Ursolic acid alleviates tetrandrine-induced hepatotoxicity by competitively binding to the substrate-binding site of glutathione S-transferases

Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose

(2022) Jephte Y. Akakpo et al.   ARCHIVES OF TOXICOLOGY

Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis

(2022) Jianming Liu et al.   PHYTOMEDICINE

Atractylenolide-I covalently binds to CYP11B2, selectively inhibits aldosterone synthesis, and improves hyperaldosteronism

(2021) Wenjuan Liu et al.   Acta Pharmaceutica Sinica B

Research progress on the protective effects of licorice-derived 18β-glycyrrhetinic acid against liver injury

(2020) Shou-yan Wu et al.   ACTA PHARMACOLOGICA SINICA

Ursolic acid reduces hepatocellular apoptosis and alleviates alcohol-induced liver injury via irreversible inhibition of CASP3 in vivo

(2020) Xiao-yao Ma et al.   ACTA PHARMACOLOGICA SINICA

Synthesis, biological evaluation and toxicity of novel tetrandrine analogues

(2020) Ramona Schütz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thirteen bisbenzylisoquinoline alkaloids in five Chinese medicinal plants: Botany, traditional uses, phytochemistry, pharmacokinetic and toxicity studies

(2020) Han Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ursolic acid ameliorates CCl4-induced liver fibrosis through the NOXs/ROS pathway

(2018) Dakai Gan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Triterpenoids from fruits of Sorbus pohuashanensis inhibit acetaminophen-induced acute liver injury in mice

(2018) Yongxia Yin et al.   BIOMEDICINE & PHARMACOTHERAPY

Frequency and pathological characteristics of drug-induced liver injury in a tertiary medical center

(2017) Mark Ettel et al.   HUMAN PATHOLOGY

CYP3A5 mediates bioactivation and cytotoxicity of tetrandrine

(2015) Ye Tian et al.   ARCHIVES OF TOXICOLOGY

Utilization ofglutathione S-transferase Mu 1- andTheta 1-null mice as animal models for absorption, distribution, metabolism, excretion and toxicity studies

(2013) Shingo Arakawa   Expert Opinion on Drug Metabolism & Toxicology

Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen

(2013) Sanja Dragovic et al.   TOXICOLOGY LETTERS

Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences

(2012) Iva Boušová et al.   DRUG METABOLISM REVIEWS

Human cytosolic glutathione transferases: structure, function, and drug discovery

(2012) Baojian Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pulmonary Toxicity and Metabolic Activation of Tetrandrine in CD-1 Mice

(2011) Hua Jin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Methemoglobinemia Induced by 1,2-Dichloro-4-nitrobenzene in Mice with a Disrupted Glutathione S-Transferase Mu 1 Gene

(2010) S. Arakawa et al.   DRUG METABOLISM AND DISPOSITION

GlutathioneS-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury

(2008) M. Isabel Lucena et al.   HEPATOLOGY