Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump

An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii

(2022) Christopher E. Morgan et al.   mBio

Cryoelectron Microscopy Structures of AdeB Illuminate Mechanisms of Simultaneous Binding and Exporting of Substrates

(2021) Christopher E. Morgan et al.   mBio

Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii

(2021) Zhemin Zhang et al.   mBio

Key Takeaways From the U.S. CDC’s 2019 Antibiotic Resistance Threats Report for Frontline Providers

(2020) Sameer S. Kadri   CRITICAL CARE MEDICINE

Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance

(2020) Meinan Lyu et al.   mBio

Could Dampening Expression of the Neisseria gonorrhoeae mtrCDE-Encoded Efflux Pump Be a Strategy To Preserve Currently or Resurrect Formerly Used Antibiotics To Treat Gonorrhea?

(2019) Shaochun Chen et al.   mBio

Multidrug Resistance in Neisseria gonorrhoeae: Identification of Functionally Important Residues in the MtrD Efflux Protein

(2019) Mohsen Chitsaz et al.   mBio

Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms

(2018) Evan F. Haney et al.   Scientific Reports

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Heteroresistance to the model antimicrobial peptide polymyxin B in the emerging Neisseria meningitidis lineage 11.2 urethritis clade: mutations in the pilMNOPQ operon

(2018) Yih-Ling Tzeng et al.   MOLECULAR MICROBIOLOGY

Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump Locus

(2018) Corinne E. Rouquette-Loughlin et al.   mBio

Antimicrobial peptides as potential anti-biofilm agents against multidrug-resistant bacteria

(2017) Pooi Yin Chung et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

(2017) Yufeng Yu et al.   Nature Communications

New Perspectives in Biofilm Eradication

(2017) Heidi Wolfmeier et al.   ACS Infectious Diseases

D-Enantiomeric Peptides that Eradicate Wild-Type and Multidrug-Resistant Biofilms and Protect against Lethal Pseudomonas aeruginosa Infections

(2015) César de la Fuente-Núñez et al.   CHEMISTRY & BIOLOGY

High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides

(2015) Evan F. Haney et al.   PEPTIDES

Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting

(2015) Lori Newman et al.   PLoS One

A Broad-Spectrum Antibiofilm Peptide Enhances Antibiotic Action against Bacterial Biofilms

(2014) Fany Reffuveille et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synergistic Effects of Antimicrobial Peptides and Antibiotics against Clostridium difficile

(2014) Sabine Nuding et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crystal Structure of the Open State of the Neisseria gonorrhoeae MtrE Outer Membrane Channel

(2014) Hsiang-Ting Lei et al.   PLoS One

Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump

(2014) Jani Reddy Bolla et al.   PLoS One

Antimicrobial peptides and proteins in mycobacterial therapy: Current status and future prospects

(2014) Avinash Padhi et al.   TUBERCULOSIS

Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response

(2014) César de la Fuente-Núñez et al.   PLoS Pathogens

Targeting Mycobacterium tuberculosis and Other Microbial Pathogens Using Improved Synthetic Antibacterial Peptides

(2013) Santiago Ramón-García et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effective Adjunctive Therapy by an Innate Defense Regulatory Peptide in a Preclinical Model of Severe Malaria

(2012) A. H. Achtman et al.   Science Translational Medicine

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

(2011) Ryosuke Nakashima et al.   NATURE

Opening of the Outer Membrane Protein Channel in Tripartite Efflux Pumps Is Induced by Interaction with the Membrane Fusion Partner

(2010) Thamarai K. Janganan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

The Human Host Defense Peptide LL-37 Interacts with Neisseria meningitidis Capsular Polysaccharides and Inhibits Inflammatory Mediators Release

(2010) Susu M. Zughaier et al.   PLoS One

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Crystal Structure of the Multidrug Exporter MexB from Pseudomonas aeruginosa

(2009) Gaby Sennhauser et al.   JOURNAL OF MOLECULAR BIOLOGY

A New Generation of Peptide-based Inhibitors Targeting HIV-1 Reverse Transcriptase Conformational Flexibility

(2008) Audrey Agopian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design of Peptide-based Inhibitors for Human Immunodeficiency Virus Type 1 Strains Resistant to T-20

(2008) Kazuki Izumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinically relevant mutations that cause derepression of theNeisseria gonorrhoeaeMtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance andin vivofitness

(2008) Douglas M. Warner et al.   MOLECULAR MICROBIOLOGY