Compressive stress drives adhesion-dependent unjamming transitions in breast cancer cell migration

Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex

(2022) Jing Wang et al.   Cell Reports

Compression enhances invasive phenotype and matrix degradation of breast cancer cells via Piezo1 activation

(2022) Mingzhi Luo et al.   BMC Molecular and Cell Biology

Mechanosensitive calcium flashes promote sustained RhoA activation during tight junction remodeling

(2022) Saranyaraajan Varadarajan et al.   JOURNAL OF CELL BIOLOGY

Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers

(2021) Lakshmi Balasubramaniam et al.   NATURE MATERIALS

Cell and Nucleus Shape as an Indicator of Tissue Fluidity in Carcinoma

(2021) Steffen Grosser et al.   Physical Review X

Tumor cell nuclei soften during transendothelial migration

(2021) Anya B. Roberts et al.   JOURNAL OF BIOMECHANICS

Molecular cancer cell responses to solid compressive stress and interstitial fluid pressure

(2021) Purboja Purkayastha et al.   Cytoskeleton

Jamming in Embryogenesis and Cancer Progression

(2021) Eliane Blauth et al.   Frontiers in Physics

Jamming and arrest of cell motion in biological tissues

(2021) Elizabeth Lawson-Keister et al.   CURRENT OPINION IN CELL BIOLOGY

Tractions and Stress Fibers Control Cell Shape and Rearrangements in Collective Cell Migration

(2020) Aashrith Saraswathibhatla et al.   Physical Review X

Effect of Nuclear Stiffness on Cell Mechanics and Migration of Human Breast Cancer Cells

(2020) Tony Fischer et al.   Frontiers in Cell and Developmental Biology

Nesprins are mechanotransducers that discriminate epithelial–mesenchymal transition programs

(2020) Théophile Déjardin et al.   JOURNAL OF CELL BIOLOGY

Mechanical strain induces phenotypic changes in breast cancer cells and promotes immunosuppression in the tumor microenvironment

(2020) Yong Wang et al.   LABORATORY INVESTIGATION

Direct evidence that tumor cells soften when navigating confined spaces

(2020) Carmela Rianna et al.   MOLECULAR BIOLOGY OF THE CELL

Multi-Omics Characterization of the 4T1 Murine Mammary Gland Tumor Model

(2020) Barbara Schrörs et al.   Frontiers in Oncology

Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

(2020) Olga Ilina et al.   NATURE CELL BIOLOGY

In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition

(2020) Jennifer A. Mitchel et al.   Nature Communications

Cell Shape and Durotaxis Explained from Cell-Extracellular Matrix Forces and Focal Adhesion Dynamics

(2020) Elisabeth G. Rens et al.   iScience

Mechanical Adaptability of Tumor Cells in Metastasis

(2020) Valentin Gensbittel et al.   DEVELOPMENTAL CELL

Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells

(2020) Jonathon M. Muncie et al.   DEVELOPMENTAL CELL

Cancer cells in the tumor core exhibit spatially coordinated migration patterns

(2019) Ralitza Staneva et al.   JOURNAL OF CELL SCIENCE

Wound healing coordinates actin architectures to regulate mechanical work

(2019) Visar Ajeti et al.   Nature Physics

Physical Models of Collective Cell Migration

(2019) Ricard Alert et al.   Annual Review of Condensed Matter Physics

Tensile Forces and Mechanotransduction at Cell–Cell Junctions

(2018) Guillaume Charras et al.   CURRENT BIOLOGY

Mesoscale physical principles of collective cell organization

(2018) Xavier Trepat et al.   Nature Physics

Geometric constraints during epithelial jamming

(2018) Lior Atia et al.   Nature Physics

E-cadherin in contact inhibition and cancer

(2018) Alisha M. Mendonsa et al.   ONCOGENE

Non-intrusive measurement of wall shear stress in flow channels

(2018) Yashar Bashirzadeh et al.   SENSORS AND ACTUATORS A-PHYSICAL

From jamming to collective cell migration through a boundary induced transition

(2018) Oleksandr Chepizhko et al.   Soft Matter

Stiffness Measurement of Soft Silicone Substrates for Mechanobiology Studies Using a Widefield Fluorescence Microscope

(2018) Yashar Bashirzadeh et al.   Jove-Journal of Visualized Experiments

Mechanical Response of an Epithelial Island Subject to Uniaxial Stretch on a Hybrid Silicone Substrate

(2018) Yashar Bashirzadeh et al.   Cellular and Molecular Bioengineering

Mechanical Force-Driven Adherens Junction Remodeling and Epithelial Dynamics

(2018) Diana Pinheiro et al.   DEVELOPMENTAL CELL

Membrane mechanics govern spatiotemporal heterogeneity of endocytic clathrin coat dynamics

(2017) N. M. Willy et al.   MOLECULAR BIOLOGY OF THE CELL

EMT and MET: necessary or permissive for metastasis?

(2017) Mohit Kumar Jolly et al.   Molecular Oncology

Endocytic reawakening of motility in jammed epithelia

(2017) Chiara Malinverno et al.   NATURE MATERIALS

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Motility-Driven Glass and Jamming Transitions in Biological Tissues

(2016) Dapeng Bi et al.   Physical Review X

Cell spreading area regulates clathrin-coated pit dynamics on micropatterned substrate

(2015) Xinyu Tan et al.   Integrative Biology

A microfluidic pipette array for mechanophenotyping of cancer cells and mechanical gating of mechanosensitive channels

(2015) Lap Man Lee et al.   LAB ON A CHIP

Unjamming and cell shape in the asthmatic airway epithelium

(2015) Jin-Ah Park et al.   NATURE MATERIALS

A density-independent rigidity transition in biological tissues

(2015) Dapeng Bi et al.   Nature Physics

Physics of active jamming during collective cellular motion in a monolayer

(2015) Simon Garcia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Cell jamming: Collective invasion of mesenchymal tumor cells imposed by tissue confinement

(2014) Anna Haeger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Energy barriers and cell migration in densely packed tissues

(2014) Dapeng Bi et al.   Soft Matter

Automated velocity mapping of migrating cell populations (AVeMap)

(2012) Maxime Deforet et al.   NATURE METHODS

The impact of jamming on boundaries of collectively moving weak-interacting cells

(2012) Kenechukwu David Nnetu et al.   NEW JOURNAL OF PHYSICS

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

(2012) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear mechanics during cell migration

(2010) Peter Friedl et al.   CURRENT OPINION IN CELL BIOLOGY

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

miR-200 Enhances Mouse Breast Cancer Cell Colonization to Form Distant Metastases

(2009) Derek M. Dykxhoorn et al.   PLoS One

Imagable 4T1 model for the study of late stage breast cancer

(2008) Kai Tao et al.   BMC CANCER

High Resolution Traction Force Microscopy Based on Experimental and Computational Advances

(2007) Benedikt Sabass et al.   BIOPHYSICAL JOURNAL