Palmitate‐TLR4 signaling regulates the histone demethylase, JMJD3, in macrophages and impairs diabetic wound healing

Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair

(2020) Frank M. Davis et al.   JOURNAL OF IMMUNOLOGY

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

(2018) Graeme I. Lancaster et al.   Cell Metabolism

Dysfunctional Wound Healing in Diabetic Foot Ulcers: New Crossroads

(2018) Frank M. Davis et al.   Current Diabetes Reports

The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation

(2018) Rasheed Ahmad et al.   JOURNAL OF IMMUNOLOGY

Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma

(2018) Timothy L. Lochmann et al.   Science Translational Medicine

Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation

(2017) Marta Riera-Borrull et al.   JOURNAL OF IMMUNOLOGY

Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2

(2017) Yi Wang et al.   Nature Communications

JMJD3 and NF-κB-dependent activation of Notch1 gene is required for keratinocyte migration during skin wound healing

(2017) Jungtae Na et al.   Scientific Reports

Histone H3K27 Demethylase JMJD3 in Cooperation with NF-κB Regulates Keratinocyte Wound Healing

(2016) Jungtae Na et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fatty acid induced metabolic memory involves alterations in renal histone H3K36me2 and H3K27me3

(2016) Sandeep Kumar et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Obesity Statistics

(2016) Kristy Breuhl Smith et al.   PRIMARY CARE

Obesity: An Immunometabolic Perspective

(2016) Indrani Ray et al.   Frontiers in Endocrinology

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

(2015) Robert Caesar et al.   Cell Metabolism

Macrophage PPARγ and impaired wound healing in type 2 diabetes

(2015) Rita E Mirza et al.   JOURNAL OF PATHOLOGY

Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications

(2015) Gabriele Togliatto et al.   Journal of Diabetes Research

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

(2014) Prabhakara R. Nagareddy et al.   Cell Metabolism

Epigenetic Changes in Bone Marrow Progenitor Cells Influence the Inflammatory Phenotype and Alter Wound Healing in Type 2 Diabetes

(2014) Katherine A. Gallagher et al.   DIABETES

Role of epigenetic mechanisms in the development of chronic complications of diabetes

(2014) Malgorzata Wegner et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Epigenetic mechanisms in diabetic complications and metabolic memory

(2014) Marpadga A. Reddy et al.   DIABETOLOGIA

Pro-Inflammatory Chemokine CCL2 (MCP-1) Promotes Healing in Diabetic Wounds by Restoring the Macrophage Response

(2014) Stephen Wood et al.   PLoS One

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

(2014) Lin Jia et al.   Nature Communications

Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice

(2013) R. E. Mirza et al.   DIABETES

Blocking Interleukin-1  Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes

(2013) R. E. Mirza et al.   DIABETES

Increase of Palmitic Acid Concentration Impairs Endothelial Progenitor Cell and Bone Marrow-Derived Progenitor Cell Bioavailability: Role of the STAT5/PPAR  Transcriptional Complex

(2012) A. Trombetta et al.   DIABETES

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

(2012) G. G. Welstead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes Adversely Affects Macrophages During Atherosclerotic Plaque Regression in Mice

(2011) S. Parathath et al.   DIABETES

Inflammation and wound healing: the role of the macrophage

(2011) Timothy J. Koh et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon

(2010) Qing Zhong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Epigenetic transgenerational actions of environmental factors in disease etiology

(2010) Michael K. Skinner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Epigenetic regulation of the alternatively activated macrophage phenotype

(2009) M. Ishii et al.   BLOOD

The genetics and epigenetics of autoimmune diseases

(2009) Anura Hewagama et al.   JOURNAL OF AUTOIMMUNITY

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark