Metabolic-imaging of human glioblastoma live tumors: A new precision-medicine approach to predict tumor treatment response early

BIRC3 and BIRC5: multi‐faceted inhibitors in cancer

(2021) Raffaele Frazzi   Cell and Bioscience

FLIM as a Promising Tool for Cancer Diagnosis and Treatment Monitoring

(2021) Yuzhen Ouyang et al.   Nano-Micro Letters

Functional precision oncology: Testing tumors with drugs to identify vulnerabilities and novel combinations

(2021) Anthony Letai et al.   CANCER CELL

Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion

(2021) Emilie Darrigues et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models

(2021) Max A. Stockslager et al.   Cell Reports

CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications

(2020) Sebastià Franch-Expósito et al.   eLife

Tumor mutational burden is associated with poor outcomes in diffuse glioma

(2020) Lihong Wang et al.   BMC CANCER

Fluorescence lifetime imaging microscopy: fundamentals and advances in instrumentation, analysis, and applications

(2020) Rupsa Datta et al.   JOURNAL OF BIOMEDICAL OPTICS

Discriminating different grades of cervical intraepithelial neoplasia based on label-free phasor fluorescence lifetime imaging microscopy

(2020) Xinyi Wang et al.   Biomedical Optics Express

Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment

(2020) Joe T. Sharick et al.   Frontiers in Oncology

Management of glioblastoma: State of the art and future directions

(2020) Aaron C. Tan et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

(2020) Anna Golebiewska et al.   ACTA NEUROPATHOLOGICA

Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy

(2020) Soniya Bastola et al.   Nature Communications

Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma

(2020) Zammam Areeb et al.   Scientific Reports

Current Opinion on Molecular Characterization for GBM Classification in Guiding Clinical Diagnosis, Prognosis, and Therapy

(2020) Pei Zhang et al.   Frontiers in Molecular Biosciences

Macroscopic fluorescence-lifetime imaging of NADH and protoporphyrin IX improves the detection and grading of 5-aminolevulinic acid-stained brain tumors

(2020) Mikael T. Erkkilä et al.   Scientific Reports

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

(2020) Bárbara Pinto et al.   Pharmaceutics

Challenges to curing primary brain tumours

(2019) Kenneth Aldape et al.   Nature Reviews Clinical Oncology

Total copy number variation as a prognostic factor in adult astrocytoma subtypes

(2019) Kanish Mirchia et al.   Acta Neuropathologica Communications

Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients

(2019) Josefine Radke et al.   Acta Neuropathologica Communications

Novel Function of lncRNA ADAMTS9-AS2 in Promoting Temozolomide Resistance in Glioblastoma via Upregulating the FUS/MDM2 Ubiquitination Axis

(2019) Yuanliang Yan et al.   Frontiers in Cell and Developmental Biology

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

(2019) Fadi Jacob et al.   CELL

Evaluating Cell Metabolism Through Autofluorescence Imaging of NAD(P)H and FAD

(2018) Olivia I. Kolenc et al.   ANTIOXIDANTS & REDOX SIGNALING

Metabolic cofactors NAD(P)H and FAD as potential indicators of cancer cell response to chemotherapy with paclitaxel

(2018) Maria M. Lukina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Association between SOX9 and CA9 in glioma, and its effects on chemosensitivity to TMZ

(2018) Xiaoshan Xu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Automated brightfield morphometry of 3D organoid populations by OrganoSeg

(2018) Michael A. Borten et al.   Scientific Reports

Fit-free analysis of fluorescence lifetime imaging data using the phasor approach

(2018) Suman Ranjit et al.   Nature Protocols

Vinblastine and antihelmintic mebendazole potentiate temozolomide in resistant gliomas

(2017) Franciele Cristina Kipper et al.   INVESTIGATIONAL NEW DRUGS

Tracking Functional Tumor Cell Subpopulations of Malignant Glioma by Phasor Fluorescence Lifetime Imaging Microscopy of NADH

(2017) Andrew Trinh et al.   Cancers

Drug response in organoids generated from frozen primary tumor tissues

(2016) Alex J. Walsh et al.   Scientific Reports

BIRC3 is a novel driver of therapeutic resistance in Glioblastoma

(2016) Dapeng Wang et al.   Scientific Reports

Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain

(2015) Christoph Geisenberger et al.   ACTA NEUROPATHOLOGICA

Somatic mutations in glioblastoma are associated with methylguanine-DNA methyltransferase methylation

(2015) KERRIE L. MCDONALD et al.   Oncology Letters

Long-term In Vitro Treatment of Human Glioblastoma Cells with Temozolomide Increases Resistance In Vivo through Up-regulation of GLUT Transporter and Aldo-Keto Reductase Enzyme AKR1C Expression

(2015) Benjamin Le Calvé et al.   NEOPLASIA

Quantitative Optical Imaging of Primary Tumor Organoid Metabolism Predicts Drug Response in Breast Cancer

(2014) A. J. Walsh et al.   CANCER RESEARCH

Animal models and therapeutic molecular targets of cancer: utility and limitations

(2014) Maria Cekanova et al.   Drug Design Development and Therapy

Glioma Malignancy-Dependent NDRG2 Gene Methylation and Downregulation Correlates with Poor Patient Outcome

(2014) Daina Skiriutė et al.   Journal of Cancer

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

(2013) Marthe H. R. Ludtmann et al.   BIOCHEMICAL JOURNAL

A Simple Hanging Drop Cell Culture Protocol for Generation of 3D Spheroids

(2011) Ramsey Foty   Jove-Journal of Visualized Experiments

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

(2009) S. Veeriah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA