Amygdalin: A Review on Its Characteristics, Antioxidant Potential, Gastrointestinal Microbiota Intervention, Anticancer Therapeutic and Mechanisms, Toxicity, and Encapsulation

Amygdalin protects against acetaminophen-induced acute liver failure by reducing inflammatory response and inhibiting hepatocyte death

(2022) Congcong Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Amygdalin potentiates the anti-cancer effect of Sorafenib on Ehrlich ascites carcinoma and ameliorates the associated liver damage

(2022) Attia Ahmed Attia et al.   Scientific Reports

In Vivo Growth Inhibition of Human Caucasian Prostate Adenocarcinoma in Nude Mice Induced by Amygdalin with Metabolic Enzyme Combinations

(2022) Ahmed Mohammed Alwan et al.   Biomed Research International

Amygdalin Exerts Antitumor Activity in Taxane-Resistant Prostate Cancer Cells

(2022) Igor Tsaur et al.   Cancers

Role of Amygdalin in Blocking DNA Replication in Breast Cancer In Vitro

(2021) Sarah Albogami et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The Combination of Amygdalin with Some Anticancer, Antiparasitic, and Antigout Drugs Against MG63, Saos2, SW1353, and FL Cells In Vitro

(2021) Davut Aydın et al.   JOURNAL OF MEDICINAL FOOD

Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds

(2021) Ewa Jaszczak-Wilke et al.   MOLECULES

Amygdalin Attenuates Airway Epithelium Apoptosis, Inflammation, and Epithelial-Mesenchymal Transition through Restraining the TLR4/NF-κB Signaling Pathway on LPS-Treated BEAS-2B Bronchial Epithelial Cells

(2021) Zhenyang Si et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Amygdalin Ameliorates Liver Fibrosis through Inhibiting Activation of TGF-β/Smad Signaling

(2021) Zhun Xiao et al.   Chinese Journal of Integrative Medicine

Anticancer effect of Amygdalin (vitamin B17) on hepatocellular carcinoma cell line(HepG2) in the presence and absence of Zinc.

(2020) Mohamed A. El-Desouky et al.   Anti-Cancer Agents in Medicinal Chemistry

Amygdalin as multi-target anticancer drug against targets of cell division cycle: double docking and molecular dynamics simulation

(2020) Khattab Al-Khafaji et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Amygdalin - A pharmacological and toxicological review

(2020) Xiao-Yan He et al.   JOURNAL OF ETHNOPHARMACOLOGY

Evaluation of the effective dose of amygdalin for the improvement of antioxidant gene expression and suppression of oxidative damage in mice

(2020) Sarah Albogami et al.   PeerJ

Prunus Armeniaca L. Seed Extract and Its Amygdalin Containing Fraction Induced Mitochondrial-Mediated Apoptosis and Autophagy in Liver Carcinogenesis

(2020) Samar Hosny et al.   Anti-Cancer Agents in Medicinal Chemistry

External and Genetic Conditions Determining Male Infertility

(2020) Piotr Kamiński et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Magnetically Directed Enzyme/Prodrug Prostate Cancer Therapy Based on β-Glucosidase/Amygdalin

(2020) Jie Zhou et al.   International Journal of Nanomedicine

Amygdalin decreases adhesion and migration of MDA-MB-231 and MCF-7 breast cancer cell lines

(2020) Bashir Mosayyebi et al.   Current Molecular Pharmacology

Molecular dynamics simulation, free energy landscape and binding free energy computations in exploration the anti-invasive activity of amygdalin against metastasis

(2020) Khattab Al-Khafaji et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Genotoxic and antigenotoxic potential of amygdalin on isolated human lymphocytes by the comet assay

(2020) Esra Erikel et al.   JOURNAL OF FOOD BIOCHEMISTRY

In silico authentication of amygdalin as a potent anticancer compound in the bitter kernels of family Rosaceae

(2020) Zainab Ayaz et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Amygdalin Promotes Fracture Healing through TGF-β/Smad Signaling in Mesenchymal Stem Cells

(2020) Jun Ying et al.   Stem Cells International

Amygdalin inhibits TGFβ1-induced activation of hepatic stellate cells (HSCs) in vitro and CCl4-induced hepatic fibrosis in rats in vivo

(2020) Ruoyu Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ergosterol Ameliorates Diabetic Nephropathy by Attenuating Mesangial Cell Proliferation and Extracellular Matrix Deposition via the TGF-β1/Smad2 Signaling Pathway

(2019) Zhonghua Dong et al.   Nutrients

Cyanide and lactate levels in patients during chronic oral amygdalin intake followed by intravenous amygdalin administration

(2019) Jens Mani et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review

(2019) Jiamin Shi et al.   Cancer Medicine

Amygdalin Modulates Prostate Cancer Cell Adhesion and Migration In Vitro

(2019) Jens Mani et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

In vitro and in silico anticancer activity of amygdalin on the SK-BR-3 human breast cancer cell line

(2019) Bahman Moradipoodeh et al.   MOLECULAR BIOLOGY REPORTS

Hepatoprotective and anti-inflammatory effects of total flavonoids of Qu Zhi Ke (peel of Citrus changshan-huyou) on non-alcoholic fatty liver disease in rats via modulation of NF-κB and MAPKs

(2019) Jianping Jiang et al.   PHYTOMEDICINE

Apoptosis Induction of Fibroblast-Like Synoviocytes Is an Important Molecular-Mechanism for Herbal Medicine along with its Active Components in Treating Rheumatoid Arthritis

(2019) Qing Zhang et al.   Biomolecules

Challenges in the diagnosis of acute cyanide poisoning

(2018) J. L. Parker-Cote et al.   CLINICAL TOXICOLOGY

Molecular mechanism of amygdalin action in vitro: review of the latest research

(2018) Przemysław Liczbiński et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Amygdalin improves microcirculatory disturbance and attenuates pancreatic fibrosis by regulating the expression of endothelin-1 and calcitonin gene-related peptide in rats

(2018) Xiangqun Zhang et al.   Journal of the Chinese Medical Association

Toxicity and Toxicokinetics of Amygdalin in Maesil (Prunus mume) Syrup: Protective Effect of Maesil against Amygdalin Toxicity

(2018) Mi-Ran Go et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antitumor Action of Amygdalin on Human Breast Cancer Cells by Selective Sensitization to Oxidative Stress

(2018) Muayad Mehdi Abboud et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Protective Effect of Amygdalin on LPS-Induced Acute Lung Injury by Inhibiting NF-κB and NLRP3 Signaling Pathways

(2017) Ao Zhang et al.   INFLAMMATION

Amygdalin ameliorates the progression of atherosclerosis in LDL receptor-deficient mice

(2017) Jianzhen Lv et al.   Molecular Medicine Reports

Effect of Amygdalin on the treatment and recurrence of endometriosis in an experimental rat study

(2017) Hatice Yilmaz Dogru   PERIODICUM BIOLOGORUM

Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells

(2016) Hye Min Lee et al.   Biomolecules & Therapeutics

Structural Change in Microbiota by a Probiotic Cocktail Enhances the Gut Barrier and Reduces Cancer via TLR2 Signaling in a Rat Model of Colon Cancer

(2016) Eugene Dogkotenge Kuugbee et al.   DIGESTIVE DISEASES AND SCIENCES

β-d-Glucosidase as “key enzyme” for sorghum cyanogenic glucoside (dhurrin) removal and beer bioflavouring

(2016) Sedjro Emile Tokpohozin et al.   FOOD AND CHEMICAL TOXICOLOGY

Aptamers Against Pro- and Anti-Inflammatory Cytokines: A Review

(2016) Maryam Boshtam et al.   INFLAMMATION

Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro

(2016) Jasmina Makarević et al.   LIFE SCIENCES

Amygdalin inhibits HSC-T6 cell proliferation and fibrosis through the regulation of TGF-β/CTGF

(2016) Huanhuan Luo et al.   Molecular & Cellular Toxicology

Amygdalin, quackery or cure?

(2016) Roman A. Blaheta et al.   PHYTOMEDICINE

Inhibition of cell growth and down-regulation of telomerase activity by amygdalin in human cancer cell lines

(2015) Ji-Yoon Moon et al.   Animal Cells and Systems

Mechanisms of the effects of probiotics on symbiotic digestion

(2015) N. A. Ushakova et al.   BIOLOGY BULLETIN

Chinese Medicine Amygdalin and β-Glucosidase Combined with Antibody Enzymatic Prodrug System As A Feasible Antitumor Therapy

(2015) Yun-long Li et al.   Chinese Journal of Integrative Medicine

Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review

(2015) Aleksandra Duda-Chodak et al.   EUROPEAN JOURNAL OF NUTRITION

Assessment of a potential preventive ability of amygdalin in mycotoxin-induced ovarian toxicity

(2015) Marek Halenar et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES

Proteomic identification of calcium-binding chaperone calreticulin as a potential mediator for the neuroprotective and neuritogenic activities of fruit-derived glycoside amygdalin

(2015) Yuanyuan Cheng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Antioxidant and angiotensin I converting enzyme (ACE) inhibitory activities of date seed protein hydrolysates prepared using Alcalase, Flavourzyme and Thermolysin

(2015) Priyatharini Ambigaipalan et al.   Journal of Functional Foods

Pre-systemic metabolism of orally administered drugs and strategies to overcome it

(2014) Irene Pereira de Sousa et al.   JOURNAL OF CONTROLLED RELEASE

A sensitive LC–MS/MS method for simultaneous determination of amygdalin and paeoniflorin in human plasma and its application

(2014) Xiaobing Li et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Phylogenetic and Functional Analysis of Gut Microbiota of a Fungus-Growing Higher Termite: Bacteroidetes from Higher Termites Are a Rich Source of β-Glucosidase Genes

(2014) Meiling Zhang et al.   MICROBIAL ECOLOGY

Amygdalin Blocks Bladder Cancer Cell Growth In Vitro by Diminishing Cyclin A and cdk2

(2014) Jasmina Makarević et al.   PLoS One

Amygdalin Influences Bladder Cancer Cell Adhesion and Invasion In Vitro

(2014) Jasmina Makarević et al.   PLoS One

Bioactivity-Guided Fractionation Identifies Amygdalin as a Potent Neurotrophic Agent from Herbal MedicineSemen PersicaeExtract

(2014) Chuanbin Yang et al.   Biomed Research International

Antioxidant, anticancer and hepatoprotective activities of Cotoneaster horizontalis Decne extract as well as α-tocopherol and amygdalin production from in vitro culture

(2013) Nadia Sokkar et al.   ACTA PHYSIOLOGIAE PLANTARUM

Proteomic Identification of Syzygium cumini Seed Extracts by MALDI-TOF/MS

(2013) Kumari Binita et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Polysaccharides utilization in human gut bacterium Bacteroides thetaiotaomicron: comparative genomics reconstruction of metabolic and regulatory networks

(2013) Dmitry A Ravcheev et al.   BMC GENOMICS

Gastrointestinal cancers: Influence of gut microbiota, probiotics and prebiotics

(2013) Daniela Elena Serban   CANCER LETTERS

Effect of different drying techniques on flowability characteristics and chemical properties of natural carbohydrate-protein Gum from durian fruit seed

(2013) Hamed Mirhosseini et al.   Chemistry Central Journal

Amygdalin content of seeds, kernels and food products commercially-available in the UK

(2013) Islamiyat F. Bolarinwa et al.   FOOD CHEMISTRY

Determination and Pharmacokinetics of Amygdalin in Rats by LC-MS-MS

(2013) X.-b. Li et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Amygdalin inhibits renal fibrosis in chronic kidney disease

(2013) JUNQI GUO et al.   Molecular Medicine Reports

A potential role of probiotics in colorectal cancer prevention: review of possible mechanisms of action

(2013) Esther Swee Lan Chong   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Enhancement of amygdalin activated with β-d-glucosidase on HepG2 cells proliferation and apoptosis

(2012) Cunshan Zhou et al.   CARBOHYDRATE POLYMERS

Amygdalin induces apoptosis in human cervical cancer cell line HeLa cells

(2012) Yu Chen et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Anti-Atherosclerotic Effects Mediated by the Combination of Probucol and Amygdalin in Apolipoprotein E-Knockout Mice Fed with a High Fat Diet

(2012) Deng Jiagang et al.   Journal of Animal and Veterinary Advances

Cyanide and Amygdalin as Indicators of the Presence of Bitter Almonds in Imported Raw Almonds

(2012) Valerie M. Toomey et al.   JOURNAL OF FORENSIC SCIENCES

Proline-Rich Tyrosine Kinase 2 (Pyk2) Regulates IGF-I-Induced Cell Motility and Invasion of Urothelial Carcinoma Cells

(2012) Marco Genua et al.   PLoS One

Evaluation of the Correlation between Focal Adhesion Kinase Phosphorylation and Cell Adhesion Force Using “DEP” Technology

(2012) Chyung Ay et al.   SENSORS

Role of intestinal microbiota in colon cancer prevention

(2011) Loredana Baffoni et al.   ANNALS OF MICROBIOLOGY

A Closer Look at Bacteroides: Phylogenetic Relationship and Genomic Implications of a Life in the Human Gut

(2011) Fredrik H. Karlsson et al.   MICROBIAL ECOLOGY

Catalytic degradation of amygdalin by extracellular enzymes from Aspergillus niger

(2011) Jun Chang et al.   PROCESS BIOCHEMISTRY

Cyanide poisoning caused by ingestion of apricot seeds

(2010) B. N. Akyildiz et al.   ANNALS OF TROPICAL PAEDIATRICS

2-(3-Methoxyphenyl)-6, 7-methylenedioxoquinolin-4-one, a novel synthetic compound, inhibited migration and invasion in TSGH8301 human bladder cancer cells

(2010) Kuang-Chi Lai et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Drug delivery and nanoparticles: Applications and hazards

(2010) de Jong   International Journal of Nanomedicine

Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects

(2010) Sebastian J. Padayatty et al.   PLoS One

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

(2009) Tim P. Green et al.   Molecular Oncology

Polysaccharides-based nanoparticles as drug delivery systems

(2008) Zonghua Liu et al.   ADVANCED DRUG DELIVERY REVIEWS