Article
Immunology
Qiao Zhou, Ding-Xiu He, Yi-Ling Deng, Chun-Li Wang, Lan-Lan Zhang, Fa-Ming Jiang, Laurent Irakoze, Zong-An Liang
Summary: This study found that miR-124-3p has a protective effect on acute lung injury (ALI) by inhibiting the TLR4/NF-kappa B signaling pathway, and miR-124-3p directly targets PDE4B to suppress this signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Dong Zhen, Tian-qi Xuan, Boqin Hu, Xue Bai, Dan-ni Fu, Yu Wang, Yun Wu, Jingfeng Yang, Qianqian Ma
Summary: Pteryxin has anti-inflammatory properties by inhibiting NF-kappa B/MAPK signaling pathway and blocking NLRP3 activation, suggesting it as a potential treatment option for inflammatory-related diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Qiudong Yang, Wenhua Zhao, Yuyi Chen, Yue Chen, Jiali Shi, Ran Qin, Hua Wang, Ruixia Wang, Hua Yuan, Wen Sun
Summary: The study reveals that the RelA/miR-30a/NLRP3 signaling axis is involved in rheumatoid arthritis by regulating the NLRP3 inflammasome in macrophages.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Wei Gao, Ying Zhang
Summary: Inflammation is crucial in the pathogenesis of acute lung injury, and lncRNA MINCR may exacerbate ALI/ARDS progression by inducing alveolar epithelial cell injury and inflammation through the miR-146b-5p and TRAF6/NF-κB pathways, serving as a potential therapeutic target.
MOLECULAR MEDICINE
(2021)
Article
Immunology
Xiaofang Lv, Chun Fan, Zhongxin Jiang, Wenxuan Wang, Xu Qiu, Qiuxia Ji
Summary: Porphyromonas gingivalis-LPS/ATP stimulation significantly increased the expression of NF-kappa B, the NLRP3 inflammasome, GSDMD, and IL-1β at gene and protein levels, as well as membrane damage, caspase-1 activity, and LDH release. However, pretreatment with ISL noticeably suppressed these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Man Liu, Ying-Lin Yang, Shan-Shan Zhang, Dong-Ni Liu, Lian-Hua Fang, Guan-Hua Du, Yue-Hua Wang
Summary: The study revealed that RKC-B1 exhibits anti-neuroinflammatory effects in LPS-stimulated mice by modulating multiple inflammatory signaling pathways, suggesting it could be a promising agent for treating neuroinflammation.
Article
Plant Sciences
Tian-qi Xuan, Guohua Gong, Huanhuan Du, Chunyan Liu, Yun Wu, Guilan Bao, Qianqian Ma, Dong Zhen
Summary: This study aimed to investigate the potential of pteryxin in alleviating LPS-induced lung injury and explore the underlying mechanism. The results indicated that pteryxin effectively reduced the severity of lung injury by suppressing the MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Jie Yang, Jiawen Yang, Xiaofang Huang, Huiqing Xiu, Songjie Bai, Jiahui Li, Zhijian Cai, Zhanghui Chen, Shufang Zhang, Gensheng Zhang
Summary: Glibenclamide alleviates the development of LPS-induced acute lung injury in a mouse model by inhibiting the NLRP3/Caspase-1/IL-1β signaling pathway.
MEDIATORS OF INFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Siqi Tang, Chunying Li, Zongwu Suo, Yi Xu, Kaixin Wei, Lei Zhao, Hao Huang, Xiangqian Liu, Dongxu Liu, Xiaojun Li
Summary: According to traditional Chinese medicine theory, the traditional herb Eleutherococcus henryi Oliv. is commonly used to treat inflammatory conditions. This study aimed to determine whether the natural lignan savinin obtained from the roots of E. henryi can relieve LPS-induced neuroinflammation and the underlying mechanism. The results showed that savinin significantly decreased the levels of neuroinflammatory cytokines and improved the LPS-induced neuroinflammatory response in mice by modulating the MAPK/NF-kappa B and NLRP3 signaling pathways.
Article
Immunology
Shun Tang, Yuanjing Liang, Minmin Wang, Jiarong Lei, Yuhui Peng, Qiu Tao, Tianqi Ming, Wenyu Yang, Chuantao Zhang, Jinlin Guo, Haibo Xu
Summary: Acute lung injury (ALI) is a common condition associated with the activation of the TLR4/NF-kappa B signaling pathway and NLRP3 inflammasome. Qinhuo Shanggan oral solution (QHSG) shows anti-inflammatory effects and improves ALI by modulating these pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Jianjian Dong, Xun Wang, Chenchen Xu, Manli Gao, Shijing Wang, Jin Zhang, Haiyang Tong, Lulu Wang, Yongzhu Han, Nan Cheng, Yongsheng Han
Summary: The study demonstrates that copper-mediated neuroinflammation is associated with the activation of the NLRP3 inflammasome, contributing to progressive neuropathology in a murine model of WD. Blocking the activation of the NLRP3 inflammasome effectively mitigates cognitive decline, locomotor behavior impairment, and neurodegeneration in the mice.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Taha Yazal, Po-Yen Lee, Pin-Rong Chen, I-Chen Chen, Po-Len Liu, Yuan-Ru Chen, Tzu-Chieh Lin, Yi-Ting Chen, Shu-Pin Huang, Hsin-Chih Yeh, Ching-Chih Liu, Jung Lo, Hsin-En Wu, Shu-Chi Wang, Chia-Yang Li
Summary: This study demonstrated that kurarinone exerts anti-inflammatory effects and protects against LPS-induced sepsis damage by inhibiting MAPK/NF-kappa B pathways, attenuating NLRP3 inflammasome formation, and preventing intracellular ROS accumulation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Min Zhang, Juan Zhang, Qi-Meng Zhu, Wen-Yu Zhao, Xia Lv, Jing Yi, Xiao-Kui Huo, Mi-Jia Wang, Cheng-Peng Sun
Summary: This study investigates the protective effect and underlying mechanism of Inula japonica (TEIJ) in the treatment of acute lung injury (ALI). It is found that TEIJ can alleviate ALI by suppressing inflammation and oxidative stress through regulating the MAPK/NF-kappa B and Keap1/Nrf2 signaling pathways.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Shumeng Lin, Jing Wen, Xiao Xu, Jiamin Shi, Wen Zhang, Tiansheng Zheng, Yaqin Hou, Yanfei Zhang, Ziye Li, Kai Wang, Jing Jin, Liduo Yue, Baigenzhin Abay, Ming Li, Qingxi Yue, Lihong Fan
Summary: Amygdalin induces apoptosis of lung cancer cells through multiple mechanisms, including altered expression of apoptosis-related proteins, activation of NF kappa B-1 gene, and inhibition of NF kappa B signaling cascade. These findings reveal the potential of amygdalin as a therapeutic agent for lung cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Chemistry, Medicinal
Shan Han, Siyuan Li, Jilang Li, Jia He, Qin-Qin Wang, Xiang Gao, Shilin Yang, Jingjing Li, Renyikun Yuan, Guoyue Zhong, Hongwei Gao
Summary: Acute kidney injury (AKI) is a common clinical condition with high incidence and mortality rates. This study found that Hederasaponin C (HSC) has a protective effect against lipopolysaccharide (LPS)-induced renal inflammation by inhibiting the expression of TLR4 and the activation of NF-kappa B and PIP2 signaling pathways, as well as suppressing the activation of the NLRP3 inflammasome.
PHYTOTHERAPY RESEARCH
(2023)