Transcriptional regulation and drug resistance in Mycobacterium tuberculosis

Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis

(2022) Joshua M. Thiede et al.   mBio

Molecular Determinants of Ethionamide Resistance in Clinical Isolates of Mycobacterium tuberculosis

(2022) Anastasia Ushtanit et al.   Antibiotics-Basel

A Feedback Regulatory Loop Containing McdR and WhiB2 Controls Cell Division and DNA Repair in Mycobacteria

(2022) Wei Zhou et al.   mBio

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

(2022) Shuqi Li et al.   Nature Microbiology

Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms

(2022)   PLOS BIOLOGY

Deficiency of GntR Family Regulator MSMEG_5174 Promotes Mycobacterium smegmatis Resistance to Aminoglycosides via Manipulating Purine Metabolism

(2022) Wanyan Deng et al.   Frontiers in Microbiology

Riboswitches as Drug Targets for Antibiotics

(2021) Vipul Panchal et al.   Antibiotics-Basel

The role of epistasis in amikacin, kanamycin, bedaquiline, and clofazimine resistance in Mycobacterium tuberculosis complex

(2021) Roger Vargas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7

(2021) Mirjana Lilic et al.   MOLECULAR CELL

The Transcription Factor Rv1453 Regulates the Expression of qor and Confers Resistant to Clofazimine in Mycobacterium tuberculosis

(2021) Yuanyuan Li et al.   Infection and Drug Resistance

Collateral Sensitivity to β-Lactam Drugs in Drug-Resistant Tuberculosis Is Driven by the Transcriptional Wiring of BlaI Operon Genes

(2021) A. S. Trigos et al.   mSphere

Multiform antimicrobial resistance from a metabolic mutation

(2021) Sarah M. Schrader et al.   Science Advances

Intragenic Distribution of IS 6110 in Clinical Mycobacterium tuberculosis Strains: Bioinformatic Evidence for Gene Disruption Leading to Underdiagnosed Antibiotic Resistance

(2021) Rudy Antoine et al.   Microbiology Spectrum

Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates

(2021) Fatemeh Shahi et al.   Heliyon

Mathematical modelling of SigE regulatory network reveals new insights into bistability of mycobacterial stress response

(2021) Irene Zorzan et al.   BMC BIOINFORMATICS

Application of Computational Methods in Understanding Mutations in Mycobacterium tuberculosis Drug Resistance

(2021) Grace Mugumbate et al.   Frontiers in Molecular Biosciences

A landscape of genomic alterations at the root of a near-untreatable tuberculosis epidemic

(2020) Marisa Klopper et al.   BMC Medicine

Using genomics to understand the origin and dispersion of multidrug and extensively drug resistant tuberculosis in Portugal

(2020) João Perdigão et al.   Scientific Reports

Ectopic Expression of Rv0023 Mediates Isoniazid/Ethionamide Tolerance via Altering NADH/NAD+ Levels in Mycobacterium smegmatis

(2020) Shailesh Kumar Gupta et al.   Frontiers in Microbiology

Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid

(2020) Suha Kadura et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Real-Time Single-Cell Imaging Reveals Accelerating Lipid Peroxyl Radical Formation in Escherichia coli Triggered by a Fluoroquinolone Antibiotic

(2020) Sol R. Martínez et al.   ACS Infectious Diseases

Role of post‐translational modifications in the acquisition of drug resistance in Mycobacterium tuberculosis

(2020) Gunjan Arora et al.   FEBS Journal

Lineage-Specific Proteomic Signatures in the Mycobacterium tuberculosis Complex Reveal Differential Abundance of Proteins Involved in Virulence, DNA Repair, CRISPR-Cas, Bioenergetics and Lipid Metabolism

(2020) Solomon Abebe Yimer et al.   Frontiers in Microbiology

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

(2020) Jared S. Mackenzie et al.   Nature Communications

Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis

(2020) Nathan D. Hicks et al.   PLoS Pathogens

Mutations in Efflux Pump Rv1258c (Tap) Cause Resistance to Pyrazinamide, Isoniazid, and Streptomycin in M. tuberculosis

(2019) Jiayun Liu et al.   Frontiers in Microbiology

GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions

(2019) Maha R. Farhat et al.   Nature Communications

Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor

(2019) Su Tang et al.   NUCLEIC ACIDS RESEARCH

Reductive stress: new insights in physiology and drug tolerance of Mycobacterium

(2019) Parminder Singh Mavi et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the transcriptional regulator Lsr2 at threonine 112

(2019) Kawther Alqaseer et al.   MOLECULAR MICROBIOLOGY

Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex

(2019) Álvaro Chiner-Oms et al.   Nature Communications

Cell-wall synthesis and ribosome maturation are co-regulated by an RNA switch in Mycobacterium tuberculosis

(2018) Stefan Schwenk et al.   NUCLEIC ACIDS RESEARCH

Maestro of regulation: Riboswitches orchestrate gene expression at the levels of translation, transcription and mRNA decay

(2018) Laurène Bastet et al.   RNA Biology

Gene expression models based on a reference laboratory strain are poor predictors of Mycobacterium tuberculosis complex transcriptional diversity

(2018) Álvaro Chiner-Oms et al.   Scientific Reports

Delamanid, Bedaquiline, and Linezolid Minimum Inhibitory Concentration Distributions and Resistance-related Gene Mutations in Multidrug-resistant and Extensively Drug-resistant Tuberculosis in Korea

(2018) Jeong Seong Yang et al.   Annals of Laboratory Medicine

Regulatory RNA in Mycobacterium tuberculosis, back to basics

(2018) Stefan Schwenk et al.   Pathogens and Disease

In vivo evolution of drug-resistant Mycobacterium tuberculosis in patients during long-term treatment

(2018) Yuhui Xu et al.   BMC GENOMICS

Molecular mechanism of the synergistic activity of ethambutol and isoniazid against Mycobacterium tuberculosis

(2018) Chen Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Actinobacterial WhiB-like (Wbl) Family of Transcription Factors

(2018) Matthew J. Bush   MOLECULAR MICROBIOLOGY

Integrated analysis of ethionamide resistance loci in Mycobacterium tuberculosis clinical isolates

(2018) Duanne Alves da Silva et al.   TUBERCULOSIS

Mycobacterial Cell Wall Synthesis Inhibitors Cause Lethal ATP Burst

(2018) Annanya Shetty et al.   Frontiers in Microbiology

Clinically prevalent mutations in Mycobacterium tuberculosis alter propionate metabolism and mediate multidrug tolerance

(2018) Nathan D. Hicks et al.   Nature Microbiology

Mycobacterium tuberculosis Rv1473 is a novel macrolides ABC Efflux Pump regulated by WhiB7

(2018) Wei Duan et al.   Future Microbiology

The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis

(2017) Leonardo Astolfi Rosado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mycobacterium tuberculosis virulence-regulator PhoP interacts with alternative sigma factor SigE during acid-stress response

(2017) Roohi Bansal et al.   MOLECULAR MICROBIOLOGY

Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose

(2017) Maikel Boot et al.   PLoS Genetics

Roles of Regulatory RNAs for Antibiotic Resistance in Bacteria and Their Potential Value as Novel Drug Targets

(2017) Petra Dersch et al.   Frontiers in Microbiology

Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis

(2017) Yun-Rong Gao et al.   Scientific Reports

N-methylation of a bactericidal compound as a resistance mechanism inMycobacterium tuberculosis

(2016) Thulasi Warrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria

(2016) D. Dar et al.   SCIENCE

Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis

(2016) Vikram Saini et al.   Cell Reports

Network analysis identifies Rv0324 and Rv0880 as regulators of bedaquiline tolerance in Mycobacterium tuberculosis

(2016) Eliza J. R. Peterson et al.   Nature Microbiology

Mycobacterium tuberculosis Rv1152 is a Novel GntR Family Transcriptional Regulator Involved in Intrinsic Vancomycin Resistance and is a Potential Vancomycin Adjuvant Target

(2016) Jie Zeng et al.   Scientific Reports

Mutation ofRv2887, amarR-Like Gene, Confers Mycobacterium tuberculosis Resistance to an Imidazopyridine-Based Agent

(2015) Kathryn Winglee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Global analyses of TetR family transcriptional regulators in mycobacteria indicates conservation across species and diversity in regulated functions

(2015) Ricardo J. C. Balhana et al.   BMC GENOMICS

A GntR family transcription factor positively regulates mycobacterial isoniazid resistance by controlling the expression of a putative permease

(2015) Jialing Hu et al.   BMC MICROBIOLOGY

The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053

(2015) David Albesa-Jové et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Regulation of the MmpL Transporters ofMycobacterium tuberculosis

(2015) Jared A. Delmar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Ergothioneine Biosynthesis and Its Effect onMycobacterium tuberculosisGrowth and Infectivity

(2015) Melissa Richard-Greenblatt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptidoglycan synthesis inMycobacterium tuberculosisis organized into networks with varying drug susceptibility

(2015) Karen J. Kieser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of theMycobacterium tuberculosistranscriptional regulator Rv0302

(2015) Tsung-Han Chou et al.   PROTEIN SCIENCE

Within patient microevolution of Mycobacterium tuberculosis correlates with heterogeneous responses to treatment

(2015) Qingyun Liu et al.   Scientific Reports

Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria

(2015) Karen J. Kieser et al.   PLoS Pathogens

GntR Family of Bacterial Transcription Factors and Their DNA Binding Motifs: Structure, Positioning and Co-Evolution

(2015) Inna A. Suvorova et al.   PLoS One

Rifampin Induces Hydroxyl Radical Formation in Mycobacterium tuberculosis

(2014) Giovanni Piccaro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline

(2014) Koen Andries et al.   PLoS One

Crystal structure of the transcriptional regulator Rv1219c ofMycobacterium tuberculosis

(2014) Nitin Kumar et al.   PROTEIN SCIENCE

Global Adaptation to a Lipid Environment Triggers the Dormancy-Related Phenotype of Mycobacterium tuberculosis

(2014) J. G. Rodriguez et al.   mBio

Consequences ofwhiB7(Rv3197A) Mutations in Beijing Genotype Isolates of the Mycobacterium tuberculosis Complex

(2013) Claudio U. Köser et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aminoglycoside Cross-Resistance in Mycobacterium tuberculosis Due to Mutations in the 5′ Untranslated Region ofwhiB7

(2013) Analise Z. Reeves et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The promise of riboswitches as potential antibacterial drug targets

(2013) Christina E. Lünse et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

WhiB7, an Fe-S-dependent Transcription Factor That Activates Species-specific Repertoires of Drug Resistance Determinants in Actinobacteria

(2013) Santiago Ramón-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Riboswitches in eubacteria sense the second messenger c-di-AMP

(2013) James W Nelson et al.   Nature Chemical Biology

Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis

(2013) Maha R Farhat et al.   NATURE GENETICS

The mycobacterial antibiotic resistance determinant WhiB7 acts as a transcriptional activator by binding the primary sigma factor SigA (RpoV)

(2013) Ján Burian et al.   NUCLEIC ACIDS RESEARCH

Global Transcriptional Profiling of Longitudinal Clinical Isolates of Mycobacterium tuberculosis Exhibiting Rapid Accumulation of Drug Resistance

(2013) Anirvan Chatterjee et al.   PLoS One

Functional and Genetic Characterization of the Tap Efflux Pump in Mycobacterium bovis BCG

(2012) Santiago Ramón-García et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Importance of the Genetic Diversity within the Mycobacterium tuberculosis Complex for the Development of Novel Antibiotics and Diagnostic Tests of Drug Resistance

(2012) Claudio U. Köser et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Expression of ABC Efflux Pump, Rv1217c–Rv1218c, and Its Association with Multidrug Resistance of Mycobacterium tuberculosis in China

(2012) Ke Wang et al.   CURRENT MICROBIOLOGY

WhiB7, a transcriptional activator that coordinates physiology with intrinsic drug resistance inMycobacterium tuberculosis

(2012) Ján Burian et al.   Expert Review of Anti-Infective Therapy

A Copper-responsive Global Repressor Regulates Expression of Diverse Membrane-associated Transporters and Bacterial Drug Resistance in Mycobacteria

(2012) Muding Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Mechanism of Growth Phase-dependent Tolerance to Isoniazid in Mycobacteria

(2012) Makoto Niki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Novel N-Phenylphenoxyacetamide Derivatives as EthR Inhibitors and Ethionamide Boosters by Combining High-Throughput Screening and Synthesis

(2012) Marion Flipo et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel F420-dependent anti-oxidant mechanism protectsMycobacterium tuberculosisagainst oxidative stress and bactericidal agents

(2012) Meera Gurumurthy et al.   MOLECULAR MICROBIOLOGY

Structural and functional analysis of the transcriptional regulator Rv3066 of Mycobacterium tuberculosis

(2012) Jani Reddy Bolla et al.   NUCLEIC ACIDS RESEARCH

Characterization of a Novel ArsR-Like Regulator Encoded by Rv2034 in Mycobacterium tuberculosis

(2012) Chun-hui Gao et al.   PLoS One

Gene Expression of Mycobacterium tuberculosis Putative Transcription Factors whiB1-7 in Redox Environments

(2012) Christer Larsson et al.   PLoS One

Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7

(2012) K. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-coding RNA and its potential role in Mycobacterium tuberculosis pathogenesis

(2012) Kristine Arnvig et al.   RNA Biology

Isoniazid resistance without a loss of fitness in Mycobacterium tuberculosis

(2012) Jong-Hee Lee et al.   Nature Communications

Riboswitches: Discovery of Drugs That Target Bacterial Gene-Regulatory RNAs

(2011) Katherine E. Deigan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Precise Null Deletion Mutations of the Mycothiol Synthesis Genes Reveal Their Role in Isoniazid and Ethionamide Resistance in Mycobacterium smegmatis

(2011) Xia Xu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

Sigma Factor F Does Not Prevent Rifampin Inhibition of RNA Polymerase or Cause Rifampin Tolerance in Mycobacterium tuberculosis

(2010) R. C. Hartkoorn et al.   JOURNAL OF BACTERIOLOGY

Functional Genetic Diversity among Mycobacterium tuberculosis Complex Clinical Isolates: Delineation of Conserved Core and Lineage-Specific Transcriptomes during Intracellular Survival

(2010) Susanne Homolka et al.   PLoS Pathogens

Global transcriptional response to vancomycin in Mycobacterium tuberculosis

(2009) R. Provvedi et al.   MICROBIOLOGY-SGM

An integrated regulatory network including two positive feedback loops to modulate the activity of σEin mycobacteria

(2009) Riccardo Manganelli et al.   MOLECULAR MICROBIOLOGY

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

(2009) Nicolas Willand et al.   NATURE MEDICINE

Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis

(2009) M. A. Zaunbrecher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of promoter-binding proteins of the fbp A and C genes in Mycobacterium tuberculosis

(2009) Ibeth C. Romero et al.   TUBERCULOSIS

The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest

(2008) Gábor Balázsi et al.   Molecular Systems Biology

Positive Feedback and Noise Activate the Stringent Response Regulator Rel in Mycobacteria

(2008) Kamakshi Sureka et al.   PLoS One

Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5–MmpL5 efflux system

(2008) Anna Milano et al.   TUBERCULOSIS