JOURNAL OF PATHOLOGY

The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo

(2010) Carin A. Loewen et al.   PLoS One

Nuclear Speckles

(2010) D. L. Spector et al.   Cold Spring Harbor Perspectives in Biology

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

(2009) Jeroen J.M. Hoozemans et al.   AMERICAN JOURNAL OF PATHOLOGY

SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans

(2009) Chris R. Guthrie et al.   HUMAN MOLECULAR GENETICS

A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300

(2009) M. Khanna et al.   RNA