Antidiabetic drug metformin disrupts the embryogenesis in zebrafish through an oxidative stress mechanism

Chronic Embryo‐Larval Exposure of Fathead Minnows to the Pharmaceutical Drug Metformin: Survival, Growth, and Microbiome Responses

(2021) Joanne L. Parrott et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2020) Yuanyuan Guan et al.   International Journal of Endocrinology

The anticancer potential of metformin on prostate cancer

(2019) Saher Zaidi et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Embryonic development, locomotor behavior, biochemical, and epigenetic effects of the pharmaceutical drugs paracetamol and ciprofloxacin in larvae and embryos of Danio rerio when exposed to environmental realistic levels of both drugs

(2019) Ana F. Nogueira et al.   ENVIRONMENTAL TOXICOLOGY

Occurrence, toxic effects and removal of metformin in the aquatic environments in the world: Recent trends and perspectives

(2019) Gustavo Axel Elizalde-Velázquez et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Immune-mediated anti-tumor effects of metformin; targeting metabolic reprogramming of T cells as a new possible mechanism for anti-cancer effects of metformin

(2019) Saman Bahrambeigi et al.   BIOCHEMICAL PHARMACOLOGY

Low-dose metformin exposure causes changes in expression of endocrine disruption-associated genes

(2018) Nicholas J. Niemuth et al.   AQUATIC TOXICOLOGY

Occurrence and indicators of pharmaceuticals in Chinese streams: A nationwide study

(2018) Bo Yao et al.   ENVIRONMENTAL POLLUTION

Metformin selectively targets redox control of complex I energy transduction

(2018) Amy R. Cameron et al.   Redox Biology

Effects of environmentally relevant metformin exposure on Japanese medaka (Oryzias latipes)

(2018) Erin Ussery et al.   AQUATIC TOXICOLOGY

Does the antidiabetic drug metformin affect embryo development and the health of brown trout (Salmo trutta f. fario)?

(2018) Stefanie Jacob et al.   Environmental Sciences Europe

Metformin-induced endocrine disruption and oxidative stress of Oryzias latipes on two-generational condition

(2018) Jin Wuk Lee et al.   JOURNAL OF HAZARDOUS MATERIALS

Triazole Fungicides Inhibit Zebrafish Hatching by Blocking the Secretory Function of Hatching Gland Cells

(2017) Javiera De la Paz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Contaminants of emerging concern in tributaries to the Laurentian Great Lakes: I. Patterns of occurrence

(2017) Sarah M. Elliott et al.   PLoS One

Age-dependent effects in fathead minnows from the anti-diabetic drug metformin

(2016) Jordan Crago et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish

(2015) Nicholas J. Niemuth et al.   CHEMOSPHERE

Metformin exposure at environmentally relevant concentrations causes potential endocrine disruption in adult male fish

(2014) Nicholas J. Niemuth et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Metformin Induces Apoptosis and Cell Cycle Arrest Mediated by Oxidative Stress, AMPK and FOXO3a in MCF-7 Breast Cancer Cells

(2014) Eveline A. I. F. Queiroz et al.   PLoS One

How mitochondrial dysfunction affects zebrafish development and cardiovascular function: anin vivomodel for testing mitochondria-targeted drugs

(2013) Brígida R Pinho et al.   BRITISH JOURNAL OF PHARMACOLOGY

A novel “Integrated Biomarker Response” calculation based on reference deviation concept

(2012) Wilfried Sanchez et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Zebrafish (Danio rerio) embryos as a model for testing proteratogens

(2011) Stefan Weigt et al.   TOXICOLOGY

Mitochondrial DNA mutations and human disease

(2009) Helen A.L. Tuppen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levels

(2008) Andrea Anedda et al.   JOURNAL OF ENDOCRINOLOGY

Metformin versus Insulin for the Treatment of Gestational Diabetes

(2008) Janet A. Rowan et al.   NEW ENGLAND JOURNAL OF MEDICINE