BIRC3 and BIRC5: multi‐faceted inhibitors in cancer

Comprehensive molecular characterization of inhibitors of apoptosis proteins (IAPs) for therapeutic targeting in cancer

(2020) Jianfeng Liang et al.   BMC Medical Genomics

Aberrant expression of Wnt/β-catenin signaling pathway genes in aggressive malignant gastric gastrointestinal stromal tumors

(2020) Keiichi Fujiya et al.   EJSO

BIRC3 mutations in chronic lymphocytic leukemia – uncommon and unfavorable

(2020) Eugen Tausch et al.   HAEMATOLOGICA

Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial

(2020) Stuart J. Blakemore et al.   LEUKEMIA

Subcellular Compartmentalization of Survivin is Associated with Biological Aggressiveness and Prognosis in Prostate Cancer

(2020) Jan K. Hennigs et al.   Scientific Reports

Autophagy in the physiological endometrium and cancer

(2020) Laura Devis-Jauregui et al.   Autophagy

Evaluation of artesunate for the treatment of adult T-cell leukemia/lymphoma

(2020) Chie Ishikawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Proteasome inhibitors and Smac mimetics cooperate to induce cell death in Diffuse Large B‐cell Lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis

(2020) Anna Dietz et al.   INTERNATIONAL JOURNAL OF CANCER

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

Identification of Crucial Genes Associated With Immune Cell Infiltration in Hepatocellular Carcinoma by Weighted Gene Co-expression Network Analysis

(2020) Dengchuan Wang et al.   Frontiers in Genetics

Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies

(2020) Maxime Jullien et al.   Cells

Construction and Validation of an Autophagy-Related Prognostic Risk Signature for Survival Predicting in Clear Cell Renal Cell Carcinoma Patients

(2020) Huiying Yang et al.   Frontiers in Oncology

BCL2-Family Dysregulation in B-Cell Malignancies: From Gene Expression Regulation to a Targeted Therapy Biomarker

(2019) Benoît Tessoulin et al.   Frontiers in Oncology

Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management

(2019) Preetesh Jain et al.   AMERICAN JOURNAL OF HEMATOLOGY

γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia

(2019) Noemie Luong-Gardiol et al.   CANCER CELL

Survivin at a glance

(2019) Sally P. Wheatley et al.   JOURNAL OF CELL SCIENCE

Ribosomal DNA as DAMPs Signal for MCF7 Cancer Cells

(2019) Elena M. Malinovskaya et al.   Frontiers in Oncology

Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia

(2019) Fary Diop et al.   HAEMATOLOGICA

Cancer therapeutics using survivin BIRC5 as a target: what can we do after over two decades of study?

(2019) Fengzhi Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Gene expression comparison between primary triple‐negative breast cancer and paired axillary and sentinel lymph node metastasis

(2019) Marissa K. Srour et al.   Breast Journal

Selinexor (KTP-330) - a selective inhibitor of nuclear export (SINE): anti-tumor activity in diffuse large B-cell lymphoma (DLBCL)

(2019) Sharon Ben-Barouch et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Biallelic BIRC3 inactivation in chronic lymphocytic leukaemia patients with 11q deletion identifies a subgroup with very aggressive disease

(2018) Sara Raponi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Ibrutinib resistance in mantle cell lymphoma: clinical, molecular and treatment aspects

(2018) Oshrat Hershkovitz-Rokah et al.   BRITISH JOURNAL OF HAEMATOLOGY

BCL-2 as therapeutic target for hematological malignancies

(2018) Guilherme Fleury Perini et al.   Journal of Hematology & Oncology

Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors

(2018) Ana Bizarro et al.   MOLECULES

The expression of inhibitor of bruton’s tyrosine kinase gene is progressively up regulated in the clinical course of chronic lymphocytic leukaemia conferring resistance to apoptosis

(2018) Francesco Albano et al.   Cell Death & Disease

p53 expression and subcellular survivin localization improve the diagnosis and prognosis of patients with diffuse astrocytic tumors

(2018) Roberta Soares Faccion et al.   CELLULAR ONCOLOGY

Epidemiology and Management of Hepatocellular Carcinoma

(2018) Laura Kulik et al.   GASTROENTEROLOGY

Clinical utility of recently identified diagnostic, prognostic, and predictive molecular biomarkers in mature B-cell neoplasms

(2017) Arantza Onaindia et al.   MODERN PATHOLOGY

Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer

(2017) Priyanka G. Bhosale et al.   Translational Oncology

Survivin DEx3 as a biomarker of thyroid cancers: A study at the mRNA and protein level

(2017) Joanna Waligórska-Stachura et al.   Oncology Letters

Recurring Amplification at 11q22.1-q22.2 Locus Plays an Important Role in Lymph Node Metastasis and Radioresistance in OSCC

(2017) Priyanka G. Bhosale et al.   Scientific Reports

Survivin, caspase-3 and MIB-1 expression in astrocytic tumors of various grades

(2016) Agnieszka Lebelt et al.   Advances in Medical Sciences

MCPIP1 Selectively Destabilizes Transcripts Associated with an Antiapoptotic Gene Expression Program in Breast Cancer Cells That Can Elicit Complete Tumor Regression

(2016) Wenbao Lu et al.   CANCER RESEARCH

Integrative systems medicine approaches to identify molecular targets in lymphoid malignancies

(2016) Raffaele Frazzi et al.   Journal of Translational Medicine

Survivin and gliomas: A literature review

(2016) Rosilin Kotakkathu Varughese et al.   Oncology Letters

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

(2016) Sonja I. Berndt et al.   Nature Communications

Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic

(2016) Kumudha Balakrishnan et al.   Oncotarget

Analysis of the inhibitors of apoptosis identifies BIRC3 as a facilitator of malignant progression in glioma

(2016) Loyola V. Gressot et al.   Oncotarget

BIRC3 is a novel driver of therapeutic resistance in Glioblastoma

(2016) Dapeng Wang et al.   Scientific Reports

Racial differences in three major NHL subtypes: Descriptive epidemiology

(2015) Yang Li et al.   Cancer Epidemiology

Promises and Challenges of Smac Mimetics as Cancer Therapeutics

(2015) S. Fulda   CLINICAL CANCER RESEARCH

Broad targeting of resistance to apoptosis in cancer

(2015) Ramzi M. Mohammad et al.   SEMINARS IN CANCER BIOLOGY

Predicting Prognosis in Chronic Lymphocytic Leukemia in the Contemporary Era

(2015) Chadi Nabhan et al.   JAMA Oncology

Distinctive effects of the cellular inhibitor of apoptosis protein c-IAP2 through stabilization by XIAP in glioblastoma multiforme cells

(2014) Wensheng Yang et al.   CELL CYCLE

ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial

(2014) M. J. J. Rose-Zerilli et al.   HAEMATOLOGICA

NOTCH1, SF3B1, BIRC3andTP53mutations in patients with chronic lymphocytic leukemia undergoing first-line treatment: correlation with biological parameters and response to treatment

(2014) Sabina Chiaretti et al.   LEUKEMIA & LYMPHOMA

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma

(2014) S N Brun et al.   ONCOGENE

Genetic Abnormalities in Chronic Lymphocytic Leukemia: Where We Are and Where We Go

(2014) Anna Puiggros et al.   Biomed Research International

Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma

(2013) Rami Rahal et al.   NATURE MEDICINE

Vorinostat-induced autophagy switches from a death-promoting to a cytoprotective signal to drive acquired resistance

(2013) D Dupéré-Richer et al.   Cell Death & Disease

Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia

(2012) D. Rossi et al.   BLOOD

Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia

(2012) D. Rossi et al.   BLOOD

Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression

(2012) Eun-Ryeong Hahm et al.   CANCER LETTERS

Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non-Small Cell Lung Cancer

(2012) T. Shimamura et al.   CLINICAL CANCER RESEARCH

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

(2012) John A. Flygare et al.   JOURNAL OF MEDICINAL CHEMISTRY

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2005-2009

(2012) T. A. Dolecek et al.   NEURO-ONCOLOGY

Alteration of BIRC3 and multiple other NF- B pathway genes in splenic marginal zone lymphoma

(2011) D. Rossi et al.   BLOOD

Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells

(2011) Guangmin Xi et al.   CANCER LETTERS

Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2

(2011) M Darding et al.   CELL DEATH AND DIFFERENTIATION

Antitumor Activity of YM155, a Selective Small-Molecule Survivin Suppressant, Alone and in Combination with Docetaxel in Human Malignant Melanoma Models

(2011) Kentaro Yamanaka et al.   CLINICAL CANCER RESEARCH

Core signaling pathways of survival/death in autophagy-related cancer networks

(2011) Shu-ya Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization

(2011) Rebecca Feltham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous knockdown of survivin improves chemotherapeutic response in ALL models

(2011) D J Morrison et al.   LEUKEMIA

Mechanisms and functional consequences of PDEF protein expression loss during prostate cancer progression

(2011) David P. Turner et al.   PROSTATE

Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells

(2009) Donglei Liu et al.   MEDICAL ONCOLOGY

Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and Overcomes Kinase Inhibitor Resistance

(2008) T. Shimamura et al.   CANCER RESEARCH

The mechanism of peptide-binding specificity of IAP BIR domains

(2008) B P Eckelman et al.   CELL DEATH AND DIFFERENTIATION

The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation

(2008) Pauline J. van der Watt et al.   INTERNATIONAL JOURNAL OF CANCER

Survivin Antisense Oligonucleotides Effectively Radiosensitize Colorectal Cancer Cells in Both Tissue Culture and Murine Xenograft Models

(2008) Franz Rödel et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Clinical significance of p53 alterations in surgically treated prostate cancers

(2008) Thorsten Schlomm et al.   MODERN PATHOLOGY