O-GlcNAc in cancer biology

O-GlcNAc Transferase Integrates Metabolic Pathways to Regulate the Stability of c-MYC in Human Prostate Cancer Cells

(2013) H. M. Itkonen et al.   CANCER RESEARCH

Resveratrol has anti-leukemic activity associated with decreased O-GlcNAcylated proteins

(2013) Jelena Tomic et al.   EXPERIMENTAL HEMATOLOGY

Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells

(2013) Zhiyuan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GSK-3α Promotes Oncogenic KRAS Function in Pancreatic Cancer via TAK1–TAB Stabilization and Regulation of Noncanonical NF-κB

(2013) Deepali Bang et al.   Cancer Discovery

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Cancer stem cells: In the line of fire

(2012) Malcolm R. Alison et al.   CANCER TREATMENT REVIEWS

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

O-GlcNAc Regulates Pluripotency and Reprogramming by Directly Acting on Core Components of the Pluripotency Network

(2012) Hyonchol Jang et al.   Cell Stem Cell

O-GlcNAc Modification Prevents Peptide-Dependent Acceleration of α-Synuclein Aggregation

(2012) Nicholas P. Marotta et al.   CHEMBIOCHEM

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

(2012) Shalini Pathak et al.   EMBO JOURNAL

Cancer chromosomal instability: therapeutic and diagnostic challenges

(2012) Nicholas McGranahan et al.   EMBO REPORTS

O-Linked β-N-Acetylglucosaminylation (O-GlcNAcylation) in Primary and Metastatic Colorectal Cancer Clones and Effect ofN-Acetyl-β-d-glucosaminidase Silencing on Cell Phenotype and Transcriptome

(2012) Galit Yehezkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Increase inO-LinkedN-Acetylglucosamine Protein Modification Stimulates Chondrogenic Differentiation Bothin Vitroandin Vivo

(2012) Jessica Andrés-Bergós et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role ofO-Linked β-N-Acetylglucosamine Transferase in Prostate Cancer Invasion, Angiogenesis, and Metastasis

(2012) Thomas P. Lynch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Roadblocks for Cellular Reprogramming

(2012) Thomas Vierbuchen et al.   MOLECULAR CELL

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

(2012) W. Yi et al.   SCIENCE

Glucose sensing by ChREBP/MondoA–Mlx transcription factors

(2012) Essi Havula et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Prosurvival role of heat shock factor 1 in the pathogenesis of pancreatobiliary tumors

(2011) Vikas Dudeja et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy

(2011) Wenyi Mi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver

(2011) C. Guinez et al.   DIABETES

Targeting heat shock response pathways to treat pancreatic cancer

(2011) Yi Xia et al.   DRUG DISCOVERY TODAY

Proteotoxic stress of cancer: Implication of the heat-shock response in oncogenesis

(2011) Chengkai Dai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantation

(2011) Qianqian Zhu et al.   MEDICAL ONCOLOGY

Structure of human O-GlcNAc transferase and its complex with a peptide substrate

(2011) Michael B. Lazarus et al.   NATURE

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

(2011) Tracey M Gloster et al.   Nature Chemical Biology

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Polycomb repressive complex 2 is necessary for the normal site-specific O-GlcNAc distribution in mouse embryonic stem cells

(2011) S. A. Myers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein O-GlcNAcylation Is Required for Fibroblast Growth Factor Signaling in Drosophila

(2011) D. Mariappa et al.   Science Signaling

Augmented O-GlcNAc signaling attenuates oxidative stress and calcium overload in cardiomyocytes

(2010) Gladys A. Ngoh et al.   AMINO ACIDS

The role of O-linked GlcNAc modification on the glucose response of ChREBP

(2010) Haruhiko Sakiyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GlcNAcylation Plays an Essential Role in Breast Cancer Metastasis

(2010) Y. Gu et al.   CANCER RESEARCH

Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition

(2010) Sang Yoon Park et al.   EMBO JOURNAL

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of mammalian muscle type 6-phosphofructo-1-kinase and its implication for the control of the metabolism

(2010) Mauro Sola-Penna et al.   IUBMB LIFE

O-Linked β-N-acetylglucosamine (O-GlcNAc) Regulates Stress-induced Heat Shock Protein Expression in a GSK-3β-dependent Manner

(2010) Zahra Kazemi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia

(2010) Y Shi et al.   LEUKEMIA

Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc

(2010) Chin Fen Teo et al.   Nature Chemical Biology

Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1

(2010) S A Caldwell et al.   ONCOGENE

Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Cytokinesis

(2010) Z. Wang et al.   Science Signaling

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

(2009) Yadi Wu et al.   CANCER CELL

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

O-GlcNAcylation enhances FOXO4 transcriptional regulation in response to stress

(2009) Shiuh-Rong Ho et al.   FEBS LETTERS

Two genetic pathways, t(1;10) and amplification of 3p11-12, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesions

(2009) Karolin H Hallor et al.   JOURNAL OF PATHOLOGY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Loss of p53 enhances catalytic activity of IKK  through O-linked  -N-acetyl glucosamine modification

(2009) K. Kawauchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation

(2009) X. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The angiogenic switch in carcinogenesis

(2009) Vanessa Baeriswyl et al.   SEMINARS IN CANCER BIOLOGY

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Is cancer a disease of abnormal cellular metabolism? New angles on an old idea

(2008) Ralph J Deberardinis   GENETICS IN MEDICINE

Glutamine Induces Heat Shock Protein Expression Via O-Glycosylation and Phosphorylation of HSF-1 and Sp1

(2008) Kristen D. Singleton et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly

(2008) Takbum Ohn et al.   NATURE CELL BIOLOGY

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE