Atractylenolide-I covalently binds to CYP11B2, selectively inhibits aldosterone synthesis, and improves hyperaldosteronism

Cinnamaldehyde Enhances Antimelanoma Activity through Covalently Binding ENO1 and Exhibits a Promoting Effect with Dacarbazine

(2020) Weiyi Zhang et al.   Cancers

Testosterone concentrations and risk of cardiovascular events in androgen-deficient men with atherosclerotic cardiovascular disease

(2020) William E. Boden et al.   AMERICAN HEART JOURNAL

Substrate-induced modulation of protein-protein interactions within human mitochondrial cytochrome P450-dependent system

(2020) E.O. Yablokov et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Electrolyte transport in the renal collecting duct and its regulation by the renin–angiotensin–aldosterone system

(2019) Osamu Yamazaki et al.   CLINICAL SCIENCE

Mineralocorticoid receptor antagonists and kidney diseases: pathophysiological basis

(2019) Jonatan Barrera-Chimal et al.   KIDNEY INTERNATIONAL

Development of Highly Selective Pyrimidine-Based Aldosterone Synthase (CYP11B2) Inhibitors

(2019) Steven M. Sparks et al.   ACS Medicinal Chemistry Letters

Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation

(2019) Julia Schewe et al.   Nature Communications

Renin-Angiotensin-Aldosterone System Triple-A Analysis for the Screening of Primary Aldosteronism

(2019) Jacopo Burrello et al.   HYPERTENSION

Regulation of aldosterone production by ion channels: From basal secretion to primary aldosteronism

(2018) Tingting Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Discovery of Novel Pyrazole-Based Selective Aldosterone Synthase (CYP11B2) Inhibitors: A New Template to Coordinate the Heme-Iron Motif of CYP11B2

(2018) Ryo Sakakibara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis

(2018) Jianye Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Expanding Spectrum of Primary Aldosteronism: Implications for Diagnosis, Pathogenesis, and Treatment

(2018) Anand Vaidya et al.   ENDOCRINE REVIEWS

The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: A review

(2018) Bo Zhu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design

(2018) Simone Brixius-Anderko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPR—Based study of affinity of cytochrome P450s / redox partners interactions modulated by steroidal substrates

(2018) P.V. Ershov et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

UPLC-MS/MS of Atractylenolide I, Atractylenolide II, Atractylenolide III, and Atractyloside A in Rat Plasma after Oral Administration of Raw and Wheat Bran-Processed Atractylodis Rhizoma

(2018) Shizhao Xu et al.   MOLECULES

Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins

(2018) Yuan Zhang et al.   Acta Pharmaceutica Sinica B

Aldosterone and Mineralocorticoid Receptors—Physiology and Pathophysiology

(2017) John Funder   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ursolic Acid, a Natural Nutraceutical Agent, Targets Caspase3 and Alleviates Inflammation-Associated Downstream Signal Transduction

(2017) Xiaoyao Ma et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The potential of targeting CYP11B

(2016) Rita Bernhardt   EXPERT OPINION ON THERAPEUTIC TARGETS

Estrogen Signaling in the Adrenal Cortex

(2016) Brasilina Caroccia et al.   HYPERTENSION

Preclinical and Early Clinical Profile of a Highly Selective and Potent Oral Inhibitor of Aldosterone Synthase (CYP11B2)Novelty and Significance

(2016) Katrijn Bogman et al.   HYPERTENSION

Local Control of Aldosterone Production and Primary Aldosteronism

(2016) Enzo Lalli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hypertension: Renin-Angiotensin-Aldosterone System Alterations

(2015) L. te Riet et al.   CIRCULATION RESEARCH

The CYP11B subfamily

(2015) Lina Schiffer et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Narrative Review: The Emerging Clinical Implications of the Role of Aldosterone in the Metabolic Syndrome and Resistant Hypertension

(2013) James R. Sowers   ANNALS OF INTERNAL MEDICINE

Progress Towards Clinically Useful Aldosterone Synthase Inhibitors

(2013) Matthew Cerny   CURRENT TOPICS IN MEDICINAL CHEMISTRY

LCI699, a Potent 11β-hydroxylase Inhibitor, Normalizes Urinary Cortisol in Patients With Cushing's Disease: Results From a Multicenter, Proof-of-Concept Study

(2013) Xavier Bertagna et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Structural Insights into Aldosterone Synthase Substrate Specificity and Targeted Inhibition

(2013) Natallia Strushkevich et al.   MOLECULAR ENDOCRINOLOGY

Human aldosterone synthase: Recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level

(2012) Anna Hobler et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Hipertensión por hiperaldosteronismo: más lesión cardiaca, mayor riesgo cardiovascular

(2012) María Abad-Cardiel et al.   REVISTA ESPANOLA DE CARDIOLOGIA

Cytochrome P450: taming a wild type enzyme

(2011) Sang Taek Jung et al.   CURRENT OPINION IN BIOTECHNOLOGY

Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz

(2011) Hai Jiang et al.   MOLECULES

Recombinant human cytochrome P450 monooxygenases for drug metabolite synthesis

(2010) Kirsten Schroer et al.   BIOTECHNOLOGY AND BIOENGINEERING

Aldosterone: Role in Edematous Disorders, Hypertension, Chronic Renal Failure, and Metabolic Syndrome

(2010) R. W. Schrier et al.   Clinical Journal of the American Society of Nephrology

Aldosterone Synthase Inhibition With LCI699

(2010) Laurence Amar et al.   HYPERTENSION

Aldosterone: Role in the Cardiometabolic Syndrome and Resistant Hypertension

(2010) Adam Whaley-Connell et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors

(2009) Daniel LaSala et al.   ANALYTICAL BIOCHEMISTRY

Oxygen activation by cytochrome P450 monooxygenase

(2008) Djemel Hamdane et al.   PHOTOSYNTHESIS RESEARCH