Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer’s Disease Through Activation of BDNF-TrkB Signaling Pathway

1,3,7-Trihydroxyxanthone, derived from Polygalae Radix, a herbal medicine, stimulates the expression of neurotrophic factors in rat astrocyte primary cultures via cAMP- and ERK-dependent pathways

(2018) Honghong Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Apelin-13 ameliorates cognitive impairments in 6-hydroxydopamine-induced substantia nigra lesion in rats

(2018) Elham Haghparast et al.   NEUROPEPTIDES

The Hippocampus is a Critical Site Mediating Antidepressant-like Activity of Apelin-13 in Rats

(2018) Zhi-Yong Xiao et al.   NEUROSCIENCE

A transient insulin system dysfunction in newborn rat brain followed by neonatal intracerebroventricular administration of streptozotocin could be accompanied by a labile cognitive impairment

(2018) Zohreh Abbasi et al.   NEUROSCIENCE RESEARCH

Amelioration of Cognitive Deficit by Embelin in a Scopolamine-Induced Alzheimer’s Disease-Like Condition in a Rat Model

(2018) Saatheeyavaane Bhuvanendran et al.   Frontiers in Pharmacology

The Protective Effect of Betulinic Acid on Microvascular Responsivity and Protein Expression in Alzheimer Disease Induced by Cerebral Micro-Injection of Beta-Amyloid and Streptozotocin

(2018) Alireza Sarkaki et al.   MICROCIRCULATION

Apelin-13 Upregulates BDNF Against Chronic Stress-induced Depression-like Phenotypes by Ameliorating HPA Axis and Hippocampal Glucocorticoid Receptor Dysfunctions

(2018) Ting-Ting Dai et al.   NEUROSCIENCE

Inflammation and neurodegeneration: chronicity matters

(2018) Keenan A. Walker   Aging-US

Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer’s Disease

(2018) Aarti Mishra et al.   Frontiers in Aging Neuroscience

Protective role of Apelin-13 on amyloid β25–35-induced memory deficit; Involvement of autophagy and apoptosis process

(2018) Samaneh Aminyavari et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF function in a rodent model of neuroinflammation induced by central interleukin-1β administration

(2017) Yilong Dong et al.   EUROPEAN JOURNAL OF NUTRITION

Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease

(2017) M. Florencia Iulita et al.   NEUROBIOLOGY OF DISEASE

Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a

(2017) Ali M. El Halawany et al.   Scientific Reports

Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey

(2017) Eli Shobin et al.   GeroScience

Cognitive remission: a novel objective for the treatment of major depression?

(2016) Beatrice Bortolato et al.   BMC Medicine

Brain BDNF levels are dependent on cerebrovascular endothelium-derived nitric oxide

(2016) Hayat Banoujaafar et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Apelin-13 exerts antidepressant-like and recognition memory improving activities in stressed rats

(2016) E. Li et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Inflammation, Antiinflammatory Agents, and Alzheimer’s Disease: The Last 22 Years

(2016) Patrick L. McGeer et al.   JOURNAL OF ALZHEIMERS DISEASE

Apelin-13 Impaires Acquisition but Not Consolidation or Expression of Contextual Fear in Rats

(2016) Li Han et al.   NEUROCHEMICAL RESEARCH

Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice

(2016) Changrun Guo et al.   PHYTOMEDICINE

Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice

(2015) Dongdong Chen et al.   ASN Neuro

Neuroinflammation in Parkinson's disease: role in neurodegeneration and tissue repair

(2015) Sayinthen Vivekanantham et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Neuroprotective effects of apelin-13 on experimental ischemic stroke through suppression of inflammation

(2015) Qing Xin et al.   PEPTIDES

Assessment of C-phycocyanin effect on astrocytes-mediated neuroprotection against oxidative brain injury using 2D and 3D astrocyte tissue model

(2015) Seul Ki Min et al.   Scientific Reports

Hippocampal memory enhancing activity of pine needle extract against scopolamine-induced amnesia in a mouse model

(2015) Jin-Seok Lee et al.   Scientific Reports

Transmitter mediation of the anxiolytic action of apelin-13 in male mice

(2014) Gyula Telegdy et al.   BEHAVIOURAL BRAIN RESEARCH

Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses

(2014) Shenghui Chu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Brain-Derived Neurotrophic Factor in Alzheimer’s Disease: Risk, Mechanisms, and Therapy

(2014) Jing-Hui Song et al.   MOLECULAR NEUROBIOLOGY

The role of apelin-13 in novel object recognition memory

(2014) Ren-wen Han et al.   PEPTIDES

Dynamic changes of peritoneal macrophages and subpopulations during ulcerative colitis to metastasis of colorectal carcinoma in a mouse model

(2013) Wei Wang et al.   INFLAMMATION RESEARCH

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

(2013) Anne-Marie O'Carroll et al.   JOURNAL OF ENDOCRINOLOGY

Green tea (−)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia

(2012) Regina Biasibetti et al.   BEHAVIOURAL BRAIN RESEARCH

Review: Systemic inflammation and Alzheimer's disease

(2012) C. Holmes   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neuroprotection of apelin and its signaling pathway

(2012) Baohua Cheng et al.   PEPTIDES

Brain-Derived Neurotrophic Factor: A Dynamic Gatekeeper of Neural Plasticity

(2012) Kiriana Cowansage et al.   Current Molecular Pharmacology

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

(2011) M. Kitazawa et al.   JOURNAL OF IMMUNOLOGY

Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease: a long-term follow up study

(2011) Melita Salkovic-Petrisic et al.   JOURNAL OF NEURAL TRANSMISSION

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

(2010) Jian-Quan Shi et al.   BRAIN RESEARCH

Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures

(2010) Roberta Bovolenta et al.   Journal of Neuroinflammation

Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats

(2010) Y. Jiang et al.   NEUROSCIENCE

Decreased levels of PSD95 and two associated proteins and increased levels of BCl2and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Aβ, and neurodegeneration in a prodromal stage of Alzheimer's disease

(2009) Rukhsana Sultana et al.   JOURNAL OF NEUROSCIENCE RESEARCH

New insights into brain BDNF function in normal aging and Alzheimer disease

(2008) Lucia Tapia-Arancibia et al.   BRAIN RESEARCH REVIEWS

Neurotrophins differentially enhance acetylcholine release, acetylcholine content and choline acetyltransferase activity in basal forebrain neurons

(2003) Daniel S. Auld et al.   JOURNAL OF NEUROCHEMISTRY