Design Criteria for Generating Physiologically Relevant In Vitro Models in Bioreactors

Hepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicity

(2013) L. Schyschka et al.   ARCHIVES OF TOXICOLOGY

Bioengineering heart tissue for in vitro testing

(2013) Elisa Cimetta et al.   CURRENT OPINION IN BIOTECHNOLOGY

Optimal periodic perfusion strategy for robust long-term microfluidic cell culture

(2013) Stefano Giulitti et al.   LAB ON A CHIP

Mathematical analysis of oxygen transfer through polydimethylsiloxane membrane between double layers of cell culture channel and gas chamber in microfluidic oxygenator

(2013) Min-Cheol Kim et al.   Microfluidics and Nanofluidics

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonsteady State Oxygen Transport in Engineered Tissue: Implications for Design

(2013) Seema M. Ehsan et al.   TISSUE ENGINEERING PART A

A thin-walled polydimethylsiloxane bioreactor for high-density hepatocyte sandwich culture

(2012) Guo-Dong Sean Tan et al.   BIOTECHNOLOGY AND BIOENGINEERING

A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity

(2012) Anna Astashkina et al.   PHARMACOLOGY & THERAPEUTICS

A flexible bioreactor system for constructing in vitro tissue and organ models

(2011) Federico Vozzi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes

(2011) Bruna Vinci et al.   Biotechnology Journal

An in vitro model of glucose and lipid metabolism in a multicompartmental bioreactor

(2011) Bruna Vinci et al.   Biotechnology Journal

Finite element analysis of oxygen transport in microfluidic cell culture devices with varying channel architectures, perfusion rates, and materials

(2011) M. Zahorodny-Burke et al.   CHEMICAL ENGINEERING SCIENCE

In vitro platforms for tissue engineering: implications for basic research and clinical translation

(2011) Jeroen Rouwkema et al.   Journal of Tissue Engineering and Regenerative Medicine

A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets

(2011) Peter Buchwald   Theoretical Biology and Medical Modelling

Metabolic Control Through Hepatocyte and Adipose Tissue Cross-Talk in a Multicompartmental Modular Bioreactor

(2011) Maria Angela Guzzardi et al.   TISSUE ENGINEERING PART A

Flow-regulated glucose and lipid metabolism in adipose tissue, endothelial cell and hepatocyte cultures in a modular bioreactor

(2010) Bruna Vinci et al.   Biotechnology Journal

Integration ofin silicoandin vitroplatforms for pharmacokinetic–pharmacodynamic modeling

(2010) Jong Hwan Sung et al.   Expert Opinion on Drug Metabolism & Toxicology

Effect of three-dimensional expansion and cell seeding density on the cartilage-forming capacity of human articular chondrocytes in type II collagen sponges

(2010) Silvia E. Francioli et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

A Review of Three-Dimensional In Vitro Tissue Models for Drug Discovery and Transport Studies

(2010) Nelita T. Elliott et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Microfluidic dissolved oxygen gradient generator biochip as a useful tool in bacterial biofilm studies

(2010) Maciej Skolimowski et al.   LAB ON A CHIP

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro microscale systems for systematic drug toxicity study

(2009) Jong Hwan Sung et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Quantitative inference of cellular parameters from microfluidic cell culture systems

(2009) Khamir Mehta et al.   BIOTECHNOLOGY AND BIOENGINEERING

In vitro liver model using microfabricated scaffolds in a modular bioreactor

(2009) Bruna Vinci et al.   Biotechnology Journal

Why animal studies are often poor predictors of human reactions to exposure

(2009) Michael B Bracken   JOURNAL OF THE ROYAL SOCIETY OF MEDICINE

Biological implications of polydimethylsiloxane-based microfluidic cell culture

(2009) Keil J. Regehr et al.   LAB ON A CHIP

FEM-based oxygen consumption and cell viability models for avascular pancreatic islets

(2009) Peter Buchwald   Theoretical Biology and Medical Modelling

Radial flow hepatocyte bioreactor using stacked microfabricated grooved substrates

(2007) Jaesung Park et al.   BIOTECHNOLOGY AND BIOENGINEERING

Enhanced maintenance and functions of rat hepatocytes induced by combination of on-site oxygenation and coculture with fibroblasts

(2007) Masaki Nishikawa et al.   JOURNAL OF BIOTECHNOLOGY