Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid

Clofazimine exposure in vitro selects efflux pump mutants and bedaquiline resistance

(2019) Nabila Ismail et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

‘Those who cannot remember the past are condemned to repeat it’: Drug-susceptibility testing for bedaquiline and delamanid

(2019) Claudio U. Köser et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Standards for MIC testing that apply to the majority of bacterial pathogens should also be enforced for Mycobacterium tuberculosis complex

(2019) T. Schön et al.   CLINICAL MICROBIOLOGY AND INFECTION

GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions

(2019) Maha R. Farhat et al.   Nature Communications

Pretomanid: First Approval

(2019) Susan J. Keam   DRUGS

Mechanisms of resistance to delamanid, a drug for Mycobacterium tuberculosis

(2018) Mamoru Fujiwara et al.   TUBERCULOSIS

Mutations associated with in vitro resistance to bedaquiline in Mycobacterium tuberculosis isolates in Australia

(2018) Elena Martinez et al.   TUBERCULOSIS

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase

(2018) Matthew Ezewudo et al.   Scientific Reports

Examination of bedaquiline- and linezolid-resistant Mycobacterium tuberculosis isolates from the Moscow region

(2017) Danila V. Zimenkov et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis

(2017) Subramanyam J. Tantry et al.   JOURNAL OF MEDICINAL CHEMISTRY

Performance of TaqMan array card to detect TB drug resistance on direct specimens

(2017) Sayera Banu et al.   PLoS One

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis

(2017) Michael A. DeJesus et al.   mBio

Genetic Determinants of Drug Resistance inMycobacterium tuberculosisand Their Diagnostic Value

(2016) Maha R. Farhat et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Delamanid and Bedaquiline Resistance inMycobacterium tuberculosisAncestral Beijing Genotype Causing Extensively Drug-Resistant Tuberculosis in a Tibetan Refugee

(2016) Harald Hoffmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis

(2016) Gaëlle Guiewi Makafe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mycobacterium tuberculosis Mutations Associated with Reduced Susceptibility to Linezolid

(2016) Shuo Zhang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mutations inpepQConfer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis

(2016) Deepak Almeida et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rapid emergence ofMycobacterium tuberculosisbedaquiline resistance: lessons to avoid repeating past errors

(2016) Nicolas Veziris et al.   EUROPEAN RESPIRATORY JOURNAL

Beyond extensively drug-resistant tuberculosis in Lisbon, Portugal: a case of linezolid resistance acquisition presenting as an iliopsoas abscess

(2016) João Perdigão et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Delamanid susceptibility testing ofMycobacterium tuberculosisusing the resazurin microtitre assay and the BACTEC™ MGIT™ 960 system

(2016) Elisa Schena et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway

(2016) Subramanyam J. Tantry et al.   MedChemComm

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

(2016) Dirk A. Lamprecht et al.   Nature Communications

Mutations in Genes for the F420Biosynthetic Pathway and a Nitroreductase Enzyme Are the Primary Resistance Determinants in SpontaneousIn Vitro-Selected PA-824-Resistant Mutants of Mycobacterium tuberculosis

(2015) Hana L. Haver et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bedaquiline susceptibility testing ofMycobacterium tuberculosisin an automated liquid culture system

(2015) Gabriela Torrea et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Identification of novel mutations associated with clofazimine resistance inMycobacterium tuberculosis: Table 1.

(2015) Shuo Zhang et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Drug-resistance mechanisms and tuberculosis drugs

(2015) Claudio U Köser et al.   LANCET

Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis

(2015) Guido V. Bloemberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis

(2014) R. C. Hartkoorn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A mutation associated with clofazimine and bedaquiline cross-resistance in MDR-TB following bedaquiline treatment: TABLE 1

(2014) Akos Somoskovi et al.   EUROPEAN RESPIRATORY JOURNAL

Beijing genotype of Mycobacterium tuberculosis is significantly associated with linezolid resistance in multidrug-resistant and extensively drug-resistant tuberculosis in China

(2014) Zhijian Zhang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline

(2014) Koen Andries et al.   PLoS One

Pilon: An Integrated Tool for Comprehensive Microbial Variant Detection and Genome Assembly Improvement

(2014) Bruce J. Walker et al.   PLoS One

A robust SNP barcode for typing Mycobacterium tuberculosis complex strains

(2014) Francesc Coll et al.   Nature Communications

Kraken: ultrafast metagenomic sequence classification using exact alignments

(2014) Derrick E Wood et al.   GENOME BIOLOGY

Bactericidal Activity and Mechanism of Action of AZD5847, a Novel Oxazolidinone for Treatment of Tuberculosis

(2013) V. Balasubramanian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis

(2013) H. Nebenzahl-Guimaraes et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

New Mutations in the Mycobacterial ATP Synthase: New Insights into the Binding of the Diarylquinoline TMC207 to the ATP Synthase C-Ring Structure

(2012) Elena Segala et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

rplCT460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains

(2012) Patrick Beckert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Delamanid for Multidrug-Resistant Pulmonary Tuberculosis

(2012) Maria Tarcela Gler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis

(2012) Myungsun Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impact offgd1andddnDiversity in Mycobacterium tuberculosis Complex onIn VitroSusceptibility to PA-824

(2011) Silke Feuerriegel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quality control and preprocessing of metagenomic datasets

(2011) R. Schmieder et al.   BIOINFORMATICS

The ins and outs of Mycobacterium tuberculosis drug susceptibility testing

(2011) E.C. Böttger   CLINICAL MICROBIOLOGY AND INFECTION

Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles

(2011) Meera Gurumurthy et al.   FEBS Journal

Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase

(2010) Takahiro Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rates and Mechanisms of Resistance Development in Mycobacterium tuberculosis to a Novel Diarylquinoline ATP Synthase Inhibitor

(2009) E. Huitric et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Linezolid in the Treatment of Multidrug‐Resistant Tuberculosis

(2009) G. F. Schecter et al.   CLINICAL INFECTIOUS DISEASES

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

(2009) Andreas H. Diacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents

(2008) J. G. Hurdle et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY