Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress

Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy

(2021) Ming Wu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The REDD1/TXNIP Complex Accelerates Oxidative Stress-Induced Apoptosis of Nucleus Pulposus Cells through the Mitochondrial Pathway

(2021) Huipeng Yin et al.   Oxidative Medicine and Cellular Longevity

Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats

(2020) Ling Xie et al.   Drug Design Development and Therapy

Diabetic nephropathy execrates epithelial-to-mesenchymal transition (EMT) via miR-2467-3p/Twist1 pathway

(2020) Yan Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors

(2020) Shuxi Qiao et al.   GENES & DEVELOPMENT

The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation

(2020) William P. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The tubular hypothesis of nephron filtration and diabetic kidney disease

(2020) Volker Vallon et al.   Nature Reviews Nephrology

Nestin protects podocyte from injury in lupus nephritis by mitophagy and oxidative stress

(2020) Yuexin Tian et al.   Cell Death & Disease

Calcitriol attenuates renal tubular epithelial cells apoptosis via inhibiting p38MAPK signaling in diabetic nephropathy

(2020) Yinfeng Guo et al.   ACTA DIABETOLOGICA

Carbohydrate response element‐binding protein regulates lipid metabolism via mTOR complex1 in diabetic nephropathy

(2020) Nan Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1

(2020) Yong Yang et al.   Frontiers in Pharmacology

FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX

(2019) Linlin Ji et al.   Oxidative Medicine and Cellular Longevity

TXNIP/Redd1 signalling and excessive autophagy: a novel mechanism of myocardial ischaemia/reperfusion injury in mice

(2019) Chao Gao et al.   CARDIOVASCULAR RESEARCH

lncRNA MALAT1 mediated high glucose–induced HK-2 cell epithelial-to-mesenchymal transition and injury

(2019) Jun Zhang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Redd1 protects against post‑infarction cardiac dysfunction by targeting apoptosis and autophagy

(2019) Pianpian Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

BMP-7 inhibits renal fibrosis in diabetic nephropathy via miR-21 downregulation

(2019) Lingling Liu et al.   LIFE SCIENCES

Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells

(2018) Shan Song et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Blocking the REDD1/TXNIP axis ameliorates LPS-induced vascular endothelial cell injury through repressing oxidative stress and apoptosis

(2018) Xuhui Hou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Transparenchymal Renal Pelvis Injection of Recombinant Adeno-Associated Virus Serotype 9 Vectors Is a Practical Approach for Gene Delivery in the Kidney

(2018) Xufeng Shen et al.   Human Gene Therapy Methods

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Emmanuela Gakidou et al.   LANCET

N-Acetyl Cysteine Attenuated the Deleterious Effects of Advanced Glycation End-Products on the Kidney of Non-Diabetic Rats

(2016) Karina Thieme et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Prognostic Value of Tubulointerstitial Lesions, Urinary N-Acetyl- -D-Glucosaminidase, and Urinary  2-Microglobulin in Patients with Type 2 Diabetes and Biopsy-Proven Diabetic Nephropathy

(2016) K. Mise et al.   Clinical Journal of the American Society of Nephrology

Thioredoxin-interacting protein regulates lipid metabolism via Akt/mTOR pathway in diabetic kidney disease

(2016) Chunyang Du et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy

(2016) O. Alvarez-Garcia et al.   OSTEOARTHRITIS AND CARTILAGE

Is REDD1 a Metabolic Éminence Grise ?

(2016) Christopher Lipina et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway

(2016) Chunling Huang et al.   Scientific Reports

Inhibition of c-Src/p38 MAPK pathway ameliorates renal tubular epithelial cells apoptosis in db/db mice

(2015) Haijiang Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

(2015) Shuxi Qiao et al.   Nature Communications

Knockdown of thioredoxin-interacting protein ameliorates high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells

(2013) Jinying Wei et al.   CELLULAR SIGNALLING

Diabetic nephropathy: Traditional to proteomic markers

(2013) Rafael N. Moresco et al.   CLINICA CHIMICA ACTA

Epidemiology of Diabetic Kidney Disease

(2013) Anne T. Reutens   MEDICAL CLINICS OF NORTH AMERICA

Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocin-induced diabetic muscle atrophy

(2011) Juha J. Hulmi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes.

(2011) Jason K. Molitoris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1

(2011) H-O Jin et al.   ONCOGENE

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

(2010) Toshinori Yoshida et al.   NATURE MEDICINE

Elevated Corticosterone Associated with Food Deprivation Upregulates Expression in Rat Skeletal Muscle of the mTORC1 Repressor, REDD1

(2009) Nora K. McGhee et al.   JOURNAL OF NUTRITION

Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes

(2008) J. M. Forbes et al.   DIABETES