The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
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Title
The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
Authors
Keywords
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Journal
Frontiers in Oncology
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-10-12
DOI
10.3389/fonc.2022.985363
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Note: Only part of the references are listed.- Small Drugs, Huge Impact: The Extraordinary Impact of Antisense Oligonucleotides in Research and Drug Development
- (2022) Anais M. Quemener et al. MOLECULES
- The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner
- (2022) Anna-Lena Meinhardt et al. ONCOGENE
- Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro
- (2022) Binli Mao et al. Emerging Microbes & Infections
- BH3-Only Proteins Noxa and Puma Are Key Regulators of Induced Apoptosis
- (2022) Rabih Roufayel et al. Life-Basel
- Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells
- (2022) Xuexin Feng et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Infectious Spleen and Kidney Necrosis Virus (ISKNV) Triggers Mitochondria-Mediated Dynamic Interaction Signals via an Imbalance of Bax/Bak over Bcl-2/Bcl-xL in Fish Cells
- (2022) Pin-Han Chen et al. Viruses-Basel
- Bax/Bcl-2 Cascade Is Regulated by the EGFR Pathway: Therapeutic Targeting of Non-Small Cell Lung Cancer
- (2022) Manzar Alam et al. Frontiers in Oncology
- Stepwise activation of the pro-apoptotic protein Bid at mitochondrial membranes
- (2021) Chien-Lun Hung et al. CELL DEATH AND DIFFERENTIATION
- Mitochondrial outer membrane permeabilization at the single molecule level
- (2021) Shashank Dadsena et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases
- (2021) Mei Li APOPTOSIS
- Structural basis of the p53 DNA binding domain and PUMA complex
- (2021) Chang Woo Han et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The cell theory and cellular pathology: Discovery, refinements and applications fundamental to advances in biology and medicine
- (2021) L. Maximilian Buja EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Redox metabolism: ROS as specific molecular regulators of cell signaling and function
- (2021) Claudia Lennicke et al. MOLECULAR CELL
- Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk
- (2021) Chathura D. Suraweera et al. Viruses-Basel
- The role of Ubiquitination in Apoptosis and Necroptosis
- (2021) Jamie Z. Roberts et al. CELL DEATH AND DIFFERENTIATION
- B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer Therapy
- (2021) Manzar Alam et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The bioinformatics analysis of RIOX2 gene in lung adenocarcinoma and squamous cell carcinoma
- (2021) Bingqing Sun et al. PLoS One
- Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer (Review)
- (2021) Yulou Luo et al. Oncology Letters
- Designing BH3-Mimetic Peptide Inhibitors for the Viral Bcl-2 Homologues A179L and BHRF1: Importance of Long-Range Electrostatic Interactions
- (2021) Chinthakunta Narendra Reddy et al. ACS Omega
- BH3-only proteins Puma and Beclin1 regulate autophagic death in neurons in response to Amyloid-β
- (2021) Akash Saha et al. Cell Death Discovery
- A novel Bcl-2 inhibitor, BM-1197, induces apoptosis in malignant lymphoma cells through the endogenous apoptotic pathway
- (2020) Yue-Li Sun et al. BMC CANCER
- miR‐125b lowers sensitivity to apoptosis following mitotic arrest: Implications for breast cancer therapy
- (2020) Janusz Matuszyk et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The apoptosis inhibitor Bcl-xL controls breast cancer cell migration through mitochondria-dependent reactive oxygen species production
- (2020) Margaux Bessou et al. ONCOGENE
- MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21Cip1
- (2020) Anna Huo-Chang Mei et al. Oncotarget
- Akkermansia muciniphila Aspartic Protease Amuc_1434* Inhibits Human Colorectal Cancer LS174T Cell Viability via TRAIL-Mediated Apoptosis Pathway
- (2020) Xin Meng et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The pan-Bcl-2 inhibitor obatoclax promotes differentiation and apoptosis of acute myeloid leukemia cells
- (2020) Małgorzata Opydo-Chanek et al. INVESTIGATIONAL NEW DRUGS
- Identifying Lung Cancer Risk Factors in the Elderly Using Deep Neural Networks: Quantitative Analysis of Web-Based Survey Data
- (2020) Songjing Chen et al. JOURNAL OF MEDICAL INTERNET RESEARCH
- Targeting apoptosis in cancer therapy
- (2020) Benedito A. Carneiro et al. Nature Reviews Clinical Oncology
- BCL-w: apoptotic and non-apoptotic role in health and disease
- (2020) Mariusz L. Hartman et al. Cell Death & Disease
- Kaempferol protects mitochondria and alleviates damages against endotheliotoxicity induced by doxorubicin
- (2020) Weiqi Wu et al. BIOMEDICINE & PHARMACOTHERAPY
- Selective Covalent Targeting of Anti‐Apoptotic BFL‐1 by a Sulfonium Tethered Peptide
- (2020) Na Liu et al. CHEMBIOCHEM
- Myeloid cell leukemin-1 inhibitors: a growing arsenal for cancer therapy
- (2020) Peng-Ju Zhu et al. DRUG DISCOVERY TODAY
- Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization
- (2020) Zachary J. Hauseman et al. MOLECULAR CELL
- Prognostic value of circulating Bcl-2 and anti-p53 antibodies in patients with breast cancer: A long term follow-up (17.5 years)
- (2020) Maja Sirotković-Skerlev et al. Cancer Biomarkers
- Phosphorylation by Aurora B kinase regulates caspase-2 activity and function
- (2020) Yoon Lim et al. CELL DEATH AND DIFFERENTIATION
- TMPRSS13 promotes cell survival, invasion, and resistance to drug-induced apoptosis in colorectal cancer
- (2020) Fausto A. Varela et al. Scientific Reports
- Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells
- (2020) Hyun-Young Lee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cell death signalling in virus infection
- (2020) Gergely Imre CELLULAR SIGNALLING
- The Mysteries around the BCL-2 Family Member BOK
- (2020) Raed Shalaby et al. Biomolecules
- Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
- (2019) Rumani Singh et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Targeting the Bcl-2 Family in B Cell Lymphoma
- (2019) Clare M. Adams et al. Frontiers in Oncology
- Bok regulates mitochondrial fusion and morphology
- (2019) Jacqualyn J. Schulman et al. CELL DEATH AND DIFFERENTIATION
- The Structural Biology of Bcl-xL
- (2019) Erinna F. Lee et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2
- (2019) Qian Liu et al. eLife
- The novel non-immunological role and underlying mechanisms of B7-H3 in tumorigenesis
- (2019) Xiangqi Zhou et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The chemical biology of apoptosis: Revisited after 17 years
- (2019) Shu Yang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Beclin 1 promotes endosome recruitment of hepatocyte growth factor tyrosine kinase substrate (HRS) to suppress tumor proliferation
- (2019) Asia N Matthew-Onabanjo et al. CANCER RESEARCH
- Exploring the Conformational Space of Bcl-2 Protein Variants: Dynamic Contributions of the Flexible Loop Domain and Transmembrane Region
- (2019) Luis A. Caro-Gómez et al. MOLECULES
- Expression of the BAD pathway is a marker of triple-negative status and poor outcome
- (2019) Bernadette M. Boac et al. Scientific Reports
- RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death
- (2019) Zhi Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- BCL-2 family proteins in apoptosis and its regulation
- (2019) Chen Zheng et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Tumour evolution in hepatocellular carcinoma
- (2019) Amanda J. Craig et al. Nature Reviews Gastroenterology & Hepatology
- BCL-2 proteins and apoptosis: Recent insights and unknowns
- (2018) Frank Edlich BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The rise of apoptosis: targeting apoptosis in hematologic malignancies
- (2018) Rebecca Valentin et al. BLOOD
- Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight
- (2018) K. Lohitesh et al. Cancer Cell International
- DNA damage pathways and B-cell lymphomagenesis
- (2018) Gero Knittel et al. CURRENT OPINION IN HEMATOLOGY
- Mitochondrial dynamics: overview of molecular mechanisms
- (2018) Lisa Tilokani et al. Essays in Biochemistry
- Hide or defend, the two strategies of lymphoma immune evasion: potential implications for immunotherapy.
- (2018) Marie de Charette et al. HAEMATOLOGICA
- Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis
- (2018) Young-Sun Lee et al. MOLECULAR CANCER RESEARCH
- Systematic characterization of pan‐cancer mutation clusters
- (2018) Marija Buljan et al. Molecular Systems Biology
- RACK1 induces chemotherapy resistance in esophageal carcinoma by upregulating the PI3K/AKT pathway and Bcl-2 expression
- (2018) Bowen Liu et al. OncoTargets and Therapy
- Bax retrotranslocation potentiates Bcl-xL’s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance
- (2018) Annika Hantusch et al. Cell Death & Disease
- The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer
- (2018) Steven Carberry et al. Cell Death & Disease
- Targeting BCL-2 regulated apoptosis in cancer
- (2018) Kirsteen J. Campbell et al. Open Biology
- Hide or defend, the two strategies of lymphoma immune evasion: potential implications for immunotherapy.
- (2018) Marie de Charette et al. HAEMATOLOGICA
- BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL
- (2018) Georgia Greaves et al. CELL DEATH AND DIFFERENTIATION
- miRNA-448 inhibits cell growth by targeting BCL-2 in hepatocellular carcinoma
- (2018) Zhi-bin Liao et al. DIGESTIVE AND LIVER DISEASE
- Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis
- (2018) Hasini A. Kalpage et al. FASEB JOURNAL
- Targeting Bcl-2 for the treatment of multiple myeloma
- (2018) Cyrille Touzeau et al. LEUKEMIA
- Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review
- (2018) Changmin Kim et al. Nutrients
- Balancing apoptosis and autophagy for Parkinson’s disease therapy: targeting BCL-2
- (2018) Jia Liu et al. ACS Chemical Neuroscience
- Bile salt (glycochenodeoxycholate acid) induces cell survival and chemoresistance in hepatocellular carcinoma
- (2018) Chengzhi Wang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Targeting Mcl-1 and other Bcl-2 family member proteins in cancer therapy
- (2018) Ryuji Yamaguchi et al. PHARMACOLOGY & THERAPEUTICS
- Acquisition of the recurrent Gly101Val mutation in BCL2 confers resistance to venetoclax in patients with progressive chronic lymphocytic leukemia
- (2018) Piers Blombery et al. Cancer Discovery
- Bax, Bak and beyond - mitochondrial performance in apoptosis
- (2017) Aida Peña-Blanco et al. FEBS Journal
- Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis
- (2017) Daniela Sia et al. GASTROENTEROLOGY
- Pathways and mechanisms of venetoclax resistance
- (2017) Prithviraj Bose et al. LEUKEMIA & LYMPHOMA
- The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane
- (2016) Mark P.A. Luna-Vargas et al. FEBS Journal
- The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update
- (2015) Waseem Ahmad Siddiqui et al. ARCHIVES OF TOXICOLOGY
- Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis
- (2015) Anna Fernández et al. JOURNAL OF PINEAL RESEARCH
- A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia
- (2015) Thomas J. Kipps et al. LEUKEMIA & LYMPHOMA
- Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer
- (2015) D Merino et al. ONCOGENE
- Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma
- (2014) V. Fresquet et al. BLOOD
- Crosstalk between apoptosis, necrosis and autophagy
- (2013) Vassiliki Nikoletopoulou et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Signatures of mutational processes in human cancer
- (2013) Ludmil B. Alexandrov et al. NATURE
- ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
- (2013) Andrew J Souers et al. NATURE MEDICINE
- Thioredoxin-interacting protein and myocardial mitochondrial function in ischemia–reperfusion injury
- (2013) Jun Yoshioka et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer
- (2012) Wiem Chaabane et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- Regulation of the Inflammatory Response in Cardiac Repair
- (2012) Nikolaos G. Frangogiannis CIRCULATION RESEARCH
- Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition
- (2012) Ismail Adam Arbab et al. Evidence-based Complementary and Alternative Medicine
- MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R
- (2012) J Gong et al. ONCOGENE
- The role of mitochondria in apoptosis
- (2011) Seon-Yong Jeong et al. BMB Reports
- The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy
- (2011) P N Kelly et al. CELL DEATH AND DIFFERENTIATION
- Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
- (2011) Haiming Dai et al. JOURNAL OF CELL BIOLOGY
- A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria
- (2011) Fabien Llambi et al. MOLECULAR CELL
- Molecular biology of Bax and Bak activation and action
- (2010) Dana Westphal et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis
- (2010) Craig M. Walsh et al. IMMUNOLOGICAL REVIEWS
- Bfl-1/A1 acts as a negative regulator of autophagy in mycobacteria infected macrophages
- (2010) Mahesh Kathania et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells
- (2009) Elif Damla Arisan et al. BREAST CANCER RESEARCH AND TREATMENT
- Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy
- (2009) M. H. Kang et al. CLINICAL CANCER RESEARCH
- Life and death by death receptors
- (2009) Maria Eugenia Guicciardi et al. FASEB JOURNAL
- Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells
- (2009) K. Simonin et al. MOLECULAR CANCER THERAPEUTICS
- The BCL-2 protein family: opposing activities that mediate cell death
- (2007) Richard J. Youle et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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