Chronic exposure to realistic concentrations of metformin prompts a neurotoxic response in Danio rerio adults

Chronic exposure to environmentally relevant concentrations of guanylurea induces neurotoxicity of Danio rerio adults

(2022) Gustavo Axel Elizalde-Velázquez et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Metformin leads to accumulation of reactive oxygen species by inhibiting the NFE2L1 expression in human hepatocellular carcinoma cells

(2021) Shanshan Gou et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Antidiabetic drug metformin disrupts the embryogenesis in zebrafish through an oxidative stress mechanism

(2021) Gustavo Axel Elizalde-Velázquez et al.   CHEMOSPHERE

Developmental phenotypic and transcriptomic effects of exposure to nanomolar levels of metformin in zebrafish

(2021) Jessica Phillips et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Induction of apoptosis in the gonads of Mytilus edulis by metformin and increased temperature, via regulation of HSP70, CASP8, BCL2 and FAS

(2021) Wulan Koagouw et al.   MARINE POLLUTION BULLETIN

Oxidative stress as a potential mechanism by which guanylurea disrupts the embryogenesis of Danio rerio

(2021) Gustavo Axel Elizalde-Velázquez et al.   SCIENCE OF THE TOTAL ENVIRONMENT

The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2020) Yuanyuan Guan et al.   International Journal of Endocrinology

Metformin-Induced Epigenetic Toxicity in Zebrafish: Experimental and Molecular Dynamics Simulation Studies

(2020) Wenting Lin et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The anticancer potential of metformin on prostate cancer

(2019) Saher Zaidi et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways

(2019) Artem P. Gureev et al.   Frontiers in Genetics

RNA-seq Based Transcriptome Analysis of the Anti-Obesity Effect of Green Tea Extract Using Zebrafish Obesity Models

(2019) Zang et al.   MOLECULES

Genotoxic and cytotoxic alterations induced by environmentally-relevant concentrations of amoxicillin in blood cells of Cyprinus carpio

(2019) José Manuel Orozco-Hernández et al.   CHEMOSPHERE

Ketamine induction of p53-dependent apoptosis and oxidative stress in zebrafish ( Danio rerio ) embryos

(2018) Luís M. Félix et al.   CHEMOSPHERE

Metformin in cancer

(2018) Ritwika Mallik et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Occurrence and indicators of pharmaceuticals in Chinese streams: A nationwide study

(2018) Bo Yao et al.   ENVIRONMENTAL POLLUTION

Environmental concentrations of metformin exposure affect aggressive behavior in the Siamese fighting fish, Betta splendens

(2018) Ronald David MacLaren et al.   PLoS One

Suspect screening and target quantification of human pharmaceutical residues in the surface water of Wuhan, China, using UHPLC-Q-Orbitrap HRMS

(2018) Muhammad Ali Asghar et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Metformin protects PC12 cells against oxygen-glucose deprivation/reperfusion injury

(2018) Elnaz Mohammad Alizadeh et al.   TOXICOLOGY MECHANISMS AND METHODS

Metformin protects PC12 cells against oxygen-glucose deprivation/reperfusion injury

(2018) Elnaz Mohammad Alizadeh et al.   TOXICOLOGY MECHANISMS AND METHODS

Metformin selectively targets redox control of complex I energy transduction

(2018) Amy R. Cameron et al.   Redox Biology

Ecotoxicological effects, water quality standards and risk assessment for the anti-diabetic metformin

(2018) Aline Andrade Godoy et al.   ENVIRONMENTAL POLLUTION

The BACE1-PSEN-AβPP Regulatory Axis has an Ancient Role in Response to Low Oxygen/Oxidative Stress

(2018) Seyyed Hani Moussavi Nik et al.   JOURNAL OF ALZHEIMERS DISEASE

Metformin inhibits human breast cancer cell growth by promoting apoptosis via a ROS-independent pathway involving mitochondrial dysfunction: pivotal role of superoxide dismutase (SOD)

(2018) Prateek Sharma et al.   CELLULAR ONCOLOGY

Effects of environmentally relevant metformin exposure on Japanese medaka (Oryzias latipes)

(2018) Erin Ussery et al.   AQUATIC TOXICOLOGY

Does the antidiabetic drug metformin affect embryo development and the health of brown trout (Salmo trutta f. fario)?

(2018) Stefanie Jacob et al.   Environmental Sciences Europe

Metformin-induced endocrine disruption and oxidative stress of Oryzias latipes on two-generational condition

(2018) Jin Wuk Lee et al.   JOURNAL OF HAZARDOUS MATERIALS

Contaminants of emerging concern in tributaries to the Laurentian Great Lakes: I. Patterns of occurrence

(2017) Sarah M. Elliott et al.   PLoS One

Hydrogen peroxide modifies both activity and isoforms of acetylcholinesterase in human neuroblastoma SH-SY5Y cells

(2017) Alba Garcimartín et al.   Redox Biology

Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates

(2016) Pasquale Picone et al.   Aging-US

Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice

(2016) Joanne S. Allard et al.   BEHAVIOURAL BRAIN RESEARCH

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Atrazine and its main metabolites alter the locomotor activity of larval zebrafish (Danio rerio)

(2016) Zhenzhen Liu et al.   CHEMOSPHERE

Contaminants of emerging concern in a large temperate estuary

(2016) James P. Meador et al.   ENVIRONMENTAL POLLUTION

Age-dependent effects in fathead minnows from the anti-diabetic drug metformin

(2016) Jordan Crago et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors

(2016) Lei Lei et al.   NUCLEIC ACIDS RESEARCH

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

(2015) Puyu Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect

(2015) Pasquale Picone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

AChE inhibition: One dominant factor for swimming behavior changes of Daphnia magna under DDVP exposure

(2015) Zongming Ren et al.   CHEMOSPHERE

Repeated Blood Collection for Blood Tests in Adult Zebrafish

(2015) Liqing Zang et al.   Jove-Journal of Visualized Experiments

Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity

(2014) Benedetta Mannini et al.   ACS Chemical Biology

Metformin exposure at environmentally relevant concentrations causes potential endocrine disruption in adult male fish

(2014) Nicholas J. Niemuth et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Embryonic exposure to carbendazim induces the transcription of genes related to apoptosis, immunotoxicity and endocrine disruption in zebrafish (Danio rerio)

(2014) Jinhua Jiang et al.   FISH & SHELLFISH IMMUNOLOGY

Amyloid Aggregation: Role of Biological Membranes and the Aggregate–Membrane System

(2014) Monica Bucciantini et al.   Journal of Physical Chemistry Letters

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

Subchronic atrazine exposure changes defensive behaviour profile and disrupts brain acetylcholinesterase activity of zebrafish

(2014) Ademir J. Schmidel et al.   NEUROTOXICOLOGY AND TERATOLOGY

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide

(2014) Krzysztof Łabuzek et al.   Pharmacological Reports

Ecological effects of pharmaceuticals in aquatic systems--impacts through behavioural alterations

(2014) T. Brodin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer

(2013) Cecilia Marini et al.   CELL CYCLE

Oxidative stress responses in zebrafish Danio rerio after subchronic exposure to atrazine

(2013) Jana Blahová et al.   FOOD AND CHEMICAL TOXICOLOGY

Novel Blood Collection Method Allows Plasma Proteome Analysis from Single Zebrafish

(2013) Fatemeh Babaei et al.   JOURNAL OF PROTEOME RESEARCH

Sugar for the brain: the role of glucose in physiological and pathological brain function

(2013) Philipp Mergenthaler et al.   TRENDS IN NEUROSCIENCES

Histopathological changes and antioxidant response in brain and kidney of common carp exposed to atrazine and chlorpyrifos

(2012) Houjuan Xing et al.   CHEMOSPHERE

Toxic effects of amyloid fibrils on cell membranes: the importance of ganglioside GM1

(2011) Monica Bucciantini et al.   FASEB JOURNAL

Nrf2b, Novel Zebrafish Paralog of Oxidant-responsive Transcription Factor NF-E2-related Factor 2 (NRF2)

(2011) Alicia R. Timme-Laragy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Toxicity of the Herbicide Atrazine: Effects on Lipid Peroxidation and Activities of Antioxidant Enzymes in the Freshwater Fish Channa Punctatus (Bloch)

(2010) Christopher Ddidigwu Nwani et al.   International Journal of Environmental Research and Public Health

Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish (Danio rerio)

(2009) Yuanxiang Jin et al.   CHEMOSPHERE

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin induces apoptosis of pancreatic cancer cells

(2008) Luo-Wei Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY