Article
Immunology
Yuewen Tang, Feng Wan, Xuanli Tang, Yi Lin, Huaqin Zhang, Jiawei Cao, Ruchun Yang
Summary: Proteinuria is a risk factor for the progression of diabetic nephropathy and an imbalance in podocyte function exacerbates proteinuria. Celastrol, the active ingredient of T. wilfordii, has been effective in treating renal injury in diabetic nephropathy, but its mechanisms are unclear. This study investigated how celastrol prevents podocyte damage in diabetic nephropathy using in vivo and in vitro experiments. Celastrol reduced blood glucose levels, attenuated renal histomorphological injury, and induced anti-inflammatory effects. It upregulated SIRT1 expression and downregulated EZH2, inhibiting the wnt/beta-catenin pathway. SIRT1 repression aggravated podocyte injury, while celastrol protected podocyte injury via SIRT1/EZH2 in the wnt/beta-catenin pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ruixue Guo, Peipei Wang, Xuejun Zheng, Wen Cui, Jin Shang, Zhanzheng Zhao
Summary: This study demonstrates that the SGLT2 inhibitor dapagliflozin protects podocytes from diabetic nephropathy by regulating the IGF1R/PI3K signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Developmental Biology
Sara E. Billings, Nina M. Myers, Lee Quiruz, Alan G. Cheng
Summary: During mammalian cochlear development, epithelial sensory precursors and periotic mesenchymal cells from distinct lineages coordinate through Wnt activation to promote proliferation and differentiation, driving the transition between epithelial and mesenchymal states in a cell type-dependent manner.
Review
Cell Biology
Haiying Wang, Ran Zhang, Xinjie Wu, Yafen Chen, Wei Ji, Jingsuo Wang, Yawen Zhang, Yong Xia, Yiqun Tang, Jinxiang Yuan
Summary: Diabetic nephropathy is a serious kidney complication of diabetes that can lead to kidney failure. The role of the Wnt signaling pathway in regulating the development of diabetic nephropathy is significant.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Minghan Guan, Yifeng Huang, Xiaowen Lin
Summary: This study found that sufentanil can inhibit the proliferation, migration, invasion, and epithelial-mesenchymal transition of lung cancer cells by regulating the Wnt/beta-catenin signaling pathway.
Article
Chemistry, Applied
Chunfan Huang, Xiaoqi Jing, Qianhu Wu, Kan Ding
Summary: This study discovered that a polysaccharide named SQD4S2 extracted from Panax notoginseng could reverse the morphological changes of human renal tubular HK-2 cells induced by TGF-beta and impede critical fibrogenesis associated molecules expression, indicating the potential of SQD4S2 as a novel leading polysaccharide for new drug development against renal fibrosis.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Lifang He, Qingke Li, Chunyang Du, Yanyun Xue, Pei Yu
Summary: This study found that Glis2 expression was downregulated in Diabetic kidney disease (DKD) and overexpression of Glis2 inhibited the apoptosis and epithelial-to-mesenchymal transition (EMT) of renal tubular epithelial cells (TECs). Furthermore, Glis2 overexpression also suppressed the activation of the beta-catenin signaling pathway, which played a role in protecting against tubular injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Plant Sciences
Wenhao Liao, Yueqiang Wen, Jing Wang, Maoyuan Zhao, Shangbin Lv, Nianzhi Chen, Yuchen Li, Lina Wan, Qiao Zheng, Yu Mou, Ziyi Zhao, Jianyuan Tang, Jinhao Zeng
Summary: This study aims to investigate the role and potential mechanism of GA on gastric precancerous lesions (GPL), the key turning point of gastritis to gastric cancer, with the aim of delaying, blocking or reversing the dynamic overall process of inflammation-cancer transformation and thus blocking GPL to prevent the development of gastric cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Haoran Kong, Wenhui Yu, Zhuning Chen, Haonan Li, Guiwen Ye, Jiacong Hong, Zhongyu Xie, Keng Chen, Yanfeng Wu, Huiyong Shen
Summary: The study demonstrates that CCR9 promotes osteosarcoma lung metastasis by activating the Wnt/beta-catenin signaling pathway, suggesting that CCR9 may be a promising therapeutic target to inhibit lung metastasis and serve as a novel prognostic marker for osteosarcoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Urology & Nephrology
Xiaowen Chen, Huishi Tan, Jie Xu, Yuan Tian, Qian Yuan, Yangyang Zuo, Qiyan Chen, Xue Hong, Haiyan Fu, Fan Fan Hou, Lili Zhou, Youhua Liu
Summary: The Klotho-derived peptide KP6 mimics the protective effects of Klotho in diabetic kidney disease, alleviating established proteinuria, glomerular hypertrophy, podocyte damage, glomerulosclerosis, and interstitial fibrotic lesions by blocking the Wnt/beta-catenin signaling pathway.
KIDNEY INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Liang Zhang, Chuan-fu Ren, Zhi Yang, Long-bo Gong, Chao Wang, Min Feng, Wen-xian Guan
Summary: FOXS1 plays a role in promoting cell proliferation, migration, invasion, and metastasis in colorectal cancer through the Wnt/beta-catenin signaling pathway, making it a potential target for CRC treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Correction
Oncology
Juntao Sun, Tianyu Zhang, Mengmeng Cheng, Liwen Hong, Chen Zhang, Mengfan Xie, Peijun Sun, Rong Fan, Zhengting Wang, Lei Wang, Jie Zhong
Summary: An amendment to the paper has been published and is accessible through the original article.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Chunhua Hu, Mujie Ye, Jianan Bai, Pengfei Liu, Feiyu Lu, Jinhao Chen, Ping Yu, Tiaotiao Chen, Xiaoting Shi, Qiyun Tang
Summary: This study investigated the role of upregulated metabolites of aged serum in colorectal cancer (CRC) progression. Methylmalonic acid (MMA) was found to be responsible for tumorigenesis and metastasis in CRC. Through Wnt/beta-catenin signaling pathway mediated epithelial-mesenchymal transition (EMT), MMA promoted CRC progression. These findings highlight the importance of age-related metabolic reprogramming in CRC and suggest a potential therapeutic target for elderly patients.
CANCER CELL INTERNATIONAL
(2023)
Article
Dermatology
Di Wang, Shuheng Li, Yishan Chen, Jialiang Luo, Lei Li, Bocheng Wang, Yingping Xu, Yunsheng Liang
Summary: This study aims to prove the efficacy of sodium thiosulfate (STS) in melanoma treatment. The results showed that STS inhibited the proliferation, viability, and epithelial-mesenchymal transition (EMT) process of melanoma by releasing H2S. The mechanism of action involved the inhibition of the Wnt/beta-catenin signaling pathway.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2023)
Article
Cell Biology
Lingfei Li, Yanhai Feng, Junhui Zhang, Qiong Zhang, Jun Ren, Cheng Sun, Shujing Li, Xia Lei, Gaoxing Luo, Jiongyu Hu, Yuesheng Huang
Summary: In this study, the researchers investigated the role of MAP4 phosphorylation in causing proteinuria in diabetic nephropathy (DN). They found that the content of p-MAP4 was increased in the urine samples of diabetic patients and in the kidney tissues of diabetic mice. p-MAP4 triggered proteinuria by inducing epithelial-to-mesenchymal transition and apoptosis in podocytes. The study also showed that mice with MAP4 hyperphosphorylation were more susceptible to a certain diabetes treatment and exhibited more severe DN pathology compared to wild-type mice. In vitro experiments further revealed that high glucose triggered the elevation of p-MAP4 and various pathological changes in podocytes, which were rectified by MAP4 dephosphorylation. The findings suggest that p-MAP4 plays a novel role in causing proteinuria in DN and indicate the therapeutic potential of MAP4 in protecting against proteinuria and related diseases.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Pharmacology & Pharmacy
Wenqian Zhang, Tingting Zhao, Yonghua Zhao, Dingkun Gui, Youhua Xu
CURRENT VASCULAR PHARMACOLOGY
(2020)
Article
Immunology
Junling Gu, Wei Huang, Wenqian Zhang, Tingting Zhao, Chenlin Gao, Wenjun Gan, Mingyue Rao, Qing Chen, Man Guo, Yong Xu, You-Hua Xu
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Article
Plant Sciences
Xia Zhen-Yan, Luo Cheng, Liu Bo-Wen, Bian Xi-Qing, Li Yang, Pang Ai-Ming, Xu You-Hua, Tan Hong-Mei, Zhao Yong-Hua
Article
Endocrinology & Metabolism
Rui Xue, Ruonan Zhai, Ling Xie, Zening Zheng, Guihua Jian, Teng Chen, Jun Su, Chongting Gao, Niansong Wang, Xifei Yang, Youhua Xu, Dingkun Gui
JOURNAL OF DIABETES RESEARCH
(2020)
Review
Pharmacology & Pharmacy
Tingting Zhao, Zhe Wang, Zhilong Liu, Youhua Xu
Summary: Dysfunction or imbalance of gut microbiota is closely related to disease progression, and herbal medicines play a role in preventing and treating diseases by modulating gut microbiota, which is a complex yet important mechanism.
CURRENT DRUG TARGETS
(2021)
Article
Cell Biology
Tingting Zhao, Junling Gu, Huixia Zhang, Zhe Wang, Wenqian Zhang, Yonghua Zhao, Ying Zheng, Wei Zhang, Hua Zhou, Guilin Zhang, Qingmin Sun, Enchao Zhou, Zhilong Liu, Youhua Xu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Integrative & Complementary Medicine
Qian Bai, Yaochen Chuang, Yonghua Zhao, Yao Wang, Pu Ge, Youhua Xu, Ying Bian
Summary: This study found a relatively high prevalence rate of biased TCM constitutions among elderly residents in Macau, with distribution differences related to gender, age, education level, sleeping habits, and lifestyle behaviors. Controlling these influential factors may benefit the health management of elderly individuals in Macau.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Yinyan Xu, Hengli Guo, Tingting Zhao, Jing Fu, Youhua Xu
Summary: Cortex Mori and its active component mulberroside A can ameliorate diabetic endotoxemia by preserving gut integrity.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Agriculture, Multidisciplinary
Zhi-Tong Zhang, Ning Guo, Guo-Dong Zhuang, Si-Min Deng, Wen-Jiao He, Zhi-Quan Chen, You-Hua Xu, Dan Tang, Shu-Mei Wang
Summary: The research found that Pueraria lobata extracts containing a total of 73 identified compounds could ameliorate kidney injury and regulate abnormal glycolipid metabolism. In metabolomics analysis, 19 carbonyl compounds with significant differences were identified between DN mice and normal mice, while 12 metabolites had a tendency to return to normal levels after PL treatment. Overall, Pueraria lobata exerts beneficial effects on DN by regulating abnormal glycolipid metabolism and carbonyl stress, and endogenous carbonyl compounds might serve as potential biomarkers for DN.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Tingting Zhao, Jiaye Tian, Tiancheng Xu, Xi Zhang, Qian Xiang, Jianfeng Xiong, Dingkun Gui, Youhua Xu
Summary: This study investigated the protective effect and mechanism of astragaloside IV (AS-IV) on damage in human glomerular endothelial cells (GEnCs) stimulated by high glucose and high insulin. The results showed that AS-IV had a significant protective effect on the cell barrier of GEnCs. It increased cell energy metabolism and viability, inhibited inflammation and oxidative stress damage, and enhanced tight junction between cells.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Integrative & Complementary Medicine
Wei Zhang, Jun Li, Pan Yang, Gaoqiang Wang, Yanli Yue, Yuanfang Zhong, Hanyin Liu, Dingkun Gui, Youhua Xu, Niansong Wang
Summary: This meta-analysis evaluated the effects of Salvia miltiorrhiza or its extracts Salvianolate and Tanshinone on chronic kidney disease (CKD). The results showed that these treatments had potential impacts in improving kidney functions and delaying CKD progression without obvious adverse effects. However, further clinical studies are needed to determine the underlying effects.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Jing Lin, Guangde Liu, Yuxuan Lin, Chao Wei, Sujun Liu, Youhua Xu
Summary: This study investigated the relationship between the ultrasound performance of intrarenal arteries and the grade of DKD. The resistance index (RI) of intrarenal arteries obtained from ultrasonography combined with the level of hemoglobin (Hb) was found to be a predictor of the progression of DKD.
Review
Integrative & Complementary Medicine
Junling Gu, Kang Geng, Man Guo, Wei Huang, Tingting Zhao, Xuling Li, You-Hua Xu, Yong Xu
Summary: This review summarizes the molecular mechanisms, regulation, and cellular effects of pyroptosis in diabetic microvascular complications and aims to provide new insights into identifying better treatments.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Endocrinology & Metabolism
Zhongyan Sun, Yadi Liu, Yonghua Zhao, Youhua Xu
Summary: This paper summarizes and classifies the animal modeling approaches to the complications of type 2 diabetes, and provides a comprehensive review of their advantages and disadvantages. It is hopeful that this research will provide theoretical support for animal trials of diabetic complications.
ENDOCRINE RESEARCH
(2023)
