TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG

The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development

(2018) Flávia V. Santa-Cecília et al.   PAIN

Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms

(2017) Rou-Gang Xie et al.   Neuroscience Bulletin

CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5

(2016) Bao-Chun Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice

(2016) Qian Zhang et al.   Journal of Neuroinflammation

Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice

(2016) Tong Liu et al.   PAIN

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

(2016) Peter M. Grace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain

(2016) Xiao-Bo Wu et al.   Scientific Reports

Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA

(2015) A. Kru ger et al.   EMBO REPORTS

TLR8 SensesStaphylococcus aureusRNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1–IKKβ–IRF5 Signaling Pathway

(2015) Bjarte Bergstrøm et al.   JOURNAL OF IMMUNOLOGY

The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4

(2015) Y. Li et al.   JOURNAL OF NEUROSCIENCE

Neuroimmune interactions in itch: Do chronic itch, chronic pain, and chronic cough share similar mechanisms?

(2015) Ru-Rong Ji   PULMONARY PHARMACOLOGY & THERAPEUTICS

A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief

(2014) Jun-Ho Lee et al.   CELL

Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion

(2014) Temugin Berta et al.   JOURNAL OF CLINICAL INVESTIGATION

Endosomal Localization of TLR8 Confers Distinctive Proteolytic Processing on Human Myeloid Cells

(2014) Noriko Ishii et al.   JOURNAL OF IMMUNOLOGY

Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1

(2014) Chul-Kyu Park et al.   NEURON

Nerve injury-induced upregulation of miR-21 in the primary sensory neurons contributes to neuropathic pain in rats

(2013) Atsushi Sakai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-7a alleviates the maintenance of neuropathic pain through regulation of neuronal excitability

(2013) Atsushi Sakai et al.   BRAIN

Chemokine contribution to neuropathic pain: Respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons

(2013) Zhi-Jun Zhang et al.   PAIN

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

(2013) H. Tanji et al.   SCIENCE

UNC93B1 mediates differential trafficking of endosomal TLRs

(2013) Bettina L Lee et al.   eLife

Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain

(2012) Fei-xiang Wu et al.   International Journal of Medical Sciences

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

(2012) Tong Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Toll-Like Receptor 8 Can Be Cool Too: Implications for Foreign RNA Sensing

(2012) Soroush T. Sarvestani et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

TRPA1 Is Functionally Expressed Primarily by IB4-Binding, Non-Peptidergic Mouse and Rat Sensory Neurons

(2012) Marie E. Barabas et al.   PLoS One

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging role of Toll-like receptors in the control of pain and itch

(2012) Tong Liu et al.   Neuroscience Bulletin

VTX-2337 Is a Novel TLR8 Agonist That Activates NK Cells and Augments ADCC

(2011) H. Lu et al.   CLINICAL CANCER RESEARCH

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Painful Pathways Induced by TLR Stimulation of Dorsal Root Ganglion Neurons

(2011) J. Qi et al.   JOURNAL OF IMMUNOLOGY

Long-term IL-1β exposure causes subpopulation-dependent alterations in rat dorsal root ganglion neuron excitability

(2011) Patrick L. Stemkowski et al.   JOURNAL OF NEUROPHYSIOLOGY

The Chemokine CCL2 Increases Nav1.8 Sodium Channel Activity in Primary Sensory Neurons through a G  -Dependent Mechanism

(2011) M. Belkouch et al.   JOURNAL OF NEUROSCIENCE

Identification and functional analysis of novel micro-rnas in rat dorsal root ganglia after sciatic nerve resection

(2011) Shiying Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis

(2011) Christina A. Christianson et al.   PAIN

Axotomy-Induced miR-21 Promotes Axon Growth in Adult Dorsal Root Ganglion Neurons

(2011) Iain T. Strickland et al.   PLoS One

UNC93B1 Physically Associates with Human TLR8 and Regulates TLR8-Mediated Signaling

(2011) Hiroki Itoh et al.   PLoS One

TLR8 deficiency leads to autoimmunity in mice

(2010) Olivier Demaria et al.   JOURNAL OF CLINICAL INVESTIGATION

ERK1/2 Mitogen-Activated Protein Kinase Phosphorylates Sodium Channel Nav1.7 and Alters Its Gating Properties

(2010) S. Stamboulian et al.   JOURNAL OF NEUROSCIENCE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Toll-like receptor 7 mediates pruritus

(2010) Tong Liu et al.   NATURE NEUROSCIENCE

Targeting astrocyte signaling for chronic pain

(2010) Yong-Jing Gao et al.   Neurotherapeutics

Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA

(2010) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

(2009) Y.-J. Gao et al.   JOURNAL OF NEUROSCIENCE

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAP kinase and pain

(2008) Ru-Rong Ji et al.   BRAIN RESEARCH REVIEWS

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE

EphrinB-EphB receptor signaling contributes to neuropathic pain by regulating neural excitability and spinal synaptic plasticity in rats

(2008) Xue-Jun Song et al.   PAIN