Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms

Bedaquiline-resistant Tuberculosis: Dark Clouds on the Horizon

(2020) Sönke Andres et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Early Bactericidal Activity of Different Isoniazid Doses for Drug Resistant TB (INHindsight): A Randomized Open-label Clinical Trial

(2020) Kelly E Dooley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

High-dose First-line Treatment Regimen for Recurrent Rifampicin-susceptible Tuberculosis

(2020) Tom Decroo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid

(2020) Suha Kadura et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mechanisms of Drug-Induced Tolerance in Mycobacterium tuberculosis

(2020) Sander N. Goossens et al.   CLINICAL MICROBIOLOGY REVIEWS

Emergence of low level delamanid and bedaquiline resistance during extremely drug resistant tuberculosis treatment

(2019) S Polsfuss et al.   CLINICAL INFECTIOUS DISEASES

Improved Outcomes with High-Dose Isoniazid in Multidrug-Resistant Tuberculosis Treatment in Haiti

(2019) Kathleen F Walsh et al.   CLINICAL INFECTIOUS DISEASES

Genome-wide analysis of Mycobacterium tuberculosis polymorphisms reveals lineage-specific associations with drug resistance

(2019) Yaa E. A. Oppong et al.   BMC GENOMICS

New WHO Treatment Recommendations for Multidrug-Resistant Tuberculosis: Are We Well Enough Prepared?

(2019) Katharina Kranzer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bacterial Genome-Wide Association Identifies Novel Factors That Contribute to Ethionamide and Prothionamide Susceptibility in Mycobacterium tuberculosis

(2019) Nathan D. Hicks et al.   mBio

Assessing capreomycin resistance on tlyA deficient and point mutation (G695A) Mycobacterium tuberculosis strains using multi-omics analysis

(2019) Jiao Zhao et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Mycobacterium tuberculosis CysA2 is a dual sulfurtransferase with activity against thiosulfate and 3-mercaptopyruvate and interacts with mammalian cells

(2019) A. N. Meza et al.   Scientific Reports

Validating a 14-drug microtitre plate containing bedaquiline and delamanid for large-scale research susceptibility testing of Mycobacterium tuberculosis

(2018) Paola M. V. Rancoita et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis

(2018) Francesc Coll et al.   NATURE GENETICS

Bacterial Factors That Predict Relapse after Tuberculosis Therapy

(2018) Roberto Colangeli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Outbreak of multidrug-resistant tuberculosis in South Africa undetected by WHO-endorsed commercial tests: an observational study

(2018) Ndivhuho A Makhado et al.   LANCET INFECTIOUS DISEASES

A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis

(2017) Paolo Miotto et al.   EUROPEAN RESPIRATORY JOURNAL

Crystal structure of Mycobacterium tuberculosis VapC20 toxin and its interactions with cognate antitoxin, VapB20, suggest a model for toxin-antitoxin assembly

(2017) Amar Deep et al.   FEBS Journal

Drug resistance mechanisms and novel drug targets for tuberculosis therapy

(2017) Md Mahmudul Islam et al.   Journal of Genetics and Genomics

Tuberculosis is changing

(2017) Timothy M Walker et al.   LANCET INFECTIOUS DISEASES

Transmission of Extensively Drug-Resistant Tuberculosis in South Africa

(2017) N. Sarita Shah et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Determinants of Drug Resistance inMycobacterium tuberculosisand Their Diagnostic Value

(2016) Maha R. Farhat et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role ofgyrBMutations in Pre-extensively and Extensively Drug-Resistant Tuberculosis in Thai Clinical Isolates

(2016) Areeya Disratthakit et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Gyrase Mutations Are Associated with Variable Levels of Fluoroquinolone Resistance in Mycobacterium tuberculosis

(2016) Maha R. Farhat et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Rapid, comprehensive, and affordable mycobacterial diagnosis with whole-genome sequencing: a prospective study

(2016) Louise J Pankhurst et al.   Lancet Respiratory Medicine

Identifying lineage effects when controlling for population structure improves power in bacterial association studies

(2016) Sarah G. Earle et al.   Nature Microbiology

Using a Label Free Quantitative Proteomics Approach to Identify Changes in Protein Abundance in Multidrug-Resistant Mycobacterium tuberculosis

(2015) Truong Quoc Phong et al.   INDIAN JOURNAL OF MICROBIOLOGY

Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study

(2015) Timothy M Walker et al.   LANCET INFECTIOUS DISEASES

Detection of Drug-Resistant Tuberculosis by Xpert MTB/RIF in Swaziland

(2015) Elisabeth Sanchez-Padilla et al.   NEW ENGLAND JOURNAL OF MEDICINE

The interaction of mycobacterial protein Rv2966c with host chromatin is mediated through non-CpG methylation and histone H3/H4 binding

(2015) Garima Sharma et al.   NUCLEIC ACIDS RESEARCH

Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis

(2015) Phelim Bradley et al.   Nature Communications

Profiling of rpoB Mutations and MICs for Rifampin and Rifabutin in Mycobacterium tuberculosis

(2014) F. B. Jamieson et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Crystal structure of the transcriptional regulator Rv1219c ofMycobacterium tuberculosis

(2014) Nitin Kumar et al.   PROTEIN SCIENCE

Aminoglycoside Cross-Resistance in Mycobacterium tuberculosis Due to Mutations in the 5′ Untranslated Region ofwhiB7

(2013) Analise Z. Reeves et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

DSK: k-mer counting with very low memory usage

(2013) G. Rizk et al.   BIOINFORMATICS

A highly conserved mycobacterial cholesterol catabolic pathway

(2013) Esther García-Fernández et al.   ENVIRONMENTAL MICROBIOLOGY

WhiB7, an Fe-S-dependent Transcription Factor That Activates Species-specific Repertoires of Drug Resistance Determinants in Actinobacteria

(2013) Santiago Ramón-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis

(2013) Maha R Farhat et al.   NATURE GENETICS

Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance

(2013) Hongtai Zhang et al.   NATURE GENETICS

The Rationale for Using Rifabutin in the Treatment of MDR and XDR Tuberculosis Outbreaks

(2013) Frederick A. Sirgel et al.   PLoS One

VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA

(2013) Kristoffer S. Winther et al.   Nature Communications

Extending the Definition of the GyrB Quinolone Resistance-Determining Region in Mycobacterium tuberculosis DNA Gyrase for Assessing Fluoroquinolone Resistance in M. tuberculosis

(2012) Alix Pantel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Expression of ABC Efflux Pump, Rv1217c–Rv1218c, and Its Association with Multidrug Resistance of Mycobacterium tuberculosis in China

(2012) Ke Wang et al.   CURRENT MICROBIOLOGY

Structure of the Sensor Domain of Mycobacterium tuberculosis PknH Receptor Kinase Reveals a Conserved Binding Cleft

(2012) Alexandra Cavazos et al.   JOURNAL OF MOLECULAR BIOLOGY

Capreomycin susceptibility is increased by TlyA-directed 2′-O-methylation on both ribosomal subunits

(2012) Tanakarn Monshupanee et al.   MOLECULAR MICROBIOLOGY

Genome-wide efficient mixed-model analysis for association studies

(2012) Xiang Zhou et al.   NATURE GENETICS

New Insights into Fluoroquinolone Resistance in Mycobacterium tuberculosis: Functional Genetic Analysis of gyrA and gyrB Mutations

(2012) Seidu Malik et al.   PLoS One

Low-level rifampicin-resistant Mycobacterium tuberculosis strains raise a new therapeutic challenge [Short communication]

(2011) J. van Ingen et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

The Mycobacterial Transcriptional RegulatorwhiB7Gene Links Redox Homeostasis and Intrinsic Antibiotic Resistance

(2011) Ján Burian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study

(2011) Catharina C Boehme et al.   LANCET

Structural and Biochemical Characterization ofMycobacterium tuberculosisCYP142

(2010) Max D. Driscoll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase

(2010) Takahiro Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New approaches to population stratification in genome-wide association studies

(2010) Alkes L. Price et al.   NATURE REVIEWS GENETICS

Rapid Molecular Detection of Tuberculosis and Rifampin Resistance

(2010) Catharina C. Boehme et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reaction ofMycobacterium tuberculosisCytochrome P450 Enzymes with Nitric Oxide†

(2009) Hugues Ouellet et al.   BIOCHEMISTRY

Velvet: Algorithms for de novo short read assembly using de Bruijn graphs

(2008) D. R. Zerbino et al.   GENOME RESEARCH