Inhibition of Chk2 promotes neuroprotection, axon regeneration, and functional recovery after CNS injury

Clinical outcomes of prexasertib monotherapy in recurrent BRCA wild-type high-grade serous ovarian cancer involve innate and adaptive immune responses

(2020) Erika J Lampert et al.   Journal for ImmunoTherapy of Cancer

Treatment of spinal cord injury with mesenchymal stem cells

(2020) Ling Ling Liau et al.   Cell and Bioscience

Polyploidy in the adult Drosophila brain

(2020) Shyama Nandakumar et al.   eLife

GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases

(2020) Daayun Chung et al.   Frontiers in Cell and Developmental Biology

Continuous tracking of startled Drosophila as an alternative to the negative geotaxis climbing assay

(2019) Matthew J. Taylor et al.   JOURNAL OF NEUROGENETICS

CNS penetration and pharmacodynamics of the CHK1 inhibitor prexasertib in a mouse Group 3 medulloblastoma model

(2019) Olivia Campagne et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Prexasertib, a cell cycle checkpoint kinase 1 and 2 inhibitor, in BRCA wild-type recurrent high-grade serous ovarian cancer: a first-in-class proof-of-concept phase 2 study

(2018) Jung-Min Lee et al.   LANCET ONCOLOGY

Non-viral-mediated suppression of AMIGO3 promotes disinhibited NT3-mediated regeneration of spinal cord dorsal column axons

(2018) Sharif Almutiri et al.   Scientific Reports

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

(2017) Edward Fielder et al.   JOURNAL OF ALZHEIMERS DISEASE

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells

(2014) Feng-Ze Wang et al.   APOPTOSIS

Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling

(2014) Vasanthy Vigneswara et al.   BRAIN

Decorin blocks scarring and cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds

(2014) Zubair Ahmed et al.   NEUROBIOLOGY OF DISEASE

Differential cavitation, angiogenesis and wound-healing responses in injured mouse and rat spinal cords

(2014) S. Surey et al.   NEUROSCIENCE

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease

(2014) X.-H. Lu et al.   Science Translational Medicine

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromatin Modifications Associated with DNA Double-strand Breaks Repair as Potential Targets for Neurological Diseases

(2013) Camille Brochier et al.   Neurotherapeutics

Caspase-2 Is Upregulated after Sciatic Nerve Transection and Its Inhibition Protects Dorsal Root Ganglion Neurons from Apoptosis after Serum Withdrawal

(2013) Vasanthy Vigneswara et al.   PLoS One

Amyloid-β1–42 oligomer accelerates senescence in adult hippocampal neural stem/progenitor cells via formylpeptide receptor 2

(2013) N He et al.   Cell Death & Disease

Expression inDrosophilaof Tandem Amyloid β Peptides Provides Insights into Links between Aggregation and Neurotoxicity

(2012) Elena Speretta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Phase I/IIa Clinical Trial of a Recombinant Rho Protein Antagonist in Acute Spinal Cord Injury

(2011) Michael G. Fehlings et al.   JOURNAL OF NEUROTRAUMA

p53- and Bax-Mediated Apoptosis in Injured Rat Spinal Cord

(2011) Ramaprasada Rao Kotipatruni et al.   NEUROCHEMICAL RESEARCH

Targeting DNA damage and repair: Embracing the pharmacological era for successful cancer therapy

(2011) K. Aziz et al.   PHARMACOLOGY & THERAPEUTICS

Ocular neuroprotection by siRNA targeting caspase-2

(2011) Z Ahmed et al.   Cell Death & Disease

The MRN complex in double-strand break repair and telomere maintenance

(2010) Brandon J. Lamarche et al.   FEBS LETTERS

Optic nerve and vitreal inflammation are both RGC neuroprotective but only the latter is RGC axogenic

(2009) Zubair Ahmed et al.   NEUROBIOLOGY OF DISEASE

DNA damage response and neuroprotection

(2007) Inna et al.   Frontiers in Bioscience-Landmark