Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro

Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

(2021) Guido Papa et al.   PLoS Pathogens

The interplay between emerging human coronavirus infections and autophagy

(2021) Zhenyu Zhao et al.   Emerging Microbes & Infections

Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

(2021) Rita E. Chen et al.   NATURE MEDICINE

Berberine and Obatoclax Inhibit SARS-Cov-2 Replication in Primary Human Nasal Epithelial Cells In Vitro

(2021) Finny Varghese et al.   Viruses-Basel

Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant

(2021) Vivek Shinde et al.   NEW ENGLAND JOURNAL OF MEDICINE

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

(2021) Yabin Zhang et al.   Cell Discovery

Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study

(2021) Mark S Graham et al.   Lancet Public Health

Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination

(2021) Emma C Wall et al.   LANCET

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS‐CoV, MERS‐CoV, and 2019‐nCoV

(2020) Jia Liu et al.   JOURNAL OF MEDICAL VIROLOGY

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Author Correction: A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

(2020) Shutoku Matsuyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity

(2020) Gretchen Ehrenkaufer et al.   PLoS Neglected Tropical Diseases

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

(2020) Ruochen Zang et al.   Science Immunology

Coronavirus membrane fusion mechanism offers a potential target for antiviral development

(2020) Tiffany Tang et al.   ANTIVIRAL RESEARCH

Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2

(2020) Markus Hoffmann et al.   NATURE

Potential Antiviral Options against SARS-CoV-2 Infection

(2020) Aleksandr Ianevski et al.   Viruses-Basel

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

(2020) Dorothea Bestle et al.   Life Science Alliance

Molecular Architecture of the SARS-CoV-2 Virus

(2020) Hangping Yao et al.   CELL

The UCSC SARS-CoV-2 Genome Browser

(2020) Jason D. Fernandes et al.   NATURE GENETICS

Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects

(2020) Ya-Wen Cheng et al.   Cell Reports

Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors—The Current Status

(2020) Narasimha M. Beeraka et al.   Frontiers in Immunology

Progress and Pitfalls in the Quest for Effective SARS-CoV-2 (COVID-19) Vaccines

(2020) Katie L. Flanagan et al.   Frontiers in Immunology

A Novel In-Cell ELISA Assay Allows Rapid and Automated Quantification of SARS-CoV-2 to Analyze Neutralizing Antibodies and Antiviral Compounds

(2020) Lara Schöler et al.   Frontiers in Immunology

Furin: A Potential Therapeutic Target for COVID-19

(2020) Canrong Wu et al.   iScience

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection

(2020) Pranesh Padmanabhan et al.   PLoS Computational Biology

Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling

(2019) Yong Lin et al.   Autophagy

Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine

(2019) Andersen et al.   Viruses-Basel

Classics in Chemical Neuroscience: Chlorpromazine

(2018) Debra Boyd-Kimball et al.   ACS Chemical Neuroscience

The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR

(2018) Jo-Chi Kao et al.   PLoS Neglected Tropical Diseases

Infectious bronchitis virus entry mainly depends on clathrin mediated endocytosis and requires classical endosomal/lysosomal system

(2018) Huan Wang et al.   VIROLOGY

Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments

(2016) Finny S. Varghese et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ATP1A1-Mediated Src Signaling Inhibits Coronavirus Entry into Host Cells

(2015) Christine Burkard et al.   JOURNAL OF VIROLOGY

Obatoclax in combination with fludarabine and rituximab is well-tolerated and shows promising clinical activity in relapsed chronic lymphocytic leukemia

(2015) Jennifer R. Brown et al.   LEUKEMIA & LYMPHOMA

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

(2015) Jean Kaoru Millet et al.   VIRUS RESEARCH

Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner

(2014) Christine Burkard et al.   PLoS Pathogens

Suppression of Lysosome Function Induces Autophagy via a Feedback Down-regulation of MTOR Complex 1 (MTORC1) Activity

(2013) Min Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obatoclax Mesylate, a Pan–Bcl-2 Inhibitor, in Combination with Docetaxel in a Phase 1/2 Trial in Relapsed Non–Small-Cell Lung Cancer

(2013) Alberto Chiappori et al.   Journal of Thoracic Oncology

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Obatoclax, Saliphenylhalamide, and Gemcitabine Inhibit Influenza A Virus Infection

(2012) Oxana V. Denisova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the B-Cell Lymphoma/Leukemia 2 Family in Cancer

(2012) Matthew S. Davids et al.   JOURNAL OF CLINICAL ONCOLOGY

Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry

(2012) M. Kawase et al.   JOURNAL OF VIROLOGY

Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence

(2012) Taylor Heald-Sargent et al.   Viruses-Basel

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK

(2010) F McCoy et al.   Cell Death & Disease