Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis

Dual Agonist of Farnesoid X Receptor and G Protein‐coupled Receptor TGR5 Inhibits Hepatitis B Virus Infection in Vitro and in Vivo

(2021) Kiyoaki Ito et al.   HEPATOLOGY

Structure and Activity of Pentacyclic Triterpenes Codrugs. A Review

(2021) Justyna Żwawiak et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Oleanolic Acid Targets the Gut–Liver Axis to Alleviate Metabolic Disorders and Hepatic Steatosis

(2021) Chenyu Xue et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism

(2021) FanCheng Meng et al.   PHYTOMEDICINE

Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study

(2021) Vijay R. Varma et al.   PLOS MEDICINE

A UPLC-MS/MS-based metabolomics analysis of the pharmacological mechanisms of rabdosia serra against cholestasis

(2021) Kaihui Zhang et al.   PHYTOMEDICINE

The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology

(2020) Sanjay K. Nigam et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Tanshinone ⅡA may alleviate rifampin-induced cholestasis by regulating the expression and function of NTCP

(2020) Y Yang et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Anti-inflammatory, anti-oxidative stress and novel therapeutic targets for cholestatic liver injury

(2019) Yafei Zhang et al.   BioScience Trends

The gut microbial influence on cholestatic liver disease

(2019) Martin Kummen et al.   LIVER INTERNATIONAL

Tanshinone IIA prevents rifampicin‐induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2

(2019) Yujie Yang et al.   LIVER INTERNATIONAL

Diversification of host bile acids by members of the gut microbiota

(2019) Jenessa A. Winston et al.   Gut Microbes

Picroside II protects against cholestatic liver injury possibly through activation of farnesoid X receptor

(2019) Tingting Li et al.   PHYTOMEDICINE

Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations

(2018) Marica Cariello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Animal models of biliary injury and altered bile acid metabolism

(2018) Valeria Mariotti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oleanolic acid protects against pathogenesis of atherosclerosis, possibly via FXR-mediated angiotensin (Ang)-(1–7) upregulation

(2018) Yunyun Pan et al.   BIOMEDICINE & PHARMACOTHERAPY

Primary biliary cholangitis: Old and novel therapy

(2018) Annarosa Floreani et al.   European Journal of Internal Medicine

A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis

(2018) Kris V. Kowdley et al.   HEPATOLOGY

Manual acupuncture relieves bile acid-induced itch in mice: the role of microglia and TNF-α

(2018) Yu-Chen Lee et al.   International Journal of Medical Sciences

Yangonin protects against cholestasis and hepatotoxity via activation of farnesoid X receptor in vivo and in vitro

(2018) Xiaoguang Gao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

FXR modulators for enterohepatic and metabolic diseases

(2018) Hong Wang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses

(2018) Jie Liu et al.   LIVER INTERNATIONAL

Developments in bile salt based therapies: A critical overview

(2018) Joanne M. Donkers et al.   BIOCHEMICAL PHARMACOLOGY

The ascending pathophysiology of cholestatic liver disease

(2017) Peter L.M. Jansen et al.   HEPATOLOGY

Management of cholestatic disease in 2017

(2017) Elsemieke de Vries et al.   LIVER INTERNATIONAL

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

(2017) Wei Jia et al.   Nature Reviews Gastroenterology & Hepatology

Huangqi Decoction Alleviates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis by Reversing Disordered Bile Acid and Glutathione Homeostasis in Mice

(2017) Jia-Sheng Wu et al.   Frontiers in Pharmacology

Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism

(2015) Pan Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function

(2015) Ágnes Telbisz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2

(2015) Yuan-Fu Lu et al.   TOXICOLOGY LETTERS

Oleanolic acid

(2012) Jacob Pollier et al.   PHYTOCHEMISTRY

Dysregulation of glutathione synthesis during cholestasis in mice: Molecular mechanisms and therapeutic implications

(2009) Heping Yang et al.   HEPATOLOGY

Oleanolic acid is a selective farnesoid X receptor modulator

(2009) Wenming Liu et al.   PHYTOTHERAPY RESEARCH

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY