Article
Biochemistry & Molecular Biology
Lichao Zhong, Zhizhang Yang, Hao Tang, Yifan Xu, Xingyou Liu, Jie Shen
Summary: The decline of climbing behavior in aging fruit flies is a common phenomenon. By analyzing the climbing trajectories of individual fruit flies, it was found that climbing ability decreases with age and is stronger in female fruit flies compared to males.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Cell Biology
Dong Li, Ying Ge, Ze Zhao, Rui Zhu, Xiang Wang, Xiaolin Bi
Summary: The study analyzed the expression profiles of miRNAs and piRNAs in Drosophila during development and DNA damage response, revealing dynamic expression patterns and the key roles of E2f1 and p53 in regulating small ncRNAs. E2f1 may play a major role in modulating miRNAs during development and after X-ray irradiation, showcasing new insights into small ncRNA biology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Adam N. Spierer, Denise Yoon, Chen-Tseh Zhu, David M. Rand
Summary: FreeClimber is an open-source Python-based platform for quantifying Drosophila climbing performance, improving detection by subtracting static backgrounds and offering visualizations for ease of high-throughput automated batch processing.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Biology
Ananya Chakravarti, Heshani N. Thirimanne, Savanna Brown, Brian R. Calvi
Summary: Using Drosophila as a model, this study found that p53 isoforms in fruit flies have functions specific to DNA damage and cell types, similar to mammalian p53 family members in the genotoxic stress response and oocyte quality control.
Article
Oncology
Amr Ghaleb, Lucia Roa, Natalia Marchenko
Summary: The biological consequences of low-dose radiation (LDR) in breast cancer are unclear, while high-dose radiation (HDR) promotes DNA repair and cell cycle arrest. Mutant p53 promotes mammary tumorigenesis following LDR, but has negligible effects on tumors carrying the wild-type p53 allele.
Article
Pharmacology & Pharmacy
Yanting Yang, Xiuhong Zhu, Guohua Yu, Jinbo Ma
Summary: This study demonstrates that Pyxinol can mitigate cisplatin-induced renal injury by attenuating DNA damage response and tubular cell apoptosis. Furthermore, Pyxinol can enhance the in vivo anti-tumor efficacy of cisplatin against xenograft tumors in nude mice. The combination of Pyxinol with cisplatin may represent a beneficial adjunct therapy for cisplatin-based chemotherapeutic regimens in the clinic.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Antonio Baonza, Sara Tur-Gracia, Marina Perez-Aguilera, Carlos Estella
Summary: Cells have evolved mechanisms to respond to DNA damage and maintain genomic integrity. The responses include cell cycle checkpoints, repair mechanisms, and induction of apoptosis. Understanding the coordination between cell proliferation control and apoptosis is crucial for tissue homeostasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ting-Yu Chen, Bu-Miin Huang, Tang K. Tang, Yu-Ying Chao, Xiao-Yi Xiao, Pei-Rong Lee, Li-Yun Yang, Chia-Yih Wang
Summary: The DNA-PK-p53 cascade induces primary cilia formation under genotoxic stress, contributing to the DNA damage response, while lack of this pathway decreases genotoxic stress-induced ciliogenesis. Besides, ciliogenesis is regulated not only by DNA-PK, but also by autophagy.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biochemistry & Molecular Biology
Stefania Gonfloni, Carla Jodice, Bianca Gustavino, Elvia Valentini
Summary: Chemotherapy and radiotherapy are common strategies to fight cancer, but they may cause side effects such as premature ovarian insufficiency and infertility in women. Understanding the mechanisms underlying the loss of follicle reserve due to cancer treatments is crucial in developing clinical strategies to protect ovarian reserve. Recent studies have identified the involvement of p53 and CHK2 in the oocyte response to DNA stressors commonly used in cancer treatment. This review explores the molecular mechanisms of the DNA damage stress response and its crosstalk with signaling pathways related to primordial follicle activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Xiaohu Ren, Jiawen Ruan, Xuerao Lan, Sixia Yang, Desheng Wu, Xinfeng Huang, Hongyu Zhang, Jianjun Liu, Haiyan Huang
Summary: This study identified SET-H3K79me3-p53 as a critical regulatory axis involved in the DNA damage response to TCE exposure.
TOXICOLOGY LETTERS
(2023)
Article
Cell Biology
Ilias Tsochantaridis, Alexandros Kontopoulos, Georgia-Persephoni Voulgaridou, Margaritis Tsifintaris, Charisios Triantafyllou, Aglaia Pappa
Summary: ALDH1B1 plays a protective role in DNA damage and apoptosis in colorectal adenocarcinoma cells, and is associated with the transcriptional activation of DNA repair-related genes.
Review
Biochemistry & Molecular Biology
Lindsey Carlsen, Shengliang Zhang, Xiaobing Tian, Arielle De La Cruz, Andrew George, Taylor E. E. Arnoff, Wafik S. S. El-Deiry
Summary: p53 is a transcription factor that regulates tumor suppressor genes. Mutations in p53 are common in human cancers and can impact immune responses. p53 can induce different cellular responses such as apoptosis, cell cycle arrest, and DNA damage repair by regulating target genes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Oncology
Meiling Zhou, Liang Xiao, Jing Jin, Yin Wang, Peiyu Guo, Jinhua Luo, Magdalena Skonieczna, Ruixue Huang
Summary: This study revealed the epigenetic mechanisms underlying Nano-ZnO-induced DNA damage and EMT. The effect of Nano-ZnO-induced DNA damage through the p53/circRNA_0085439/Ku70 pathway likely contributes to Nano-ZnO-induced cell cytotoxicity and apoptosis. These findings provide important information to further elucidate the molecular mechanisms of Nano-ZnO-induced cytotoxicity and genotoxicity.
CANCER NANOTECHNOLOGY
(2023)
Article
Biology
Joyce Rigal, Ane Martin Anduaga, Elena Bitman, Emma Rivellese, Sebastian Kadener, Michael T. Marr
Summary: This study demonstrates that active transposable elements can act as effectors in the aging process by accelerating aging phenotypes and shortening lifespan in fruit flies. Increased transposable element activity leads to increased sensitivity to oxidative stress and a decline in circadian rhythmicity. Overexpression of the FOXO stress response transcription factor can partially rescue the detrimental effects of increased transposable element activity on lifespan.
Review
Cell Biology
Yu-Hsiu Wang, Michael P. Sheetz
Summary: The mechanisms that maintain genome stability are crucial for preventing tumor progression. Nuclear phosphoinositide lipids play an important role in DNA damage signaling and provide a new signaling interface for DNA repair pathway selection. However, our understanding of the underlying regulatory mechanisms of nuclear phosphoinositides in DNA damage repair is limited due to a lack of techniques for real-time monitoring of changes in these lipids.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kiterie M. E. Faller, Rodrigo Gutierrez-Quintana, Alamin Mohammed, Ahad A. Rahim, Richard I. Tuxworth, Kim Wager, Michael Bond
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2015)
Review
Biochemistry & Molecular Biology
Elena Seranova, Kyle J. Connolly, Malgorzata Zatyka, Tatiana R. Rosenstock, Timothy Barrett, Richard I. Tuxworth, Sovan Sarkar
SIGNALLING MECHANISMS IN AUTOPHAGY
(2017)
Article
Neurosciences
Alamin Mohammed, Megan B. O'Hare, Alice Warley, Guy Tear, Richard I. Tuxworth
NEUROBIOLOGY OF DISEASE
(2017)
Article
Biochemistry & Molecular Biology
Richard I. Tuxworth, Haiyang Chen, Valerie Vivancos, Nancy Carvajal, Xun Huang, Guy Tear
HUMAN MOLECULAR GENETICS
(2011)
Article
Biology
Giulia Povellato, Richard I. Tuxworth, Diane P. Hanger, Guy Tear
Article
Biochemistry & Molecular Biology
Robert J. Huber, Stephanie M. Hughes, Wenfei Liu, Alan Morgan, Richard Tuxworth, Claire Russell
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Multidisciplinary Sciences
Kyle J. Connolly, Megan B. O'Hare, Alamin Mohammed, Katelyn M. Aitchison, Niki C. Anthoney, Matthew J. Taylor, Bryan A. Stewart, Richard I. Tuxworth, Guy Tear
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Zubair Ahmed, Richard I. Tuxworth
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Matthew J. Taylor, Adam M. Thompson, Sharif Alhajlah, Richard Tuxworth, Zubair Ahmed
Summary: DNA double-strand breaks play a crucial role in neurological conditions, and targeting the ATM-Chk2 pathway can slow down neural decline and promote neuroprotection by inhibiting nonhomologous end-joining.
Article
Clinical Neurology
Richard Tuxworth, Matthew J. Taylor, Ane Martin Anduaga, Alaa Hussien-Ali, Sotiroula Chatzimatthaiou, Joanne Longland, Adam M. Thompson, Sharif Almutiri, Pavlos Alifragis, Charalambos P. Kyriacou, Boris Kysela, Zubair Ahmed
BRAIN COMMUNICATIONS
(2019)