Journal
EXPERIMENTAL DERMATOLOGY
Volume 27, Issue 6, Pages 630-635Publisher
WILEY
DOI: 10.1111/exd.13524
Keywords
GPNMB; macrophages; skin; wound healing
Categories
Funding
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais [RED-00313-16]
- REMETTEC [RED-00570-16]
- National Institute of Health [1R01CA179072-01A1]
- American Cancer Society [124443-MRSG-13-121-01-CDD]
- Instituto Serrapilheira [Serra-1708-15285]
- Pro-reitoria de Pesquisa/Universidade Federal de Minas Gerais (PRPq/UFMG) [05/2016]
Ask authors/readers for more resources
Healingis a vital response important for the re-establishment of the skin integrity following injury. Delayedor aberrant dermal wound healingleads to morbidity in patients. The development of therapies to improve dermal healing would be useful. Currently, the design of efficient treatments is stalled by the lack of detailed knowledge about the cellular and molecular mechanisms involved in wound healing. Recently, using state-of-the-art technologies, it was revealed that macrophages signal via GPNMB to mesenchymal stem cells, accelerating skin healing. Strikingly, transplantation of macrophages expressing GPNMB improves skin healing in GPNMB-mutant mice. Additionally, topical treatment with recombinant GPNMB restored mesenchymal stem cells recruitment and accelerated wound closure in the diabetic skin. From a drug development perspective, this GPNMB is a new candidate for skin healing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available