Toll-like receptors and their role in neuropathic pain and migraine

Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice

(2021) Wei-Jia Chen et al.   JOURNAL OF HEADACHE AND PAIN

A Framework for Estimating the Eligible Patient Population for New Migraine Acute Therapies in the United States

(2021) Linda Harris et al.   ADVANCES IN THERAPY

Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders

(2021) Michal Fila et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Migraine and neuroinflammation: the inflammasome perspective

(2021) Oguzhan Kursun et al.   JOURNAL OF HEADACHE AND PAIN

TLR and IKK Complex–Mediated Innate Immune Signaling Inhibits Stress Granule Assembly

(2021) Parimal Samir et al.   JOURNAL OF IMMUNOLOGY

GT 1b functions as a novel endogenous agonist of toll‐like receptor 2 inducing neuropathic pain

(2020) Hyoungsub Lim et al.   EMBO JOURNAL

Toll-like receptor 7 contributes to neuropathic pain by activating NF-κB in primary sensory neurons

(2020) Long He et al.   BRAIN BEHAVIOR AND IMMUNITY

Anti-inflammatory protein TSG-6 secreted by bone marrow mesenchymal stem cells attenuates neuropathic pain by inhibiting the TLR2/MyD88/NF-κB signaling pathway in spinal microglia

(2020) Hao Yang et al.   Journal of Neuroinflammation

Microglia-Astrocyte Cross Talk through IL-18/IL-18R Signaling Modulates Migraine-like Behavior in Experimental Models of Migraine

(2020) Qiaoyu Gong et al.   NEUROSCIENCE

Macrophage toll-like receptor 9 contributes to chemotherapy-induced neuropathic pain in male mice

(2019) Xin Luo et al.   JOURNAL OF NEUROSCIENCE

[EXPRESS] Role of Toll-like receptor 4 signaling in mast cell mediated trigeminal pain pathway.

(2019) Roshni Ramachandran et al.   Molecular Pain

Electroacupuncture Alleviates Paclitaxel-Induced Peripheral Neuropathic Pain in Rats via Suppressing TLR4 Signaling and TRPV1 Upregulation in Sensory Neurons

(2019) Yuanyuan Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toll and Toll-like receptor signalling in development

(2018) Niki Anthoney et al.   DEVELOPMENT

Inhibition of toll-like receptor 4 alleviates hyperalgesia induced by acute dural inflammation in experimental migraine

(2018) Min Su et al.   Molecular Pain

CGRP as the target of new migraine therapies — successful translation from bench to clinic

(2018) Lars Edvinsson et al.   Nature Reviews Neurology

Toll-like receptors and their role in persistent pain

(2018) Michael J. Lacagnina et al.   PHARMACOLOGY & THERAPEUTICS

TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG

(2018) Zhi-Jun Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Progression in migraine: Role of mast cells and pro-inflammatory and anti-inflammatory cytokines

(2018) Pio Conti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

E6020, a synthetic TLR4 agonist, accelerates myelin debris clearance, Schwann cell infiltration, and remyelination in the rat spinal cord

(2017) Jamie S. Church et al.   GLIA

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Theo Vos et al.   LANCET

Effects of Nigella sativa seeds and certain species of fungi extracts on number and activation of dural mast cells in rats

(2017) E Kilinc et al.   Physiology International

Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: Implications for extracranial origin of headache

(2016) Carlton J. Perry et al.   ANNALS OF NEUROLOGY

High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression

(2016) Tsubasa Takizawa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

TLR10 Is a Negative Regulator of Both MyD88-Dependent and -Independent TLR Signaling

(2016) Song Jiang et al.   JOURNAL OF IMMUNOLOGY

Upregulated TLR3 Promotes Neuropathic Pain by Regulating Autophagy in Rat With L5 Spinal Nerve Ligation Model

(2016) Weijia Chen et al.   NEUROCHEMICAL RESEARCH

Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade

(2015) Zhen-Zhong Xu et al.   NATURE MEDICINE

Cigarette Smoke Amplifies Inflammatory Response and Atherosclerosis Progression Through Activation of the H1R-TLR2/4-COX2 Axis

(2015) Rajat S. Barua et al.   Frontiers in Immunology

Toll-like receptors in central nervous system injury and disease: A focus on the spinal cord

(2014) Adee Heiman et al.   BRAIN BEHAVIOR AND IMMUNITY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Immunomodulatory Effect of Toll-Like Receptor-3 Ligand Poly I:C on Cortical Spreading Depression

(2014) Amir Ghaemi et al.   MOLECULAR NEUROBIOLOGY

Neuropathic Pain and Deep Brain Stimulation

(2014) Erlick A. C. Pereira et al.   Neurotherapeutics

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice

(2013) Jennifer A Stokes et al.   Journal of Neuroinflammation

Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels

(2013) H. Karatas et al.   SCIENCE

Toll-Like Receptor Signaling

(2013) K.-H. Lim et al.   Cold Spring Harbor Perspectives in Biology

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

(2012) Tong Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymphocyte subsets in pediatric migraine

(2012) Aron Cseh et al.   NEUROLOGICAL SCIENCES

MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

Emerging role of Toll-like receptors in the control of pain and itch

(2012) Tong Liu et al.   Neuroscience Bulletin

Toll-like receptors in chronic pain

(2011) Lauren Nicotra et al.   EXPERIMENTAL NEUROLOGY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Painful Pathways Induced by TLR Stimulation of Dorsal Root Ganglion Neurons

(2011) J. Qi et al.   JOURNAL OF IMMUNOLOGY

Ketamine Depresses Toll-Like Receptor 3 Signaling in Spinal Microglia in a Rat Model of Neuropathic Pain

(2011) Xiao-Peng Mei et al.   NEUROSIGNALS

Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis

(2011) Christina A. Christianson et al.   PAIN

A new definition of neuropathic pain

(2011) Troels S. Jensen et al.   PAIN

Localisation and trafficking of Toll-like receptors: an important mode of regulation

(2010) Anne F McGettrick et al.   CURRENT OPINION IN IMMUNOLOGY

The role of TLR2 in nerve injury-induced neuropathic pain is essentially mediated through macrophages in peripheral inflammatory response

(2010) Xiang Qun Shi et al.   GLIA

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

TLR2 activation inhibits embryonic neural progenitor cell proliferation

(2010) Eitan Okun et al.   JOURNAL OF NEUROCHEMISTRY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

(2010) J. A. Sloane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

(2009) Jin Young Kang et al.   IMMUNITY

Toll-Like Receptor 2-Independent and MyD88-Dependent Gene Expression in the Mouse Brain

(2009) Gaëlle Naert et al.   Journal of Innate Immunity

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

(2008) Mark R. Hutchinson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Toll-Like Receptor 3 Is a Negative Regulator of Embryonic Neural Progenitor Cell Proliferation

(2008) J. D. Lathia et al.   JOURNAL OF NEUROSCIENCE

Prevalence of chronic pain with neuropathic characteristics in the general population

(2007) Didier Bouhassira et al.   PAIN