Establishment and large-scale validation of a three-dimensional tumor model on an array chip for anticancer drug evaluation

An integrated biomimetic array chip for establishment of collagen‐based 3D primary human hepatocyte model for prediction of clinical drug‐induced liver injury

(2021) Rong‐Rong Xiao et al.   BIOTECHNOLOGY AND BIOENGINEERING

Mechanical Studies of the Third Dimension in Cancer: From 2D to 3D Model

(2021) Francesca Paradiso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages

(2021) Ola Habanjar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Harnessing the predictive power of preclinical models for oncology drug development

(2021) Alexander Honkala et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting Strategies for Tissue-Specific Drug Delivery

(2020) Zongmin Zhao et al.   CELL

An overview of drug discovery and development

(2020) Nurken Berdigaliyev et al.   Future Medicinal Chemistry

Synthetic alternatives to Matrigel

(2020) Elizabeth A. Aisenbrey et al.   Nature Reviews Materials

Establishment of patient-derived cancer organoids for drug-screening applications

(2020) Else Driehuis et al.   Nature Protocols

The extracellular matrix in tumor progression and metastasis

(2019) Johannes A. Eble et al.   CLINICAL & EXPERIMENTAL METASTASIS

Inhibiting casein kinase 2 overcomes paclitaxel resistance in gastric cancer

(2019) Minkyu Jung et al.   Gastric Cancer

The role of mouse tumour models in the discovery and development of anticancer drugs

(2019) Christopher R. Ireson et al.   BRITISH JOURNAL OF CANCER

Effects of culture method on response to EGFR therapy in head and neck squamous cell carcinoma cells

(2019) Jose M. Ayuso et al.   Scientific Reports

Development of liposomal pemetrexed for enhanced therapy against multidrug resistance mediated by ABCC5 in breast cancer

(2018) Fang Bai et al.   International Journal of Nanomedicine

Efficacy of combined icotinib and pemetrexed in EGFR mutant lung adenocarcinoma cell line xenografts

(2018) Jiadong Cui et al.   Thoracic Cancer

Modeling Physiological Events in 2D vs. 3D Cell Culture

(2017) Kayla Duval et al.   PHYSIOLOGY

Anti-Cancer Drug Validation: the Contribution of Tissue Engineered Models

(2017) Mariana R. Carvalho et al.   Stem Cell Reviews and Reports

Anti-Cancer Drug Validation: the Contribution of Tissue Engineered Models

(2017) Mariana R. Carvalho et al.   Stem Cell Reviews and Reports

Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy

(2015) Q Tan et al.   BRITISH JOURNAL OF CANCER

Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer

(2015) YOSHINORI IMAMURA et al.   ONCOLOGY REPORTS

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Trastuzumab emtansine: mechanisms of action and drug resistance

(2014) Mark Barok et al.   BREAST CANCER RESEARCH

Anti-tumor activity of three ginsenoside derivatives in lung cancer is associated with Wnt/β-catenin signaling inhibition

(2014) Xiuli Bi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

3D Cell Culture Systems: Advantages and Applications

(2014) Maddaly Ravi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MMP-2/9-oriented combinations enhance antitumor efficacy of EGFR/HER2-targeting fusion proteins and gemcitabine

(2014) YE QIN et al.   ONCOLOGY REPORTS

3-Dimensional Culture Systems for Anti-Cancer Compound Profiling and High-Throughput Screening Reveal Increases in EGFR Inhibitor-Mediated Cytotoxicity Compared to Monolayer Culture Systems

(2014) Amy L. Howes et al.   PLoS One

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

(2014) Debangshu Samanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paclitaxel-incorporated nanoparticles using block copolymers composed of poly(ethylene glycol)/poly(3-hydroxyoctanoate)

(2014) Hyun Kim et al.   Nanoscale Research Letters

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

(2013) Paola Longati et al.   BMC CANCER

Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition

(2013) Michael Amatangelo et al.   CELL CYCLE

Arginine-stabilized mPEG-PDLLA (50/50) polymeric micelles of docetaxel by electrostatic mechanism for tumor-targeted delivery

(2013) Jifeng Shi et al.   DRUG DELIVERY

TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules

(2012) Qian Liu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Three-dimensional tissue cultures: current trends and beyond

(2012) Henry Page et al.   CELL AND TISSUE RESEARCH

GDC-0941, a Novel Class I Selective PI3K Inhibitor, Enhances the Efficacy of Docetaxel in Human Breast Cancer Models by Increasing Cell Death In Vitro and In Vivo

(2012) J. J. Wallin et al.   CLINICAL CANCER RESEARCH

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models

(2012) David A. Proia et al.   INVESTIGATIONAL NEW DRUGS

Mechanism of the Mesenchymal-Epithelial Transition and Its Relationship with Metastatic Tumor Formation

(2011) D. Yao et al.   MOLECULAR CANCER RESEARCH

Activity of Anticancer Agents in a Three-Dimensional Cell Culture Model

(2010) Victor Sanjit Nirmalanandhan et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Multiple uses of basement membrane-like matrix (BME/Matrigel) in vitro and in vivo with cancer cells

(2010) Gabriel Benton et al.   INTERNATIONAL JOURNAL OF CANCER

Suppression of Hypoxia-Inducible Factor 1α (HIF-1α) by Tirapazamine Is Dependent on eIF2α Phosphorylation Rather Than the mTORC1/4E-BP1 Pathway

(2010) Jun Zhang et al.   PLoS One

HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

(2009) Britta Weigelt et al.   BREAST CANCER RESEARCH AND TREATMENT

Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers

(2009) E. Izbicka et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Suppression of N-Ras by shRNA-expressing plasmid increases sensitivity of HepG2 cells to vincristine-induced growth inhibition

(2009) H-x Sun et al.   CANCER GENE THERAPY

An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models

(2008) Udai Banerji et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

3D cell culture opens new dimensions in cell-based assays

(2008) Bradley A. Justice et al.   DRUG DISCOVERY TODAY