Metformin leads to accumulation of reactive oxygen species by inhibiting the NFE2L1 expression in human hepatocellular carcinoma cells

Glucose Starvation-Induced Rapid Death of Nrf1α-Deficient, but Not Nrf2-Deficient, Hepatoma Cells Results from Its Fatal Defects in the Redox Metabolism Reprogramming

(2020) Yu-ping Zhu et al.   Oxidative Medicine and Cellular Longevity

Metformin protects high glucose‑cultured cardiomyocytes from oxidative stress by promoting NDUFA13 expression and mitochondrial biogenesis via the AMPK signaling pathway

(2020) Xiang‑Dong Liu et al.   Molecular Medicine Reports

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

(2019) Mohamed Elgendy et al.   CANCER CELL

Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression

(2019) Nicolas J. Lehrbach et al.   CELL

Metformin in 2019

(2019) James Flory et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metformin Ameliorates Testicular Damage in Male Mice with Streptozotocin-Induced Type 1 Diabetes through the PK2/PKR Pathway

(2019) Yuning Liu et al.   Oxidative Medicine and Cellular Longevity

Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARγ expression

(2019) Lu Li et al.   Redox Biology

Long isoforms of NRF1 negatively regulate adipogenesis via suppression of PPARγ expression

(2019) Peng Xue et al.   Redox Biology

Unification of Opposites between Two Antioxidant Transcription Factors Nrf1 and Nrf2 in Mediating Distinct Cellular Responses to the Endoplasmic Reticulum Stressor Tunicamycin

(2019) Yu-ping Zhu et al.   Antioxidants

Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice

(2018) Yongyong Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin Promotes HaCaT Cell Apoptosis through Generation of Reactive Oxygen Species via Raf-1-ERK1/2-Nrf2 Inactivation

(2018) Xiaoyan Wang et al.   INFLAMMATION

A review of the molecular mechanisms of hyperglycemia-induced free radical generation leading to oxidative stress

(2018) Habib Yaribeygi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor

(2018) Yuancai Xiang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metformin induces significant reduction of body weight, total cholesterol and LDL levels in the elderly – A meta-analysis

(2018) Margit Solymár et al.   PLoS One

Mechanisms controlling the multistage post-translational processing of endogenous Nrf1α/TCF11 proteins to yield distinct isoforms within the coupled positive and negative feedback circuits

(2018) Yuancai Xiang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oncogenic Activation of Nrf2, Though as a Master Antioxidant Transcription Factor, Liberated by Specific Knockout of the Full-Length Nrf1α that Acts as a Dominant Tumor Repressor

(2018) Lu Qiu et al.   Cancers

Variability in the Therapeutic Response of Metformin treatment in patients with type 2 diabetes Mellitus

(2018) Maryam Rashid et al.   Pakistan Journal of Medical Sciences

Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity

(2016) Y. Zhang et al.   BIOCHEMICAL JOURNAL

Metformin Activates AMPK through the Lysosomal Pathway

(2016) Chen-Song Zhang et al.   Cell Metabolism

Tetrabromobisphenol A (TBBPA)-stimulated reactive oxygen species (ROS) production in cell-free model using the 2′,7′-dichlorodihydrofluorescein diacetate (H2DCFDA) assay—limitations of method

(2016) Konrad A. Szychowski et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

CNC-bZIP Protein Nrf1-Dependent Regulation of Glucose-Stimulated Insulin Secretion

(2015) Hongzhi Zheng et al.   ANTIOXIDANTS & REDOX SIGNALING

mTORC1 signaling activates NRF1 to increase cellular proteasome levels

(2015) Yinan Zhang et al.   CELL CYCLE

Therapeutic Use of Metformin in Prediabetes and Diabetes Prevention

(2015) Ulrike Hostalek et al.   DRUGS

The involvement of p62–Keap1–Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity

(2015) Li-Li Ji et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diabetes, oxidative stress and therapeutic strategies

(2014) Luc Rochette et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice

(2014) Yosuke Hirotsu et al.   GENES TO CELLS

Coordinated regulation of protein synthesis and degradation by mTORC1

(2014) Yinan Zhang et al.   NATURE

Mechanisms by Which Low Glucose Enhances the Cytotoxicity of Metformin to Cancer Cells Both In Vitro and In Vivo

(2014) Yongxian Zhuang et al.   PLoS One

Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways

(2013) Minh Truong Do et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Embryonic Lethality and Fetal Liver Apoptosis in Mice Lacking All Three Small Maf Proteins

(2011) H. Yamazaki et al.   MOLECULAR AND CELLULAR BIOLOGY

Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

(2010) Xinguo Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane

(2010) Yiguo Zhang et al.   BIOCHEMICAL JOURNAL

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Function of reactive oxygen species during animal development: Passive or active?

(2008) Luis Covarrubias et al.   DEVELOPMENTAL BIOLOGY