The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms
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Title
The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms
Authors
Keywords
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Journal
Cell Death & Disease
Volume 13, Issue 10, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-10-07
DOI
10.1038/s41419-022-05268-9
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Note: Only part of the references are listed.- m6A binding protein YTHDF2 in cancer
- (2022) Xiaomin Chen et al. Experimental Hematology & Oncology
- The emerging roles of RNA m6A methylation and demethylation as critical regulators of tumorigenesis, drug sensitivity, and resistance
- (2021) Qing Lan et al. CANCER RESEARCH
- WTAP facilitates progression of endometrial cancer via CAV‐1/NF‐κB axis
- (2021) Qin Li et al. CELL BIOLOGY INTERNATIONAL
- RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent
- (2021) Xin Wang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Wilms’ Tumor 1-Associated Protein Contributes to Chemo-Resistance to Cisplatin Through the Wnt/β-Catenin Pathway in Endometrial Cancer
- (2021) Wenli Xie et al. Frontiers in Oncology
- USP48 is upregulated by Mettl14 to attenuate hepatocellular carcinoma via regulating SIRT6 stabilization
- (2021) Lutao Du et al. CANCER RESEARCH
- Degradation of WTAP blocks antiviral responses by reducing the m 6 A levels of IRF3 and IFNAR1 mRNA
- (2021) Yong Ge et al. EMBO REPORTS
- Loss of WTAP Impairs Early Parthenogenetic Embryo Development
- (2021) Jindong Hao et al. Animals
- The RNA m6A writer METTL14 in cancers: Roles, structures, and applications
- (2021) Huimin Zhou et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Wilms’ tumor 1-associating protein complex regulates alternative splicing and polyadenylation at potential G-quadruplex-forming splice site sequences
- (2021) Keiko Horiuchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells
- (2020) Yabing Chen et al. Autophagy
- Epigenetics/Epigenomics of Triterpenoids in Cancer Prevention and in Health
- (2020) Shanyi Li et al. BIOCHEMICAL PHARMACOLOGY
- METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST
- (2020) Xiao Yang et al. Molecular Cancer
- The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation
- (2020) Tao Liu et al. NUCLEIC ACIDS RESEARCH
- N 6 ‐methyladenosine Reader Protein Ythdc2 Suppresses Liver Steatosis via Regulation of mRNA Stability of Lipogenic Genes
- (2020) Bing Zhou et al. HEPATOLOGY
- RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner
- (2020) Xingya Guo et al. Molecular Cancer
- The potential role of RNA N6-methyladenosine in Cancer progression
- (2020) Tianyi Wang et al. Molecular Cancer
- METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer
- (2020) Xiaoxiang Chen et al. Molecular Cancer
- METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation
- (2020) Canfeng Zhang et al. MOLECULAR CELL
- The Contribution of Epigenetics to Cancer Immunotherapy
- (2020) Lorea Villanueva et al. TRENDS IN IMMUNOLOGY
- LncRNA PCGEM1 accelerates non-small cell lung cancer progression via sponging miR-433-3p to upregulate WTAP
- (2020) Lei Weng et al. BMC Pulmonary Medicine
- Cathepsin regulation on microglial function
- (2020) Hiroshi Nakanishi BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- High Wilms’ tumor 1 associating protein expression predicts poor prognosis in acute myeloid leukemia and regulates m6A methylation of MYC mRNA
- (2020) Duolan Naren et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m6A-dependent manner
- (2020) Shijie Chen et al. Cell Death & Disease
- YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways
- (2020) Jiadong Liu et al. Cell Reports
- WTAP Gene Variants Confer Hepatoblastoma Susceptibility: A Seven-Center Case-Control Study
- (2020) Zhen-Jian Zhuo et al. Molecular Therapy-Oncolytics
- M6A RNA Methylation Regulator HNRNPC Contributes to Tumorigenesis and Predicts Prognosis in Glioblastoma Multiforme
- (2020) Li-chong Wang et al. Frontiers in Oncology
- N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability
- (2020) Han Yu et al. BIOMEDICINE & PHARMACOTHERAPY
- Emerging roles of RNA methylation in gastrointestinal cancers
- (2020) Shanshan Xie et al. Cancer Cell International
- m6A methyltransferase Wilms' tumor 1‐associated protein facilitates cell proliferation and cisplatin resistance in NK /T cell lymphoma by regulating dual‐specificity phosphatases 6 expression via m6A RNA methylation
- (2020) HongYan Ma et al. IUBMB LIFE
- Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth
- (2020) Bowen Rong et al. Cell Reports
- LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway
- (2019) Chunhua Wei et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- c-Myc mediated upregulation of long noncoding RNA SNHG12 regulates proliferation and drug sensitivity in natural killer/T-cell lymphoma
- (2019) Linan Zhu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- B7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2
- (2019) Tongguo Shi et al. Cell Death & Disease
- A miR-567-PIK3AP1-PI3K/AKT-c-Myc feedback loop regulates tumour growth and chemoresistance in gastric cancer
- (2019) Feifei Zhang et al. EBioMedicine
- METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner
- (2019) Jie Han et al. Molecular Cancer
- YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation
- (2019) Hao Sheng et al. CARCINOGENESIS
- WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
- (2019) Yunhao Chen et al. Molecular Cancer
- The cell cycle in stem cell proliferation, pluripotency and differentiation
- (2019) Lijun Liu et al. NATURE CELL BIOLOGY
- Reading, writing and erasing mRNA methylation
- (2019) Sara Zaccara et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion
- (2019) Tianfang Xia et al. PATHOLOGY RESEARCH AND PRACTICE
- WTAP is a prognostic marker of high-grade serous ovarian cancer and regulates the progression of ovarian cancer cells
- (2019) Hai-Lan Yu et al. OncoTargets and Therapy
- Hexokinase 2 dimerization and interaction with voltage‐dependent anion channel promoted resistance to cell apoptosis induced by gemcitabine in pancreatic cancer
- (2019) Kun Fan et al. Cancer Medicine
- Bi-allelic Variants in METTL5 Cause Autosomal-Recessive Intellectual Disability and Microcephaly
- (2019) Elodie M. Richard et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1
- (2019) Chaohui Gu et al. Molecular Cancer
- IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader
- (2019) Xiaoge Hu et al. CELL DEATH AND DIFFERENTIATION
- Changes in m6A RNA methylation contribute to heart failure progression by modulating translation
- (2019) Tea Berulava et al. EUROPEAN JOURNAL OF HEART FAILURE
- Functions of N6-methyladenosine and its role in cancer
- (2019) Liuer He et al. Molecular Cancer
- R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling
- (2018) Rui Su et al. CELL
- FTO-Dependent m6A Regulates Cardiac Function During Remodeling and Repair
- (2018) Prabhu Mathiyalagan et al. CIRCULATION
- Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d
- (2018) Philip Knuckles et al. GENES & DEVELOPMENT
- Wilms’ tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2 mRNA stability
- (2018) Jingyuan Tang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Multiple functions of m6A RNA methylation in cancer
- (2018) Yutian Pan et al. Journal of Hematology & Oncology
- Zc3h13 Regulates Nuclear RNA m 6 A Methylation and Mouse Embryonic Stem Cell Self-Renewal
- (2018) Jing Wen et al. MOLECULAR CELL
- Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
- (2018) Huilin Huang et al. NATURE CELL BIOLOGY
- Diffuse large B-cell lymphoma
- (2018) Shaoying Li et al. PATHOLOGY
- N6-methyladenosine links RNA metabolism to cancer progression
- (2018) Dongjun Dai et al. Cell Death & Disease
- Predicting drug resistance related to ABC transporters using unsupervised Consensus Self-Organizing Maps
- (2018) Roger Estrada-Tejedor et al. Scientific Reports
- Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development
- (2018) Seth D. Kasowitz et al. PLoS Genetics
- VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
- (2018) Yanan Yue et al. Cell Discovery
- Wilms’ tumor 1-associating protein plays an aggressive role in diffuse large B-cell lymphoma and forms a complex with BCL6 via Hsp90
- (2018) Yue Kuai et al. Cell Communication and Signaling
- N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
- (2018) Honghui Ma et al. Nature Chemical Biology
- IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner
- (2018) Simon Müller et al. NUCLEIC ACIDS RESEARCH
- RNA Splicing and Disease: Animal Models to Therapies
- (2018) Matías Montes et al. TRENDS IN GENETICS
- Relationship between the genetic expression of WTAP and bladder cancer and patient prognosis
- (2018) Lezhong Chen et al. Oncology Letters
- Base-Resolution Mapping Reveals Distinct m 1 A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts
- (2017) Xiaoyu Li et al. MOLECULAR CELL
- RNA m6A methylation regulates the ultraviolet-induced DNA damage response
- (2017) Yang Xiang et al. NATURE
- Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance
- (2017) A Visvanathan et al. ONCOGENE
- Human m6A writers: Two subunits, 2 roles
- (2017) Xiang Wang et al. RNA Biology
- Hepatoblastoma
- (2017) Divya Sharma et al. SEMINARS IN DIAGNOSTIC PATHOLOGY
- WT1-associated protein is a novel prognostic factor in pancreatic ductal adenocarcinoma
- (2017) Bing-Qi Li et al. Oncology Letters
- m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
- (2017) Qi Cui et al. Cell Reports
- YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
- (2017) Ian A Roundtree et al. eLife
- Diet, Nutrition, and Cancer Epigenetics
- (2016) Carmen Sapienza et al. Annual Review of Nutrition
- A Novel Inhibitor of the Obesity-Related Protein FTO
- (2016) Yan Qiao et al. BIOCHEMISTRY
- METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulatingN6-methyladenosine-dependent primary MicroRNA processing
- (2016) Jin-zhao Ma et al. HEPATOLOGY
- WTAP Expression Predicts Poor Prognosis in Malignant Glioma Patients
- (2016) Zhuo Xi et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- N 6-Methyladenosine (m6A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification
- (2016) Ruifan Wu et al. MOLECULAR BIOTECHNOLOGY
- Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing
- (2016) Wen Xiao et al. MOLECULAR CELL
- Identifying the role of Wilms tumor 1 associated protein in cancer prediction using integrative genomic analyses
- (2016) Li-Sheng Wu et al. Molecular Medicine Reports
- The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate
- (2016) Paweł Lis et al. MOLECULES
- Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex
- (2016) Xiang Wang et al. NATURE
- m6A RNA methylation promotes XIST-mediated transcriptional repression
- (2016) Deepak P. Patil et al. NATURE
- The Warburg Effect: How Does it Benefit Cancer Cells?
- (2016) Maria V. Liberti et al. TRENDS IN BIOCHEMICAL SCIENCES
- 5′ UTR m6A Promotes Cap-Independent Translation
- (2015) Kate D. Meyer et al. CELL
- HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
- (2015) Claudio R. Alarcón et al. CELL
- N6-methyladenosine Modulates Messenger RNA Translation Efficiency
- (2015) Xiao Wang et al. CELL
- N 6-methyladenosine modification in mRNA: machinery, function and implications for health and diseases
- (2015) Arpita Maity et al. FEBS Journal
- Carbonic anhydrase IVinhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP–WT1–TBL1 axis
- (2015) Jingwan Zhang et al. GUT
- Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)
- (2015) Wu He et al. JOURNAL OF MEDICINAL CHEMISTRY
- ATP-binding cassette sub-family C member 4 (ABCC4) is overexpressed in human NK/T-cell lymphoma and regulates chemotherapy sensitivity: Potential as a functional therapeutic target
- (2015) Xudong Zhang et al. LEUKEMIA RESEARCH
- Emerging Roles of RNA Modification: m 6 A and U-Tail
- (2014) Mihye Lee et al. CELL
- FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
- (2014) Xu Zhao et al. CELL RESEARCH
- Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
- (2014) Xiao-Li Ping et al. CELL RESEARCH
- The Drosophila Wilms׳ Tumor 1-Associating Protein (WTAP) homolog is required for eye development
- (2014) Abigail M. Anderson et al. DEVELOPMENTAL BIOLOGY
- Epigenetics in liver disease
- (2014) Derek A. Mann HEPATOLOGY
- WTAP is a novel oncogenic protein in acute myeloid leukemia
- (2014) H Bansal et al. LEUKEMIA
- N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
- (2014) Yang Wang et al. NATURE CELL BIOLOGY
- Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
- (2014) Yue Huang et al. NUCLEIC ACIDS RESEARCH
- Identification of Wilms' Tumor 1-associating Protein Complex and Its Role in Alternative Splicing and the Cell Cycle
- (2013) Keiko Horiuchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- WTAP regulates migration and invasion of cholangiocarcinoma cells
- (2013) Hong-Jae Jo et al. JOURNAL OF GASTROENTEROLOGY
- A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
- (2013) Jianzhao Liu et al. Nature Chemical Biology
- Programming of DNA Methylation Patterns
- (2012) Howard Cedar et al. Annual Review of Biochemistry
- MYC on the Path to Cancer
- (2012) Chi V. Dang CELL
- Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
- (2012) Kate D. Meyer et al. CELL
- Wnt/β-Catenin Signaling and Disease
- (2012) Hans Clevers et al. CELL
- Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor
- (2012) Baoen Chen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact
- (2012) Joshua C. Black et al. MOLECULAR CELL
- ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
- (2012) Guanqun Zheng et al. MOLECULAR CELL
- Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
- (2012) Dan Dominissini et al. NATURE
- Anti-MUC1 antibody inhibits EGF receptor signaling in cancer cells
- (2011) Akinori Hisatsune et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications
- (2010) Jongsook Kim Kemper BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- A Novel Wilms Tumor 1 (WT1) Target Gene Negatively Regulates the WNT Signaling Pathway
- (2010) Myoung Shin Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cyclooxygenase-2 Is Involved in the Up-Regulation of Matrix Metalloproteinase-9 in Cholangiocarcinoma Induced by Tumor Necrosis Factor-α
- (2009) Keita Itatsu et al. AMERICAN JOURNAL OF PATHOLOGY
- The Biology of Chromatin Remodeling Complexes
- (2009) Cedric R. Clapier et al. Annual Review of Biochemistry
- Long non-coding RNAs: insights into functions
- (2009) Tim R. Mercer et al. NATURE REVIEWS GENETICS
- 5-methylcytosine in RNA: detection, enzymatic formation and biological functions
- (2009) Yuri Motorin et al. NUCLEIC ACIDS RESEARCH
- An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1
- (2009) M. K.-H. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A dual role of Cdk2 in DNA damage response
- (2009) Ande Satyanarayana et al. Cell Division
- Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo
- (2008) Yoshiyasu Fukusumi et al. DEVELOPMENTAL DYNAMICS
- Functioning of the Drosophila Wilms'-Tumor-1-Associated Protein Homolog, Fl(2)d, in Sex-Lethal-Dependent Alternative Splicing
- (2008) J. K. M. Penn et al. GENETICS
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