Dynamic Fluid Flow Exacerbates the (Pro-)Inflammatory Effects of Aerosolised Engineered Nanomaterials In Vitro

Toxicological effects of zinc oxide nanoparticle exposure: an in vitro comparison between dry aerosol air-liquid interface and submerged exposure systems

(2021) Karin Lovén et al.   Nanotoxicology

Screening for Effects of Inhaled Nanoparticles in Cell Culture Models for Prolonged Exposure

(2021) Claudia Meindl et al.   Nanomaterials

A Bioinspired in vitro Lung Model to Study Particokinetics of Nano-/Microparticles Under Cyclic Stretch and Air-Liquid Interface Conditions

(2021) Ali Doryab et al.   Frontiers in Bioengineering and Biotechnology

Development of an In Vitro Airway Epithelial–Endothelial Cell Culture Model on a Flexible Porous Poly(Trimethylene Carbonate) Membrane Based on Calu-3 Airway Epithelial Cells and Lung Microvascular Endothelial Cells

(2021) Thijs Pasman et al.   Membranes

Inter-laboratory variability of A549 epithelial cells grown under submerged and air-liquid interface conditions

(2021) Hana Barosova et al.   TOXICOLOGY IN VITRO

An in vitro assessment of the toxicity of two-dimensional synthetic and natural layered silicates

(2021) Krystyna Maciaszek et al.   TOXICOLOGY IN VITRO

Differences in cytotoxicity of lung epithelial cells exposed to titanium dioxide nanofibers and nanoparticles: Comparison of air-liquid interface and submerged cell cultures

(2020) Estefany I. Medina-Reyes et al.   TOXICOLOGY IN VITRO

Development of a dynamic in vitro stretch model of the alveolar interface with aerosol delivery

(2020) Daniele Cei et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quartz crystal microbalances (QCM) are suitable for real-time dosimetry in nanotoxicological studies using VITROCELL®Cloud cell exposure systems

(2020) Yaobo Ding et al.   Particle and Fibre Toxicology

Air–Liquid Interface Exposure of Lung Epithelial Cells to Low Doses of Nanoparticles to Assess Pulmonary Adverse Effects

(2020) Silvia Diabaté et al.   Nanomaterials

Air-liquid interface culture changes surface properties of A549 cells

(2019) Kristin Öhlinger et al.   TOXICOLOGY IN VITRO

Alveolar Macrophages

(2018) Nikita Joshi et al.   CELLULAR IMMUNOLOGY

Reduction of PM2.5 toxicity on human alveolar epithelial cells A549 by tea polyphenols

(2018) Ying Zhang et al.   JOURNAL OF FOOD BIOCHEMISTRY

Differences between co-cultures and monocultures in testing the toxicity of particulate matter derived from log wood and pellet combustion

(2018) Stefanie Kasurinen et al.   PLoS One

Air-Liquid Interface: Relevant In Vitro Models for Investigating Air Pollutant-Induced Pulmonary Toxicity

(2018) Swapna Upadhyay et al.   TOXICOLOGICAL SCIENCES

Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions

(2018) Pieter S. Hiemstra et al.   TOXICOLOGY IN VITRO

A novel dynamic multicellular co-culture system for studying individual blood-brain barrier cell types in brain diseases and cytotoxicity testing

(2018) Patricia Miranda-Azpiazu et al.   Scientific Reports

Effect of the surface charge density of nanoparticles on their translocation across pulmonary surfactant monolayer: a molecular dynamics simulation

(2017) Peng Chen et al.   MOLECULAR SIMULATION

In vitro toxicoproteomic analysis of A549 human lung epithelial cells exposed to urban air particulate matter and its water-soluble and insoluble fractions

(2017) Ngoc Q. Vuong et al.   Particle and Fibre Toxicology

Regulating temperature and relative humidity in air–liquid interface in vitro systems eliminates cytotoxicity resulting from control air exposures

(2017) Jose Zavala et al.   Toxicology Research

Fast-track development of an in vitro 3D lung/immune cell model to study Aspergillus infections

(2017) P. Chandorkar et al.   Scientific Reports

Lost in Trans-IL-6 Signaling: Alveolar Type II Cell Death in Emphysema

(2016) Irina Petrache et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials

(2016) Amy J. Clippinger et al.   ARCHIVES OF TOXICOLOGY

Macrophages: sentinels and regulators of the immune system

(2016) Lars Franken et al.   CELLULAR MICROBIOLOGY

Surface area is the biologically most effective dose metric for acute nanoparticle toxicity in the lung

(2016) Otmar Schmid et al.   JOURNAL OF AEROSOL SCIENCE

Modeling the fluid-dynamics and oxygen consumption in a porous scaffold stimulated by cyclic squeeze pressure

(2016) Marco Ferroni et al.   MEDICAL ENGINEERING & PHYSICS

Air-liquid interface exposure to aerosols of poorly soluble nanomaterials induces different biological activation levels compared to exposure to suspensions

(2016) Thomas Loret et al.   Particle and Fibre Toxicology

Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype

(2016) James Ross Cooper et al.   PLoS One

Mass or total surface area with aerosol size distribution as exposure metrics for inflammatory, cytotoxic and oxidative lung responses in rats exposed to titanium dioxide nanoparticles

(2016) A Noël et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

A novel dual-flow bioreactor simulates increased fluorescein permeability in epithelial tissue barriers

(2014) Serena Giusti et al.   Biotechnology Journal

Characterizations of coal fly ash nanoparticles and induced in vitro toxicity in cell lines

(2014) Bharathi Sambandam et al.   JOURNAL OF NANOPARTICLE RESEARCH

An in vitro testing strategy towards mimicking the inhalation of high aspect ratio nanoparticles

(2014) Carola Endes et al.   Particle and Fibre Toxicology

IL-6 in Inflammation, Immunity, and Disease

(2014) T. Tanaka et al.   Cold Spring Harbor Perspectives in Biology

Mimicking exposures to acute and lifetime concentrations of inhaled silver nanoparticles by two different in vitro approaches

(2014) Fabian Herzog et al.   Beilstein Journal of Nanotechnology

Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages

(2014) Dagmar A Kuhn et al.   Beilstein Journal of Nanotechnology

Silica nanoparticles are less toxic to human lung cells when deposited at the air–liquid interface compared to conventional submerged exposure

(2014) Alicja Panas et al.   Beilstein Journal of Nanotechnology

Design Criteria for Generating Physiologically Relevant In Vitro Models in Bioreactors

(2014) Giorgio Mattei et al.   Processes

An improved 3D tetraculture system mimicking the cellular organisation at the alveolar barrier to study the potential toxic effects of particles on the lung

(2013) Sebastian G Klein et al.   Particle and Fibre Toxicology

Exposure of silver-nanoparticles and silver-ions to lung cells in vitro at the air-liquid interface

(2013) Fabian Herzog et al.   Particle and Fibre Toxicology

Role of size and surface area for pro-inflammatory responses to silica nanoparticles in epithelial lung cells: Importance of exposure conditions

(2013) T. Skuland et al.   TOXICOLOGY IN VITRO

Role of IL-6 in Asthma and Other Inflammatory Pulmonary Diseases

(2012) Mercedes Rincon et al.   International Journal of Biological Sciences

Effects of flame made zinc oxide particles in human lung cells - a comparison of aerosol and suspension exposures

(2012) David O Raemy et al.   Particle and Fibre Toxicology

Terminology for biorelated polymers and applications (IUPAC Recommendations 2012)

(2012) Michel Vert et al.   PURE AND APPLIED CHEMISTRY

Cellular responses induced by cerium oxide nanoparticles: induction of intracellular calcium level and oxidative stress on culture cells

(2011) M. Horie et al.   JOURNAL OF BIOCHEMISTRY

Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro

(2011) Stephan Hackenberg et al.   TOXICOLOGY IN VITRO

Engineered nanomaterials: exposures, hazards, and risk prevention

(2011) Robert A Yokel et al.   Journal of Occupational Medicine and Toxicology

Deposition and biokinetics of inhaled nanoparticles

(2010) Marianne Geiser et al.   Particle and Fibre Toxicology

Respiratory syncytial virus infection alters surfactant protein A expression in human pulmonary epithelial cells by reducing translation efficiency

(2009) Shirley R. Bruce et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY