Apelin-13 reduces lipopolysaccharide-induced neuroinflammation and cognitive impairment via promoting glucocorticoid receptor expression and nuclear translocation

Apelin-13 attenuates early brain injury through inhibiting inflammation and apoptosis in rats after experimental subarachnoid hemorrhage

(2022) Xiaoyan Shen et al.   MOLECULAR BIOLOGY REPORTS

An emerging role for microglia in stress‐effects on memory

(2021) Jeniffer Sanguino‐Gómez et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ketogenic therapy in neurodegenerative and psychiatric disorders: From mice to men

(2020) Ann-Katrin Kraeuter et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The Apelin/APJ System in Psychosis and Neuropathy

(2020) Shuang-Yu Lv et al.   Frontiers in Pharmacology

Glucocorticoid-induced enhancement of extinction—from animal models to clinical trials

(2019) Dominique de Quervain et al.   PSYCHOPHARMACOLOGY

A novel neurotherapeutic for multiple sclerosis, ischemic injury, methamphetamine addiction, and traumatic brain injury

(2019) Arthur A. Vandenbark et al.   Journal of Neuroinflammation

Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling

(2019) Jialin Duan et al.   Journal of Neuroinflammation

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer’s Disease Through Activation of BDNF-TrkB Signaling Pathway

(2019) Huaiqing Luo et al.   Frontiers in Pharmacology

Apelin-13 regulates LPS-induced N9 microglia polarization involving STAT3 signaling pathway

(2019) Shouhong Zhou et al.   NEUROPEPTIDES

Apelin attenuates depressive-like behavior and neuroinflammation in rats co-treated with chronic stress and lipopolysaccharide

(2019) Zi-xuan Zhang et al.   NEUROPEPTIDES

Apelin-13 enhances contextual fear extinction in rats

(2019) Fang-Ling Chen et al.   NEUROSCIENCE LETTERS

Phosphodiesterase-2 Inhibitor Bay 60-7550 Ameliorates Aβ-Induced Cognitive and Memory Impairment via Regulation of the HPA Axis

(2019) Lina Ruan et al.   Frontiers in Cellular Neuroscience

Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats

(2019) Weilin Xu et al.   Journal of Neuroinflammation

Apelin-13 ameliorates cognitive impairments in 6-hydroxydopamine-induced substantia nigra lesion in rats

(2018) Elham Haghparast et al.   NEUROPEPTIDES

Impaired resolution of DSS-induced colitis in mice lacking the glucocorticoid receptor in myeloid cells

(2018) Garrit K. Meers et al.   PLoS One

Therapeutic Mechanisms of Glucocorticoids

(2018) Jolien Vandewalle et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Apelin-13 Upregulates BDNF Against Chronic Stress-induced Depression-like Phenotypes by Ameliorating HPA Axis and Hippocampal Glucocorticoid Receptor Dysfunctions

(2018) Ting-Ting Dai et al.   NEUROSCIENCE

Protective role of Apelin-13 on amyloid β25–35-induced memory deficit; Involvement of autophagy and apoptosis process

(2018) Samaneh Aminyavari et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Apelin-13 ameliorates chronic water-immersion restraint stress-induced memory performance deficit through upregulation of BDNF in rats

(2018) Pei Shen et al.   NEUROSCIENCE LETTERS

Distinct modifications of hippocampal glucocorticoid receptor phosphorylation and FKBPs by lipopolysaccharide in depressive female and male rats

(2017) Zeljka Brkic et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Inflammatory Process in Alzheimer's and Parkinson's Diseases: Central Role of Cytokines

(2016) Qamre Alam et al.   CURRENT PHARMACEUTICAL DESIGN

Apelin-13 exerts antidepressant-like and recognition memory improving activities in stressed rats

(2016) E. Li et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Apelin-13 Impaires Acquisition but Not Consolidation or Expression of Contextual Fear in Rats

(2016) Li Han et al.   NEUROCHEMICAL RESEARCH

Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice

(2015) Dongdong Chen et al.   ASN Neuro

The contribution of hypothalamic neuroendocrine, neuroplastic and neuroinflammatory processes to lipopolysaccharide-induced depressive-like behaviour in female and male rats: Involvement of glucocorticoid receptor and C/EBP-β

(2015) Miroslav Adzic et al.   BEHAVIOURAL BRAIN RESEARCH

Interleukin-1β regulates the expression of glucocorticoid receptor isoforms in nasal polyps in vitro via p38 MAPK and JNK signal transduction pathways

(2015) Zhenlin Wang et al.   Journal of Inflammation-London

Neuroprotective effects of apelin-13 on experimental ischemic stroke through suppression of inflammation

(2015) Qing Xin et al.   PEPTIDES

The role of apelin-13 in novel object recognition memory

(2014) Ren-wen Han et al.   PEPTIDES

Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation

(2013) M Á Carrillo-de Sauvage et al.   CELL DEATH AND DIFFERENTIATION

A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer' disease

(2013) Pingping He et al.   HORMONES AND BEHAVIOR

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

(2013) Anne-Marie O'Carroll et al.   JOURNAL OF ENDOCRINOLOGY

Time–Course of Hypothalamic–Pituitary–Adrenal Axis Activity and Inflammation in Juvenile Rat Brain After Cranial Irradiation

(2012) Nataša Veličković et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation

(2012) Dillon Y Chen et al.   NATURE NEUROSCIENCE

Involvement of neurotransmitters in the action of apelin-13 on passive avoidance learning in mice

(2012) Gyula Telegdy et al.   PEPTIDES

Apelin Inhibits Insulin Secretion in Pancreatic β-Cells by Activation of PI3-Kinase-Phosphodiesterase 3B

(2009) Lin Guo et al.   ENDOCRINE RESEARCH

Enhancement of ligand-dependent down-regulation of glucocorticoid receptor by lipopolysaccharide

(2009) Noriyasu Hirasawa et al.   LIFE SCIENCES