Chronic exposure to environmentally relevant concentrations of guanylurea induces neurotoxicity of Danio rerio adults

An ‘omics approach to investigate the growth effects of environmentally relevant concentrations of guanylurea exposure on Japanese medaka (Oryzias latipes)

(2021) Erin J. Ussery et al.   AQUATIC TOXICOLOGY

Metformin Inhibits Lipoteichoic Acid–Induced Oxidative Stress and Inflammation Through AMPK/NRF2/NF-κB Signaling Pathway in Bovine Mammary Epithelial Cells

(2021) Abdelaziz Adam Idriss Arbab et al.   Frontiers in Veterinary Science

Antidiabetic drug metformin disrupts the embryogenesis in zebrafish through an oxidative stress mechanism

(2021) Gustavo Axel Elizalde-Velázquez et al.   CHEMOSPHERE

Induction of apoptosis in the gonads of Mytilus edulis by metformin and increased temperature, via regulation of HSP70, CASP8, BCL2 and FAS

(2021) Wulan Koagouw et al.   MARINE POLLUTION BULLETIN

Oxidative stress as a potential mechanism by which guanylurea disrupts the embryogenesis of Danio rerio

(2021) Gustavo Axel Elizalde-Velázquez et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Metformin in COVID-19: A possible role beyond diabetes

(2020) Swati Sharma et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Anticancer mechanisms of metformin: A review of the current evidence

(2020) Bin Zhao et al.   LIFE SCIENCES

Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish

(2020) Rakesh Kumar Banote et al.   Scientific Reports

An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish

(2020) Ana CVV Giacomini et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Metformin-Induced Epigenetic Toxicity in Zebrafish: Experimental and Molecular Dynamics Simulation Studies

(2020) Wenting Lin et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Efficacy of simvastatin plus metformin for polycystic ovary syndrome: A meta-analysis of randomized controlled trials

(2020) Jie Meng et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Developmental and full-life cycle exposures to guanylurea, and guanylurea-metformin mixtures results in adverse effects on Japanese medaka (Oryzias latipes )

(2019) Erin Ussery et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways

(2019) Artem P. Gureev et al.   Frontiers in Genetics

Neurotoxicity of organophosphate pesticides could reduce the ability of fish to escape predation under low doses of exposure

(2019) Natalia Sandoval-Herrera et al.   Scientific Reports

RNA-seq Based Transcriptome Analysis of the Anti-Obesity Effect of Green Tea Extract Using Zebrafish Obesity Models

(2019) Zang et al.   MOLECULES

Occurrence, toxic effects and removal of metformin in the aquatic environments in the world: Recent trends and perspectives

(2019) Gustavo Axel Elizalde-Velázquez et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Triclosan alters adult zebrafish behavior and targets acetylcholinesterase activity and expression

(2019) Narasimha Pullaguri et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Ketamine induction of p53-dependent apoptosis and oxidative stress in zebrafish ( Danio rerio ) embryos

(2018) Luís M. Félix et al.   CHEMOSPHERE

Occurrence and indicators of pharmaceuticals in Chinese streams: A nationwide study

(2018) Bo Yao et al.   ENVIRONMENTAL POLLUTION

Environmental concentrations of metformin exposure affect aggressive behavior in the Siamese fighting fish, Betta splendens

(2018) Ronald David MacLaren et al.   PLoS One

Formation and occurrence of transformation products of metformin in wastewater and surface water

(2018) Selina Tisler et al.   SCIENCE OF THE TOTAL ENVIRONMENT

The BACE1-PSEN-AβPP Regulatory Axis has an Ancient Role in Response to Low Oxygen/Oxidative Stress

(2018) Seyyed Hani Moussavi Nik et al.   JOURNAL OF ALZHEIMERS DISEASE

Metformin inhibits human breast cancer cell growth by promoting apoptosis via a ROS-independent pathway involving mitochondrial dysfunction: pivotal role of superoxide dismutase (SOD)

(2018) Prateek Sharma et al.   CELLULAR ONCOLOGY

Effects of environmentally relevant metformin exposure on Japanese medaka (Oryzias latipes)

(2018) Erin Ussery et al.   AQUATIC TOXICOLOGY

Aerobic and anaerobic formation and biodegradation of guanyl urea and other transformation products of metformin

(2018) Selina Tisler et al.   WATER RESEARCH

Metformin-induced endocrine disruption and oxidative stress of Oryzias latipes on two-generational condition

(2018) Jin Wuk Lee et al.   JOURNAL OF HAZARDOUS MATERIALS

Metformin and Its Sulfenamide Prodrugs Inhibit Human Cholinesterase Activity

(2017) Magdalena Markowicz-Piasecka et al.   Oxidative Medicine and Cellular Longevity

Contaminants of emerging concern in tributaries to the Laurentian Great Lakes: I. Patterns of occurrence

(2017) Sarah M. Elliott et al.   PLoS One

Metformin: a review of its potential indications

(2017) Yi-Wei Wang et al.   Drug Design Development and Therapy

The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo

(2017) Karilyn E. Sant et al.   Redox Biology

Hydrogen peroxide modifies both activity and isoforms of acetylcholinesterase in human neuroblastoma SH-SY5Y cells

(2017) Alba Garcimartín et al.   Redox Biology

Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium

(2016) C. R. Triggle et al.   Acta Physiologica

Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates

(2016) Pasquale Picone et al.   Aging-US

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

(2016) Fiona A. Ross et al.   FEBS Journal

Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors

(2016) Lei Lei et al.   NUCLEIC ACIDS RESEARCH

p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells

(2015) Puyu Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect

(2015) Pasquale Picone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

AChE inhibition: One dominant factor for swimming behavior changes of Daphnia magna under DDVP exposure

(2015) Zongming Ren et al.   CHEMOSPHERE

Differential expression ofprotocadherin-19,protocadherin-17, andcadherin-6in adult zebrafish brain

(2015) Qin Liu et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Comprehensive study of the antidiabetic drug metformin and its transformation product guanylurea in Greek wastewaters

(2015) Christina I. Kosma et al.   WATER RESEARCH

Occurrence of the antidiabetic drug Metformin and its ultimate transformation product Guanylurea in several compartments of the aquatic cycle

(2014) Christoph Trautwein et al.   ENVIRONMENT INTERNATIONAL

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

Occurrence and fate of the antidiabetic drug metformin and its metabolite guanylurea in the environment and during drinking water treatment

(2012) Marco Scheurer et al.   WATER RESEARCH

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Swimming impairment and acetylcholinesterase inhibition in zebrafish exposed to copper or chlorpyrifos separately, or as mixtures

(2010) Fred A. Tilton et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Measuring behavioral and endocrine responses to novelty stress in adult zebrafish

(2010) Jonathan Cachat et al.   Nature Protocols

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin induces apoptosis of pancreatic cancer cells

(2008) Luo-Wei Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY