Macrophage-Mediated Inflammation in Skin Wound Healing

Murine macrophages or their secretome delivered in alginate dressings enhance impaired wound healing in diabetic mice

(2022) Georgios Theocharidis et al.   BIOMATERIALS

MicroRNA 21 Elicits a Pro-inflammatory Response in Macrophages, with Exosomes Functioning as Delivery Vehicles

(2021) Radha Madhyastha et al.   INFLAMMATION

Macrophage-mediated inflammation in diabetic wound repair

(2021) Sonya J. Wolf et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Advanced Biomaterials for Regulating Polarization of Macrophages in Wound Healing

(2021) Jiayi Mao et al.   ADVANCED FUNCTIONAL MATERIALS

Exosomes laden self-healing injectable hydrogel enhances diabetic wound healing via regulating macrophage polarization to accelerate angiogenesis

(2021) Kai Wang et al.   CHEMICAL ENGINEERING JOURNAL

Macrophage polarization and diabetic wound healing

(2021) Amanda E. Louiselle et al.   Translational Research

The influence of hyperglycemia on neutrophil extracellular trap formation and endothelial glycocalyx damage in a mouse model of type 2 diabetes

(2020) Tatsuhiko Hirota et al.   MICROCIRCULATION

Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair

(2020) Brett A. Shook et al.   Cell Stem Cell

Role of microRNA-21 and Its Underlying Mechanisms in Inflammatory Responses in Diabetic Wounds

(2020) Cole Liechty et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair

(2020) Frank M. Davis et al.   JOURNAL OF IMMUNOLOGY

Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing

(2020) Patricia M. Seraphim et al.   LIFE SCIENCES

Attack of the NETs! NETosis primes IL-1β-mediated inflammation in diabetic foot ulcers

(2020) Man K.S. Lee et al.   CLINICAL SCIENCE

Palmitate‐TLR4 signaling regulates the histone demethylase, JMJD3, in macrophages and impairs diabetic wound healing

(2020) Frank M. Davis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing

(2020) Xiaoju Zhou et al.   ACS Nano

Mechanistic Actions of microRNAs in Diabetic Wound Healing

(2020) Marija Petkovic et al.   Cells

Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair

(2020) Frank M. Davis et al.   JCI Insight

Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin

(2020) Yanyun Jiang et al.   JCI Insight

Critical limb ischemia: Current and novel therapeutic strategies

(2019) Mohammadhossein Hassanshahi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

(2019) Christian F. Guerrero-Juarez et al.   Nature Communications

Macrophage metabolism: a wound‐healing perspective

(2019) George Caputa et al.   IMMUNOLOGY AND CELL BIOLOGY

Immune aging in diabetes and its implications in wound healing

(2019) J. Moura et al.   CLINICAL IMMUNOLOGY

Bone marrow sinusoidal endothelium as a facilitator/regulator of cell egress from the bone marrow

(2019) Mohammadhossein Hassanshahi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves

(2019) Julia Kolter et al.   IMMUNITY

The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair

(2019) Andrew S. Kimball et al.   IMMUNITY

Macrophage Polarization in Physiological and Pathological Pregnancy

(2019) Yongli Yao et al.   Frontiers in Immunology

One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages

(2019) Weiwei Yu et al.   MOLECULAR CELL

Accelerated wound healing in diabetic mice by miRNA-497 and its anti-inflammatory activity

(2019) Eunmi Ban et al.   BIOMEDICINE & PHARMACOTHERAPY

Ly6CHiBlood Monocyte/Macrophage Drive Chronic Inflammation and Impair Wound Healing in Diabetes MellitusHighlights

(2018) Andrew Kimball et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vitamin D ameliorates impaired wound healing in streptozotocin-induced diabetic mice by suppressing NF-κB-mediated inflammatory genes

(2018) YiFeng Yuan et al.   BIOSCIENCE REPORTS

Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity

(2018) Sofia Pavlou et al.   BMC IMMUNOLOGY

Fetal monocytes and the origins of tissue-resident macrophages

(2018) Guillaume Hoeffel et al.   CELLULAR IMMUNOLOGY

Macrophage-derived GPNMB accelerates skin healing

(2018) Walison N. Silva et al.   EXPERIMENTAL DERMATOLOGY

Interleukin-23 regulates interleukin-17 expression in wounds, and its inhibition accelerates diabetic wound healing through the alteration of macrophage polarization

(2018) James Lee et al.   FASEB JOURNAL

Epigenetic modulation of macrophage polarization- perspectives in diabetic wounds

(2018) Sanchari Basu Mallik et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages

(2018) Jinglian Yan et al.   Nature Communications

Macrophages, Wound Healing, and Fibrosis: Recent Insights

(2018) Kate S. Smigiel et al.   Current Rheumatology Reports

The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes

(2018) Paulina Krzyszczyk et al.   Frontiers in Physiology

Perilipin 1 (Plin1) deficiency promotes inflammatory responses in lean adipose tissue through lipid dysregulation

(2018) Jee Hyung Sohn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methotrexate chemotherapy-induced damages in bone marrow sinusoids: An in vivo and in vitro study

(2018) Mohamamdhossein Hassanshahi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Insulin promotes macrophage phenotype transition through PI3K/Akt and PPAR-γ signaling during diabetic wound healing

(2018) Tianyi Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats

(2018) Mohammadhossein Hassanshahi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Adipose‐derived stem cells for wound healing

(2018) Alireza Hassanshahi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting epigenetic mechanisms in diabetic wound healing

(2018) Aaron den Dekker et al.   Translational Research

Epigenetic mechanisms of macrophage activation in type 2 diabetes

(2017) Mohamed Ahmed et al.   IMMUNOBIOLOGY

Transcriptome analysis of IL-10-stimulated (M2c) macrophages by next-generation sequencing

(2017) Emily B. Lurier et al.   IMMUNOBIOLOGY

Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing

(2017) Anna E. Boniakowski et al.   JOURNAL OF IMMUNOLOGY

Macrophage functions in lean and obese adipose tissue

(2017) Dylan Thomas et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice

(2017) Malte Kölling et al.   MOLECULAR THERAPY

Inflammation and metabolism in tissue repair and regeneration

(2017) Sabine A. Eming et al.   SCIENCE

Tissue-specific contribution of macrophages to wound healing

(2017) Carlos M. Minutti et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

NLRP3 Inflammasome Expression and Signaling in Human Diabetic Wounds and in High Glucose Induced Macrophages

(2017) Xiaotian Zhang et al.   Journal of Diabetes Research

MicroRNA: Dynamic Regulators of Macrophage Polarization and Plasticity

(2017) Jezrom Bokcaerin Self-Fordham et al.   Frontiers in Immunology

Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing

(2017) Andrew S. Kimball et al.   Frontiers in Immunology

Metabolism meets immunity: The role of free fatty acid receptors in the immune system

(2016) Elisa Alvarez-Curto et al.   BIOCHEMICAL PHARMACOLOGY

Monocytes and macrophages in tissue repair: Implications for immunoregenerative biomaterial design

(2016) Molly E Ogle et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

IRF8 is the target of SIRT1 for the inflammation response in macrophages

(2016) Yanhui Jia et al.   Innate Immunity

MiR-146a modulates macrophage polarization by inhibiting Notch1 pathway in RAW264.7 macrophages

(2016) Cheng Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

NADPH Oxidases Are Essential for Macrophage Differentiation

(2016) Qing Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of a Mitochondrial Sirtuin Protein, SIRT3, Alters the Inflammatory Phase of Wound Healing

(2016) Anna Boniakowski et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

The Macrophage Switch in Obesity Development

(2016) Angela Castoldi et al.   Frontiers in Immunology

Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation

(2016) Amy R. Johnson et al.   Molecular Metabolism

Temporal phenotypic features distinguish polarized macrophagesin vitro

(2015) David W. Melton et al.   AUTOIMMUNITY

Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation

(2015) Lisardo Boscá et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells

(2015) Jianpeng Sheng et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic–epigenetic crosstalk in macrophage activation

(2015) Jeroen Baardman et al.   Epigenomics

MicroRNA 21 Is a Homeostatic Regulator of Macrophage Polarization and Prevents Prostaglandin E2-Mediated M2 Generation

(2015) Zhuo Wang et al.   PLoS One

The role of macrophage phenotype in vascularization of tissue engineering scaffolds

(2014) Kara L. Spiller et al.   BIOMATERIALS

Epigenetic Changes in Bone Marrow Progenitor Cells Influence the Inflammatory Phenotype and Alter Wound Healing in Type 2 Diabetes

(2014) Katherine A. Gallagher et al.   DIABETES

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Chromatin Decondensation and T Cell Hyperresponsiveness in Diabetes-Associated Hyperglycemia

(2014) Nuria Martinez et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b

(2014) Xiaosong Yang et al.   MOLECULAR ENDOCRINOLOGY

Regulation of Wound Healing and Fibrosis by Hypoxia and Hypoxia-Inducible Factor-1

(2014) Robin J Ruthenborg et al.   MOLECULES AND CELLS

Pro-Inflammatory Chemokine CCL2 (MCP-1) Promotes Healing in Diabetic Wounds by Restoring the Macrophage Response

(2014) Stephen Wood et al.   PLoS One

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

The Epigenetic Regulation of Wound Healing

(2014) Christopher J. Lewis et al.   Advances in Wound Care

Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo

(2013) Nadine Jetten et al.   ANGIOGENESIS

Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice

(2013) R. E. Mirza et al.   DIABETES

Blocking Interleukin-1  Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes

(2013) R. E. Mirza et al.   DIABETES

Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin

(2013) Samira Tamoutounour et al.   IMMUNITY

Macrophage phenotypes during tissue repair

(2013) Margaret L. Novak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Expression of neuropeptides and cytokines in a rabbit model of diabetic neuroischemic wound healing

(2013) Leena Pradhan Nabzdyk et al.   JOURNAL OF VASCULAR SURGERY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitus type 2 patients

(2013) Christoph Krisp et al.   PROTEOMICS

Neutrophils and Wound Repair: Positive Actions and Negative Reactions

(2013) Traci A. Wilgus et al.   Advances in Wound Care

Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice

(2012) Y. Nio et al.   DIABETOLOGIA

Reduced Il17a Expression Distinguishes a Ly6c lo MHCII hi Macrophage Population Promoting Wound Healing

(2012) Mathieu P. Rodero et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Regulation of Macrophage Polarization and Wound Healing

(2012) Christopher J. Ferrante et al.   Advances in Wound Care

Wound Macrophages as Key Regulators of Repair

(2011) Samielle K. Brancato et al.   AMERICAN JOURNAL OF PATHOLOGY

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

Macrophages and Tissue Injury: Agents of Defense or Destruction?

(2011) Debra L. Laskin et al.   Annual Review of Pharmacology and Toxicology

Macrophages in skin injury and repair

(2011) Babak Mahdavian Delavary et al.   IMMUNOBIOLOGY

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

A Membrane Protease Regulates Energy Production in Macrophages by Activating Hypoxia-inducible Factor-1 via a Non-proteolytic Mechanism

(2010) Takeharu Sakamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

Intracellular Adenosine Triphosphate Delivery Enhanced Skin Wound Healing in Rabbits

(2009) Jianpu Wang et al.   ANNALS OF PLASTIC SURGERY

Epigenetic regulation of the alternatively activated macrophage phenotype

(2009) M. Ishii et al.   BLOOD

HIF-1 in the inflammatory microenvironment

(2009) Nathalie Dehne et al.   EXPERIMENTAL CELL RESEARCH

Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways

(2009) Karine Lolmede et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Keratinocyte Migration, Proliferation, and Differentiation in Chronic Ulcers From Patients With Diabetes and Normal Wounds

(2008) Marcia L. Usui et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

MMP-9 Sheds the β2Integrin Subunit (CD18) from Macrophages

(2008) Tomáš Vaisar et al.   MOLECULAR & CELLULAR PROTEOMICS

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark