Metabolic flexibilities and vulnerabilities in the pentose phosphate pathway of the zoonotic pathogen Toxoplasma gondii

A single Na+-Pi cotransporter in Toxoplasma plays key roles in phosphate import and control of parasite osmoregulation

(2021) Beejan Asady et al.   PLoS Pathogens

Mitochondrial NADP(H) generation is essential for proline biosynthesis

(2021) Jiajun Zhu et al.   SCIENCE

Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma

(2020) Xiaohan Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptomic analyses reveal distinct response of porcine macrophages to Toxoplasma gondii infection

(2020) Jianmin Cui et al.   PARASITOLOGY RESEARCH

Dual metabolomic profiling uncovers Toxoplasma manipulation of the host metabolome and the discovery of a novel parasite metabolic capability

(2020) William J. Olson et al.   PLoS Pathogens

Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii

(2020) Bingjian Ren et al.   Communications Biology

IsoCor: isotope correction for high-resolution MS labeling experiments

(2019) Pierre Millard et al.   BIOINFORMATICS

Intestinal delta-6-desaturase activity determines host range for Toxoplasma sexual reproduction

(2019) Bruno Martorelli Di Genova et al.   PLOS BIOLOGY

Two-step derivatization for determination of sugar phosphates in plants by combined reversed phase chromatography/tandem mass spectrometry

(2019) Umut Rende et al.   Plant Methods

Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii

(2019) Alex Hunt et al.   eLife

γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

(2019) Xue Gao et al.   MOLECULAR CELL

Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids

(2018) Lena Pernas et al.   Cell Metabolism

Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii

(2018) Anurag Shukla et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii

(2018) Joseph D. Lykins et al.   Frontiers in Cellular and Infection Microbiology

Thioredoxin reductase from Toxoplasma gondii: an essential virulence effector with antioxidant function

(2017) Junxin Xue et al.   FASEB JOURNAL

A plant/fungal-type phosphoenolpyruvate carboxykinase located in the parasite mitochondrion ensures glucose-independent survival ofToxoplasma gondii

(2017) Richard Nitzsche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two phylogenetically and compartmentally distinct CDP-diacylglycerol synthases cooperate for lipid biogenesis in Toxoplasma gondii

(2017) Pengfei Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii

(2017) Sabrina J. Nolan et al.   PLoS Pathogens

ANK1 and DnaK-TPR, Two Tetratricopeptide Repeat-Containing Proteins Primarily Expressed in Toxoplasma Bradyzoites, Do Not Contribute to Bradyzoite Differentiation

(2017) Jichao Yang et al.   Frontiers in Microbiology

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

(2016) Saima M. Sidik et al.   CELL

The Pentose Phosphate Pathway in Parasitic Trypanosomatids

(2016) Julie Kovářová et al.   TRENDS IN PARASITOLOGY

SIRT2 activates G6PD to enhance NADPH production and promote leukaemia cell proliferation

(2016) Shuang-Nian Xu et al.   Scientific Reports

Metabolic Cooperation of Glucose and Glutamine Is Essential for the Lytic Cycle of Obligate Intracellular ParasiteToxoplasma gondii

(2015) Richard Nitzsche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells

(2015) Andreas Kuehne et al.   MOLECULAR CELL

Ribose 5-Phosphate Isomerase B Knockdown Compromises Trypanosoma brucei Bloodstream Form Infectivity

(2015) Inês Loureiro et al.   PLoS Neglected Tropical Diseases

Phosphatidylethanolamine Synthesis in the Parasite Mitochondrion Is Required for Efficient Growth but Dispensable for Survival ofToxoplasma gondii

(2014) Anne Hartmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

(2014) Caroline A. Lewis et al.   MOLECULAR CELL

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Toxoplasmaaldolase is required for metabolism but dispensable for host-cell invasion

(2014) Bang Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9

(2014) B. Shen et al.   mBio

BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei

(2014) Rebecca D. Oppenheim et al.   PLoS Pathogens

TAp73 enhances the pentose phosphate pathway and supports cell proliferation

(2013) Wenjing Du et al.   NATURE CELL BIOLOGY

Mitochondrial Metabolism of Glucose and Glutamine Is Required for Intracellular Growth of Toxoplasma gondii

(2012) James I. MacRae et al.   Cell Host & Microbe

Conditional Mutagenesis of a Novel Choline Kinase Demonstrates Plasticity of Phosphatidylcholine Biogenesis and Gene Expression inToxoplasma gondii

(2012) Vera Sampels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms

(2012) Nicole Andenmatten et al.   NATURE METHODS

Transcriptomic Analysis of Toxoplasma Development Reveals Many Novel Functions and Structures Specific to Sporozoites and Oocysts

(2012) Heather M. Fritz et al.   PLoS One

Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites

(2009) Artur T. Cordeiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A New G6PD Knockdown Tumor-Cell Line with Reduced Proliferation and Increased Susceptibility to Oxidative Stress

(2009) Danyi Li et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis

(2009) M. Blume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA